Preoperative Skin Conditioning: Extracellular Matrix Clearance and Skin Bed Preparation, A New Paradigm.

This paper introduces the concept of "skin bed preparation" prior to surgical procedures. Following the theory of chronic wound bed preparation and adapting the skin model to one of chronic wound changes related to extrinsic and intrinsic factors, a topical formulation aimed at recycling the extracellular matrix (ECM) from accumulated waste products is evaluated and discussed. The clearance of these products and stimulation of new replacements has the potential to change the regenerative milieu of the skin so that when procedures are carried out, cellular signaling and cross-talk at the dermal level are improved and healing is optimized. By introducing a combination of peptides and other synergistic active agents, a sequence of clearance, regeneration, and remodeling is initiated. This is confirmed and validated by a series of biopsies and clinical studies that demonstrate changes in the ECM as early as 2 to 3 weeks after application. Clinical studies related to resurfacing procedures show accelerated healing and improved symptomatic relief compared with standard of care by preconditioning the skin 2 weeks prior to the procedure. A similar approach is suggested as a potential advantage for invasive surgical procedures based on similar scientific principles elucidated on in the text

save to DISC: Documenting Innovation in Music Learning

The paper discusses an approach to determining the worth and value of innovation in music education and measuring it’s capacity for meaning and engagement. It also aims to identify new examples of innovation across a broad range of music learning contexts and establish a rigorous digital process for documenting, evaluating and distributing innovative cases and resources for present and future contexts. It discusses specifically a pilot project that seeks to document innovation in sound curriculum (DISC). save to DISC is an exploratory study in an Australasian CRC for Interaction Design (ACID) project that proposes to establish flexible and effective procedures for the sourcing, evaluating, refereeing, editing, producing, validating, storing, publishing, and distributing of a wide range of media and content types. It involves documenting innovative and successful practice in music education, creating and evaluating programs in difficult/challenging school contexts and commissioning and encouraging the production of resource materials for 21 st century contexts

Beyond Moral Fundamentalism: Dewey’s Pragmatic Pluralism in Ethics and Politics [preprint]

Drawing on unpublished and published sources from 1926-1932, this chapter builds on John Dewey’s naturalistic pragmatic pluralism in ethical theory. A primary focus is “Three Independent Factors in Morals,” which analyzes good, duty, and virtue as distinct categories that in many cases express different experiential origins. The chapter suggests that a vital role for contemporary theorizing is to lay bare and analyze the sorts of conflicts that constantly underlie moral and political action. Instead of reinforcing moral fundamentalism via an outdated quest for the central and basic source of normative justification, we should foster theories with a range of idioms and emphases which, while accommodating monistic insights, better inform decision-making by opening communication across diverse elements of moral and political life, placing these elements in a wider context in which norms gain practical traction in non-ideal conditions, and expanding prospects for social inquiry and convergence on policy and action