Composite image to demonstrate a pituitary mass typical of cats with acromegaly.

<p>Transverse (left) and saggital (middle) CT images showing a contrast enhancing pituitary mass (>4mm height) in a cat with acromegaly. Without treatment, the cat was euthanised some months later and post-mortem examination demonstrated the large pituitary mass (right). Histopathology was consistent with an acidophil adenoma.</p

Population characteristics of cats whose myocardial tissue was analysed in the histopathologic study.

<p><i>HCM</i>, <i>hypertrophic cardiomyopathy; HW</i>, <i>heart weight; BW</i>, <i>body weight; RVFW</i>, <i>right ventricular free wall thickness; IVS</i>, <i>interventricular septal thickness; LVFW</i>, <i>left ventricular wall thickness</i>.</p

Population characteristics of cats enrolled in the echocardiographic study.

<p>Normally distributed data are represented mean (±standard deviation) and compared using a one-way ANOVA. Non-normally distributed data are represented median (range) and compared using a Kruskal-Wallis test. Categorical variables are represented as percentages and compared using a Chi squared test.</p

Box and whisker plot to illustrate the difference in maximum left ventricular (LV) wall thickness between the three groups of cats at enrolment.

<p>DM, diabetes mellitus; HS, hypersomatotropism.</p

Echocardiographic and plasma IGF-1 measurements before and after treatment of acromegaly.

<p>Echocardiographic and plasma IGF-1 measurements before and after treatment of acromegaly.</p

Echocardiographic measurements of all cats enrolled in the study.

<p>Normally distributed data are represented mean (±standard deviation) and compared using a one-way ANOVA. Non-normally distributed data are represented median (range) and compared using a Kruskal-Wallis test. Categorical variables are represented as percentages and compared using a Chi squared test.</p

Box plot to show the proportion of cats affected by myocardial inflammatory cell infiltrate in each group.

<p>Box plot to show the proportion of cats affected by myocardial inflammatory cell infiltrate in each group.</p

Box and whisker plots to illustrate the difference in left atrial size between groups at enrolment.

<p>DM, diabetes mellitus; HS, hypersomatotropism.</p

Paws of an overtly acromegalic cat.

<p>This figure shows a cat with confirmed acromegaly demonstrating so-called clubbed paws; enlargement of the paws due to acromegaly.</p

Example of prognathia inferior.

<p>This figure shows a cat with confirmed acromegaly demonstrating prognathia inferior (a), including a sagittal CT view of the cat’s head illustrating this conformational change further (b).</p