Model fitted log₂ control chip intensity vs. log₂ IVM (1 µg/ml, 1.1 µM) chip intensity.

<p>The scatter plot represents the entire 22625 probesets represented on the Affymetrix chips. The upper and lower dashed lines represent up-regulation greater than 2-fold and down-regulation greater than 2-fold respectively. The data points marked A-H represent the top 10 up-regulated genes in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031367#pone-0031367-t002" target="_blank">Table 2</a>.</p

Top 10 up-regulated probesets based on fold change following 4 hr exposure of DA1316 to 100 ng/ml (0.1 µM) IVM.

<p>Top 10 up-regulated probesets based on fold change following 4 hr exposure of DA1316 to 100 ng/ml (0.1 µM) IVM.</p

Pharyngeal pumping rate following 4 hr exposure of DA1316 and N2 to 0–1000 ng/ml (1.14 µM) IVM.

<p>Whilst strain DA1316 is more resistant to IVM induced pharyngeal paralysis, at concentrations greater than 100 ng/ml (0.1 µM) the pharyngeal pumping rate is significantly reduced. The pharyngeal pumping rates of five worms were counted at each concentration of IVM and the error bars represent the standard deviation.</p

Differential expression of 18 fasting response genes*, in the 1 µg/ml (1.1 µM) IVM exposure microarray experiment.

<p>In general genes that were shown to be induced by fasting were also induced following exposure to IVM and fasting repressed genes were also repressed by IVM exposure. *Taken from van Gilst <i>et al.</i> 2005 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031367#pone.0031367-VanGilst1" target="_blank">[24]</a>.</p

GFP expression patterns of IVM responsive genes.

<p><i>mtl-1</i>, <i>scl-2</i>, <i>cyp-37B1</i> and <i>ilys-3</i> are expressed in the intestine and C23G10.11 is expressed in the hypodermal cells. These are both proposed sites of fat storage.</p

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