1,178 research outputs found

    Bariatric surgery in patients with type 2 diabetes

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    Estimates of Micro-, Nano-, and Picoplankton Contributions to Particle Export in the Northeast Pacific

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    The contributions of micro-, nano-, and picoplankton to particle export were estimated from measurements of size-fractionated particulate 234Th, organic carbon, and phytoplankton indicator pigments obtained during five cruises between 2010 and 2012 along Line P in the subarctic northeast Pacific Ocean. Sinking fluxes of particulate organic carbon (POC) and indicator pigments were calculated from 234Th–238U disequilibria and, during two cruises, measured by sediment trap at Ocean Station Papa. POC fluxes at 100 m ranged from 0.65–7.95 mmol m−2 d−1, similar in magnitude to previous results at Line P. Microplankton pigments dominate indicator pigment fluxes (averaging 69 ± 19% of total pigment flux), while nanoplankton pigments comprised the majority of pigment standing stocks (averaging 64 ± 23% of total pigment standing stock). Indicator pigment loss rates (the ratio of pigment export flux to pigment standing stock) point to preferential export of larger microplankton relative to smaller nano- and picoplankton. However, indicator pigments do not quantitatively trace particle export resulting from zooplankton grazing, which may be an important pathway for the export of small phytoplankton. These results have important implications for understanding the magnitude and mechanisms controlling the biological pump at Line P in particular, and more generally in oligotrophic gyres and high-nutrient, low-chlorophyll regions where small phytoplankton represent a major component of the autotrophic community

    An experimental study of the dual-fuel performance of a small compression ignition diesel engine operating with three gaseous fuels

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    A dual-fuel engine is a compression ignition (CI) engine where the primary gaseous fuel source is premixed with air as it enters the combustion chamber. This homogenous mixture is ignited by a small quantity of diesel, the ‘pilot’, that is injected towards the end of the compression stroke. In the present study, a direct-injection CI engine, was fuelled with three different gaseous fuels: methane, propane, and butane. The engine performance at various gaseous concentrations was recorded at 1500 r/min and quarter, half, and three-quarters relative to full a load of 18.7 kW. In order to investigate the combustion performance, a novel three-zone heat release rate analysis was applied to the data. The resulting heat release rate data are used to aid understanding of the performance characteristics of the engine in dual-fuel mode. Data are presented for the heat release rates, effects of engine load and speed, brake specific energy consumption of the engine, and combustion phasing of the three different primary gaseous fuels. Methane permitted the maximum energy substitution, relative to diesel, and yielded the most significant reductions in CO2. However, propane also had significant reductions in CO2 but had an increased diffusional combustion stage which may lend itself to the modern high-speed direct-injection engine

    Socioeconomic risk, parenting during the preschool years and child health age 6 years

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    Parent–child relationships and parenting processes are emerging as potential life course determinants of health. Parenting is socially patterned and could be one of the factors responsible for the negative effects of social inequalities on health, both in childhood and adulthood. This study tests the hypothesis that some of the effect of socioeconomic risk on health in mid childhood is transmitted via early parenting. Methods: Prospective cohort study in 10 USA communities involving 1041 mother/ child pairs, selected at birth at random with conditional sampling. Exposures: income, maternal education, maternal age, lone parenthood, ethnic status and objective assessments of mother child interaction in the first 4 years of life covering warmth, negativity and positive control. Outcomes: mother’s report of child’s health in general at 6 years. Modelling: multiple regression analyses with statistical testing of mediational processes. Results: All five indicators of socioeconomic status (SES) were correlated with all three measures of parenting, such that low SES was associated with poor parenting. Among the measures of parenting maternal warmth was independently predictive of future health, and among the socioeconomic variables maternal education, partner presence and ‘other ethnic group’ proved predictive. Measures of parenting significantly mediated the impact of measures of SES on child health. Conclusions: Parenting mediates some, but not all of the detectable effects of socioeconomic risk on health in childhood. As part of a package of measures that address other determinants, interventions to support parenting are likely to make a useful contribution to reducing childhood inequalities in health

    Rotating perfect fluid sources of the NUT metric

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    Locally rotationally symmetric perfect fluid solutions of Einstein's gravitational equations are matched along the hypersurface of vanishing pressure with the NUT metric. These rigidly rotating fluids are interpreted as sources for the vacuum exterior which consists only of a stationary region of the Taub-NUT space-time. The solution of the matching conditions leaves generally three parameters in the global solution. Examples of perfect fluid sources are discussed.Comment: 8 pages, late

