104 research outputs found
Evidence for a modulation of neutral trehalase activity by Ca2+ and cAMP signaling pathways in Saccharomyces cerevisiae
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Multidrug efflux pumps:structure, function and regulation
- Author
- A Ababou
- A Crow
- A Gayen
- A Kodan
- A Lee
- A Parker
- A Yamaguchi
- AA Neyfakh
- AC Kuk
- AD Kinana
- AJ Sachla
- AM Bailey
- AM Buckley
- Arthur Neuberger
- AV Vargiu
- AW Fitzpatrick
- B Verhalen
- BC Young
- BD Schindler
- Ben F. Luisi
- C Martens
- C Oswald
- C Perez
- C-C Su
- C-Y Kao
- CP Zschiedrich
- D Dar
- D Dar
- D Du
- D Golparian
- D Jiang
- D Khare
- D Lalaouna
- D Machado
- DC Bay
- DE Kunkle
- DG Thanassi
- Dijun Du
- E Maisonneuve
- E Vidyaprakash
- EA Morrison
- EA Ohneck
- EC Hobbs
- EH Lee
- EM Quistgaard
- G Fritz
- G Sennhauser
- G Storz
- G Wisedchaisri
- GE Richmond
- H Chen
- H Nikaido
- H Piepenbreier
- H Sakhtah
- H Singh
- H Sjuts
- H Venter
- H Yamanaka
- H Yao
- H-J Cha
- H-S Kim
- Hendrik W. van Veen
- HG Choudhury
- HG Stickland
- HR Kaback
- HS Fraimow
- HT Lin
- I Gushchin
- I Lytvynenko
- I Marchand
- I Ranaweera
- J Dreier
- J Heng
- J Lee
- J Nowak
- J Sun
- J Yamada
- J-R Sun
- J-S Woo
- JD Moore
- JJ Mousa
- JL Doran
- JM Blair
- JM Blair
- JO Pacheco
- JR Bolla
- K Andries
- K Bountra
- K Koteva
- K Nishino
- K Nishino
- K Nishino
- K Nishino
- K Poole
- KA Hassan
- KA Hassan
- KE Hagman
- Klaas M. Pos
- KM Pos
- KN Adams
- KP Locher
- L Federici
- L Rodrigues
- L-W Hung
- LA Jackson
- Laura J. V. Piddock
- LD Elbourne
- LH Hansen
- LM Bogomolnaya
- LM Hürlimann
- M Alcalde-Rico
- M Li
- M Lu
- M Lu
- M Masureel
- M Radchenko
- M Radchenko
- M Zampieri
- M Zwama
- M-F Lin
- MA Schumacher
- MA Seeger
- MA Seeger
- MC Swick
- MG Lamarche
- MJ Everett
- MS Jin
- MS Wilke
- N Fluman
- N Fluman
- N Fluman
- N Kobayashi
- N Kumar
- N Li
- N Tal
- NB Woodall
- NL Podnecky
- NQ Balaban
- P Casino
- P Dersch
- P Sharma
- P Viale
- PR Steed
- R Dastvan
- R González-Pasayo
- R Nakashima
- R Nakashima
- RJ Dawson
- RJ Nichols
- RM Ryan
- S Brill
- S Majumdar De
- S Minagawa
- S Mishra
- S Murakami
- S Murakami
- S Radestock
- S Yang
- SJ Fleishman
- SK Aoki
- T Bergmiller
- T Eicher
- T Eicher
- T Horiyama
- T Tsukazaki
- T Yoshida
- T-Y Chang
- TA Schaedler
- U Okada
- VB Srinivasan
- VK Ramaswamy
- VM Korkhov
- W Mi
- X Gong
- X He
- X Wang-Kan
- X-Z Li
- X-Z Li
- Xuan Wang-Kan
- Y Göpel
- Y Jin
- Y Norimatsu
- Y Pu
- Y Tanaka
- Y Yin
- Y Zhao
- Y-J Chen
- Z Wang
- ZC Ruhe
- ZL Johnson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 12/07/2018
- Field of study
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities
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Search for Higgs boson decays to a Z boson and a photon in proton-proton collisions at s = 13 TeV
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- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abercrombie D
- Abreu A
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- Agapitos A
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- Ahmad A
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- Aimè C
- Akchurin N
- Akgun B
- Akpinar A
- Albergo S
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- Albrow M
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- Aldaya Martin M
- Aldá Júnior WL
- Aleksandrov A
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- Zalewski P
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- Zghiche A
- Zhang F
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- Zhao J
- Zhizhin I
- Zhokin A
- Zhu RY
