MOESM1 of Risk of heart failure hospitalization among users of dipeptidyl peptidase-4 inhibitors compared to glucagon-like peptide-1 receptor agonists

Additional file 1: Figure S1. Flow diagram of the study population

MOESM1 of Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants

Additional file 1. Two sets of supplementary tables are included for Figs. 2, 4, 5, 6, 8, 9, and 10. One set of tables (A) shows the antiviral activities of the INSTIs against INSTI-resistant mutants and the other set of tables (B) shows the statistical significance (p values) when comparing antiviral activities against INSTI-resistant mutants among the INSTIs

MOESM1 of Establishing energy requirements for body weight maintenance: validation of an intake-balance method

Additional file 1. Additional information

MOESM2 of Drug resistant integrase mutants cause aberrant HIV integrations

Additional file 2. Structure of the aberrant proviruses isolated from cells treated with suboptimal concentrations of EVG (Table S1); from cells infected with viruses harboring RAL resistant mutations and treated with suboptimal doses of RAL (Tables S2–S4). The inhibitory concentrations of EVG or RAL used to treat the cells are indicated. The aberrations in the viral LTRs and in the integrated host chromosome(s) are indicated. U-LTR: the LTR adjacent to the primer binding site; D-LTR: the LTR adjacent to the polypurine tract

Distinguishing PCA from BPH Based on Nanodevice Binding to Thioredoxin Interacting Proteins.

<p>Surgically resected tissue specimens were obtained from 35 patients. Serial sections of the tissue specimens (5 µm thick) were incubated with 20 nM of the nanodevice in PBS and 1% BSA. Fluorescence binding was observed and a numerical grading system was given as the level of nanodevice fluorescence in the stroma by two independent investigators (the author EMS and GB from acknowledgements). <b>0-</b> No visible signal, <b>1-</b> weakly visible signal, <b>2-</b> a moderately intense visible signal and <b>3-</b> a bright and intense signal within the reactive stroma. The binding level for PCA-associated stroma was significantly greater than that of BPH (p = 0.0127) based on the t-test.</p

Additional file 1: Figure S1. of A novel clinical approach to evaluating changes in fat oxidation in healthy, overnight-fasted subjects

Pre- and Post-Intralipid Respiratory Quotient Values. A. Average RQ values measured during the Pre-Intralipid/Baseline phase of the test visit and post-Intralipid RQ values. #Denotes significant difference in LG group Pre-Intralipid/Baseline measure with respect to the LS group. &Denotes significant difference in LG group Pre-Intralipid/Baseline measure with respect to the OS group. *Denotes significant difference within group, Post-Intralipid measure with respect to the average Pre-Intralipid/Baseline measure. B. RQ measured under fasting conditions, with (CHO Diet) or without (Ad Lib Diet) high carbohydrate dietary intake, ±Glucose, and following Intralipid infusion. *Denotes significant difference within group, Post-Intralipid measure with respect to the average Pre-Intralipid measure. $Denotes significant difference in Post-Intralipid measure with respect to the Ad Lib Diet measure. #Denotes significant difference in Pre-Intralipid measure with respect to the Ad Lib Diet measure. C. Comparison of fasting RQ values (“Between Day”) and RQ values obtained during the saline or glucose infusion phase of the test visit (“Within Day”) to post-Intralipid RQ values. *Denotes significant difference within group, Post-Intralipid measure with respect to the Pre-Intralipid/Baseline measure. Note: For all symbols: *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. (DOCX 667 kb

Sugar-Functional Vinyl Addition Poly(norbornene)–Photopatternable Poly(norbornenyl gluconamide) Compositions Developed with Water

The norbornenyl gluconamide (NBGA) monomer can be polymerized by a number of palladium catalysts to give water-soluble, vinyl addition poly­(NBGA). Depending on the catalyst used, the reaction conditions, and the chain-transfer additives employed, high-molecular-weight polymers can be obtained. These polymers can be thermally cross-linked at ca. 190 °C or at ca. 150 °C when the difunctional glutaraldehyde is added. A photopatternable composition is formed by the addition of a water-soluble diazide when the poly­(NBGA) molecular weight is sufficiently high. After image-wise exposure, negative-tone patterns are revealed by water development. A detailed analysis of NBGA monomer structures by high-resolution nuclear magnetic resonance techniques including pure shift is reported showing that two diastereomers of each endo- and exo-isomer are formed from the reaction of norbornene methylamine and δ-gluconolactone

Causes of death as recorded in medical chart reported as percent of total deaths.

Causes of death as recorded in medical chart reported as percent of total deaths.</p