    Multiobjective, preference-based search in acyclic OR-graphs

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    We consider the problem of determining a most preferred path from a start node to a goal node set in an acyclic OR-graph, given a multiattribute preference function, a multiobjective reward structure, and heuristic information about this reward structure. We present an algorithm which is shown to terminate with a most preferred path, given an admissible heuristic set. The algorithm illustrates how Artificial Intelligence techniques can be productively employed to solve multiobjective problems.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30207/1/0000597.pd

    Principal null directions of perturbed black holes

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    The properties of principal null directions of a perturbed black hole are investigated. It shown that principal null directions are directly observable quantities characterizing the space-time. A definition of a perturbed space-time, generalizing that given by Stewart and Walker is proposed. This more general framework allows one to include descriptions of a given space-time other than by a pair (M,g)(M,g) where MM is a four-dimensional differential manifold and gg a Lorentz metric. Examples of alternative characterizations are the curvature representation of Karlhede and others, the Newman-Penrose representation or observable quantities involving principal null directions. The conditions are studied under which the various alternative choices of observables provide equivalent descriptions of the space-time.Comment: To appear in Class. Quantum Gra

    Ellipsoidal shapes in general relativity: general definitions and an application

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    A generalization of the notion of ellipsoids to curved Riemannian spaces is given and the possibility to use it in describing the shapes of rotating bodies in general relativity is examined. As an illustrative example, stationary, axisymmetric perfect-fluid spacetimes with a so-called confocal inside ellipsoidal symmetry are investigated in detail under the assumption that the 4-velocity of the fluid is parallel to a time-like Killing vector field. A class of perfect-fluid metrics representing interior NUT-spacetimes is obtained along with a vacuum solution with a non-zero cosmological constant.Comment: Latex, 22 pages, Revised version accepted in Class. Quantum. Grav., references adde

    General Relativistic 1+3 Orthonormal Frame Approach Revisited

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    The equations of the 1+3 orthonormal frame approach are explicitly presented and discussed. Natural choices of local coordinates are mentioned. A dimensionless formulation is subsequently given. It is demonstrated how one can obtain a number of interesting problems by specializing the general equations. In particular, equation systems for ``silent'' dust cosmological models also containing magnetic Maxwell fields, locally rotationally symmetric spacetime geometries and spatially homogeneous cosmological models are presented. We show that while the 3-Cotton--York tensor is zero for Szekeres dust models, it is nonzero for a generic representative within the ``silent'' class.Comment: 41 pages, uufiles encoded postscript file, submitted to Phys. Rev.

    Implications of the PEGASUS-TIMI 54 Trial for US Clinical Practice

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    Objectives This study aims to determine the proportion of real-world patients with myocardial infarction (MI) who would have been eligible for the PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54) trial, to characterise their current use of P2Y12 inhibitors and to explore the estimated costs and ischaemic event consequences of increasing P2Y12 inhibitor use among these patients. Methods In the US national ACTION Registry–GWTG (Acute Coronary Treatment and Intervention Outcomes Network Registry–Get With The Guidelines), we identified 273 328 patients with MI and determined the proportion that would have met the eligibility criteria for the PEGASUS trial. We described longitudinal P2Y12 inhibitor use among patients eligible for PEGASUS and estimated the cost and ischaemic consequences of increasing P2Y12 use among eligible patients. Results A total of 112 222 (41.1%) patients with MI in ACTION Registry–GWTG met eligibility for the PEGASUS trial. Among 83 871 eligible patients with pharmacy claims data, 23 042 (27.5%) were on a P2Y12 inhibitor at 1 year, 9661 (11.5%) at 2 years and 5246 (6.3%) at 3 years, with the majority (79.2%) of these patients on clopidogrel. The use of ticagrelor in eligible patients not yet on a P2Y12 inhibitor at 1 year post-MI would cost an estimated US885000perMI,strokeorcardiovasculardeathavertedovera3yeartimehorizon,whiletheuseofclopidogrelwouldcostanestimatedUS885 000 per MI, stroke or cardiovascular death averted over a 3-year time horizon, while the use of clopidogrel would cost an estimated US19 800 per ischaemic event averted. Conclusion In contemporary clinical practice, a minority of patients are on a P2Y12 inhibitor beyond 1-year post-MI. Applying PEGASUS trial findings to clinical practice would result in a large increase in P2Y12 inhibitor use, with a cost per ischaemic event averted that is strongly influenced by the choice of therapy
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