- Ziemons T
- Zipper N
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zotz A
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- Zou R
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 01/08/2022
- Field of study
A preprint version of the article is available at arXiv:2204.12945v2 [hep-ex], https://arxiv.org/abs/2204.12945v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-19-014 (CMS Public Pages). Report number: CMS-HIG-19-014, CERN-EP-2022-019.Results are presented from a search for the Higgs boson decay H → Zγ, where Z → ℓ+ℓ− with ℓ = e or μ. The search is performed using a sample of proton-proton (pp) collision data at a center-of-mass energy of 13 TeV, recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of 138 fb^{−1}. Events are assigned to mutually exclusive categories, which exploit differences in both event topology and kinematics of distinct Higgs production mechanisms to enhance signal sensitivity. The signal strength μ, defined as the product of the cross section and the branching fraction [σ(pp → H)B(H → Zγ)] relative to the standard model prediction, is extracted from a simultaneous fit to the ℓ+ℓ−γ invariant mass distributions in all categories and is found to be μ = 2.4 ± 0.9 for a Higgs boson mass of 125.38 GeV. The statistical significance of the observed excess of events is 2.7 standard deviations. This measurement corresponds to σ(pp → H)B(H → Zγ) = 0.21 ± 0.08 pb. The observed (expected) upper limit at 95% confidence level on μ is 4.1 (1.8). The ratio of branching fractions B(H → Zγ)/B(H → γγ) is measured to be 1.5 +0.7−0.6, which agrees with the standard model prediction of 0.69 ± 0.04 at the 1.5 standard deviation level.SCOAP3
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- Zuo X
- Zuolo D
- Zygala L
- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 09/10/2022
- Field of study
A preprint version of the article is available at arXiv:2206.09466v2 [hep-ex], https://arxiv.org/abs/2206.09466v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at httpS://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-20-013 (CMS Public Pages). Report number: CMS-HIG-20-013, CERN-EP-2022-120.Production cross sections of the standard model Higgs boson decaying to a pair of W bosons are measured in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis targets Higgs bosons produced via gluon fusion, vector boson fusion, and in association with a W or Z boson. Candidate events are required to have at least two charged leptons and moderate missing transverse momentum, targeting events with at least one leptonically decaying W boson originating from the Higgs boson. Results are presented in the form of inclusive and differential cross sections in the simplified template cross section framework, as well as couplings of the Higgs boson to vector bosons and fermions. The data set collected by the CMS detector during 2016-2018 is used, corresponding to an integrated luminosity of 138 fb^−1. The signal strength modifier μ, defined as the ratio of the observed production rate in a given decay channel to the standard model expectation, is measured to be μ = 0.95 +0.10−0.09. All results are found to be compatible with the standard model within the uncertainties.SCOAP3
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- Zuolo D
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- Álvarez Fernández A
- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 15/02/2024
- Field of study
A preprint version of the article is available at arXiv:2311.11370v2 [nucl-ex], https://arxiv.org/abs/2311.11370 .
Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/HIN-21-010 (CMS Public Pages).The hydrodynamic flow-like behavior of charged hadrons in high-energy lead-lead collisions is studied through multiparticle correlations. The elliptic anisotropy values based on different orders of multiparticle cumulants, v2{2k}, are measured up to the tenth order (k = 5) as functions of the collision centrality at a nucleon-nucleon center-of-mass energy of √sNN = 5.02 TeV. The data were recorded by the CMS experiment at the LHC and correspond to an integrated luminosity of 0.607 nb−1. A hierarchy is observed between the coefficients, with v2{2}>v2{4}≳v2{6}≳v2{8}≳v2{10}. Based on these results, centrality-dependent moments for the fluctuation-driven event-by-event v2 distribution are determined, including the skewness, kurtosis and, for the first time, superskewness. Assuming a hydrodynamic expansion of the produced medium, these moments directly probe the initial-state geometry in high-energy nucleus-nucleus collisions.SCOAP3
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 13/12/2023
- Field of study
A preprint version of the article is available at arXiv:2305.07998v2 [hep-ex], https://arxiv.org/abs/2305.07998v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-20-012 (CMS Public Pages). Report number: CMS-EXO-20-012, CERN-EP-2023-064.A search for resonances in events with the γ+jet final state has been performed using proton-proton collision data collected at √s = 13 TeV by the CMS experiment at the LHC. The total data analyzed correspond to an integrated luminosity of 138 fb−1. Models of excited quarks and quantum black holes are considered. Using a wide-jet reconstruction for the candidate jet, the γ+jet invariant mass spectrum measured in data is examined for the presence of resonances over the standard model continuum background. The background is estimated by fitting the mass distribution with a functional form. The data exhibit no statistically significant deviations from the expected standard model background. Exclusion limits at 95% confidence level on the resonance mass and other parameters are set. Excited light-flavor quarks (excited bottom quarks) are excluded up to a mass of 6.0 (3.8) TeV. Quantum black hole production is excluded for masses up to 7.5 (5.2) TeV in the Arkani-Hamed-Dimopoulos-Dvali (Randall-Sundrum) model. These lower mass bounds are the most stringent to date among those obtained in the γ+jet final state.SCOAP3
Recommended from our members
Search for direct production of GeV-scale resonances decaying to a pair of muons in proton-proton collisions at s = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
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- Zoi I
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- Zorbilmez C
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- Zuolo D
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 30/11/2023
- Field of study
A preprint version of the article is available at arXiv:2309.16003v2 [hep-ex], https://arxiv.org/abs/2309.16003v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables, including additional supplementary figures, can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-21-005 (CMS Public Pages). Report number: CMS-EXO-21-005, CERN-EP-2023-165.A search for direct production of low-mass dimuon resonances is performed using s√ = 13 TeV proton-proton collision data collected by the CMS experiment during the 2017-2018 operation of the CERN LHC with an integrated luminosity of 96.6 fb−1. The search exploits a dedicated high-rate trigger stream that records events with two muons with transverse momenta as low as 3 GeV but does not include the full event information. The search is performed by looking for narrow peaks in the dimuon mass spectrum in the ranges of 1.1-2.6 GeV and 4.2-7.9 GeV. No significant excess of events above the expectation from the standard model background is observed. Model-independent limits on production rates of dimuon resonances within the experimental fiducial acceptance are set. Competitive or world's best limits are set at 90% confidence level for a minimal dark photon model and for a scenario with two Higgs doublets and an extra complex scalar singlet (2HDM+S). Values of the squared kinetic mixing coefficient ε2 in the dark photon model above 10−6 are excluded over most of the mass range of the search. In the 2HDM+S, values of the mixing angle sin(θH) above 0.08 are excluded over most of the mass range of the search with a fixed ratio of the Higgs doublets vacuum expectation tanβ = 0.5.SCOAP3
Recommended from our members
Azimuthal anisotropy of dijet events in PbPb collisions at √sNN = 5.02TeV
- Author
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- Yusuff I
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- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
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- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Álvarez Fernández A
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 17/07/2023
- Field of study
A preprint version of the article is available at arXiv - https://arxiv.org/abs/2210.08325The path-length dependent parton energy loss within the dense partonic
medium created in lead-lead collisions at a nucleon-nucleon center-of-mass energy of
√sNN = 5.02TeV is studied by determining the azimuthal anisotropies for dijets with
high transverse momentum. The data were collected by the CMS experiment in 2018
and correspond to an integrated luminosity of 1.69nb−1. For events containing back-to
back jets, correlations in relative azimuthal angle and pseudorapidity (η) between jets and
hadrons, and between two hadrons, are constructed. The anisotropies are expressed as the
Fourier expansion coefficients vn, n = 2–4 of these azimuthal distributions. The dijet vn
values are extracted from long-range (1.5 < |∆η| < 2.5) components of these correlations,
which suppresses the background contributions from jet fragmentation processes. Positive
dijet v2 values are observed which increase from central to more peripheral events, while
the v3 and v4 values are consistent with zero within experimental uncertainties.SCOAP
Recommended from our members
Search for W′ bosons decaying to a top and a bottom quark in leptonic final states in proton-proton collisions at s = 13 TeV
- Author
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- Aarup Petersen H
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- Publication venue
- Springer Nature
- Publication date
- 05/04/2024
- Field of study
A preprint version of the article is available at arXiv:2310.19893v1 [hep-ex], https://arxiv.org/abs/2310.19893v1 . Comments: Submitted to the Journal of High Energy Physics. All figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/B2G-20-012 (CMS Public Pages). Report number: CMS-B2G-20-012, CERN-EP-2023-213.A search for W' bosons decaying to a top and a bottom quark in final states including an electron or a muon is performed with the CMS detector at the LHC. The analyzed data correspond to an integrated luminosity of 138 fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 Tev. Good agreement with the standard model expectation is observed and no evidence for the existence of the W' boson is found over the mass range examined. The largest observed deviation from the standard model expectation is found for a W' boson mass (mW′) hypothesis of 3.8 TeV with a relative decay width of 1%, with a local (global) significance of 2.6 (2.0) standard deviations. Upper limits on the production cross sections of W' bosons decaying to a top and a bottom quark are set. Left- and right-handed W' bosons with mW′ below 3.9 and 4.3 TeV, respectively, are excluded at the 95% confidence level, under the assumption that the new particle has a narrow decay width. Limits are also set for relative decay widths up to 30%. These are the most stringent limits to date on this W' boson decay channel.SCOAP3
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Search for new Higgs bosons via same-sign top quark pair production in association with a jet in proton-proton collisions at √s = 13 TeV
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- Aarup Petersen H
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- Wittich P
- Wittig F
- Wolf M
- Wolf R
- Wong WY
- Wood D
- Wright D
- Wu HY
- Wuchterl S
- Wulansatiti M
- Wulff JW
- Wulz C-E
- Wunsch S
- Wyslouch B
- Würthwein F
- Xiang Y
- Xiao J
- Xiao M
- Xie S
- Xie W
- Yagil A
- Yalvac M
- Yan F
- Yan X
- Yanes E
- Yang H
- Yang S
- Yang TJ
- Yang UK
- Yang Y
- Yang YC
- Yao Y
- Yarar H
- Yates BR
- Yazgan E
- Ye Z
- Yi K
- Yi R
- Yigitbasi E
- Yockey H
- Yohay R
- Yoo HD
- Yoo J
- Yoo J
- Yoon I
- You Z
- Yu D
- Yu I
- Yu SS
- Yuan L
- Yuan S
- Yuldashev BS
- Yusuff I
- Zabi A
- Zabolotny W
- Zacharopoulou A
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zaza A
- Zecchinelli AG
- Zehetner P
- Zeinali M
- Zejdl P
- Zeuner WD
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang W
- Zhang Y
- Zhang Y
- Zhizhin I
- Zhokin A
- Zhou C
- Zhu RY
- Ziemons T
- Zilizi G
- Zimermmane Castro Santos A
- Zipper N
- Zisopoulos I
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zotz A
- Zou R
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Publication venue
- Elsevier
- Publication date
- 02/02/2024
- Field of study
Data availability:
Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in “CMS data preservation, re-use and open access policy” available online at: https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2 .A preprint of this article is available online at arXiv:2311.03261v2 [hep-ex] https://arxiv.org/abs/2311.03261v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/TOP-22-010 (CMS Public Pages)A search is presented for new Higgs bosons in proton-proton (pp) collision events in which a same-sign top quark pair is produced in association with a jet, via the pp → tH/A → tt¯c and pp → tH/A → tt¯u processes. Here, H and A represent the extra scalar and pseudoscalar boson, respectively, of the second Higgs doublet in the generalized two-Higgs-doublet model (g2HDM). The search is based on pp collision data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fb−1. Final states with a same-sign lepton pair in association with jets and missing transverse momentum are considered. New Higgs bosons in the 200-1000 GeV mass range and new Yukawa couplings between 0.1 and 1.0 are targeted in the search, for scenarios in which either H or A appear alone, or in which they coexist and interfere. No significant excess above the standard model prediction is observed. Exclusion limits are derived in the context of the g2HDM.SCOAP3
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