Support Networks of Primary Caregivers Receiving Family Preservation Services: An Exploratory Study

Copyright 1994 Families International, Inc.The authors describe network characteristics and support resources from a clinical sample of 40 families. Data were obtained by family workers during the first two weeks of intervention. Case vignettes illustrate the multiple uses to which this information was put. Implications for future research and practice are discussed

Do overweight and obese individuals demonstrate impaired thermoregulatory adaptation to six weeks of studio cycling training: a pilot study

High intensity interval training (HIIT) is effective at improving health markers in groups at risk of cardiovascular and metabolic disease. Studio cycling may offer a platform for HIIT in the community, however little is know about how increased adiposity influences thermal control during HIIT and the effect this may have on overweight patients who are new to exercise. The purpose of this pilot study was to investigate the thermal adaptation in response to studio based group HIIT in sedentary overweight adults

Adipocyte Derived Exosomes Promote Cell Invasion and Challenge Paclitaxel Efficacy in Ovarian Cancer

Background: Epithelial ovarian cancer (EOC) is the deadliest gynaecological cancer with high mortality rates driven by the common development of resistance to chemotherapy. EOC frequently invades the omentum, an adipocyte-rich organ of the peritoneum and omental adipocytes have been implicated in promoting disease progression, metastasis and chemoresistance. The signalling mechanisms underpinning EOC omentum tropism have yet to be elucidated. Methods: Three-dimensional co-culture models were used to explore adipocyte-EOC interactions. The impact of adipocytes on EOC proliferation, response to therapy and invasive capacity was assessed. Primary adipocytes and omental tissue were isolated from patients with ovarian malignancies and benign ovarian neoplasms. Exosomes were isolated from omentum tissue conditioned media and the effect of omentum-derived exosomes on EOC evaluated. Exosomal microRNA (miRNA) sequencing was used to identify miRNAs abundant in omental exosomes and EOC cells were transfected with highly abundant miRNAs miR-21, let-7b, miR-16 and miR-92a. Results: We demonstrate the capacity of adipocytes to induce an invasive phenotype in EOC populations through driving epithelial-to-mesenchymal transition (EMT). Exosomes secreted by omental tissue of ovarian cancer patients, as well as patients without malignancies, induced proliferation, upregulated EMT markers and reduced response to paclitaxel therapy in EOC cell lines and HGSOC patient samples. Analysis of the omentum-derived exosomes from cancer patients revealed highly abundant miRNAs that included miR-21, let-7b, miR-16 and miR-92a that promoted cancer cell proliferation and protection from chemotherapy when transfected in ovarian cancer cells.Conclusions: These observations highlight the capacity of omental adipocytes to generate a pro-tumorigenic and chemoprotective microenvironment in ovarian cancer and other adipose-related malignancies

Group studio cycling is an effective intervention to improve cardio-metabolic health in overweight sedentary individuals

Group studio cycling is an effective intervention to improve cardio-metabolic health in overweight sedentary individual

Investigation of combustion of emulated biogas in a gas turbine test rig

Combustion of biogas in gas turbines is an interesting option for provision of renewable combined heat and power from biomass. Due to an increasing share of fluctuating renewable energies in the power grid (especially from wind and solar power), flexible power generation is of increasing importance. Additionally, with an increasing share of agricultural and municipal waste in biogas production, biogas composition is expected to be within a broader range. In this paper, the combustion of synthetic biogas (carbon dioxide and methane) in a combustion test rig with a swirl burner and a high pressure optical chamber is researched at different conditions. Results are compared to a CHEMKIN-PRO simulation using a detailed reaction mechanism. The results show that within the researched experimental matrix, stable biogas combustion for gas turbines can be achieved even with significantly changing gas composition and nominal power. Carbon dioxide concentration is varied from 0 to 60%. CO concentrations (normalized to 15% O2) in the flue gas do not change significantly with increasing carbon dioxide in the fuel gas and, for the researched conditions, stayed below 10 ppm. NOx concentration is below 10 ppm (normalized to 15% O2) for pure methane, and is further decreasing with increasing carbon dioxide share in the fuel gas, which is mainly due to changing reaction paths as reaction analysis showed. Thermal load of the combustor is varied from 100% to 20% for the reference gas composition. With decreasing thermal load, normalized carbon monoxide flue gas concentration is further reduced, while NOx concentrations are remaining at a similar level around 5 ppm (normalized to 15% O2)

Muscular Adaptations to Concurrent Resistance Training and High-Intensity Interval Training in Adults with Type 2 Diabetes: A Pilot Study

This pilot study aimed to compare the effects of eight weeks of concurrent resistance training (RT) and high-intensity interval training (HIIT) vs. RT alone on muscle performance, mass and quality in adults with type 2 diabetes (T2DM). Twelve T2DM adults were randomly allocated to the RT + HIIT (n = 5) or RT (n = 7) group. Before and after training, maximal oxygen uptake (VO2max), muscle strength and power were evaluated by calorimetry, dynamometry and one-repetition maximum (1RM) test. Quadriceps muscle volume was determined by MRI, and muscle quality was estimated. After RT, VO2max (+12%), knee muscle power (+20%), quadriceps muscle volume (+5.9%) and quality (leg extension, +65.4%; leg step-up, +223%) and 1RM at leg extension (+66.4%), leg step-up (+267%), lat pulldown (+60.9%) and chest press (+61.2%) significantly increased. The RT + HIIT group improved on VO2max (+27%), muscle volume (+6%), muscle power (+9%) and 1RM at lat pulldown (+47%). No other differences were detected. Among groups, changes in muscle quality at leg step-up and leg extension and VO2max were significantly different. The combination of RT and HIIT effectively improves muscle function and size and increases cardiorespiratory fitness in adults with T2DM. However, HIIT combined with RT may interfere with the development of muscle quality

Muscular Adaptations to Concurrent Resistance Training and High-Intensity Interval Training in Adults with Type 2 Diabetes: A Pilot Study

This pilot study aimed to compare the effects of eight weeks of concurrent resistance training (RT) and high-intensity interval training (HIIT) vs. RT alone on muscle performance, mass and quality in adults with type 2 diabetes (T2DM). Twelve T2DM adults were randomly allocated to the RT + HIIT (n = 5) or RT (n = 7) group. Before and after training, maximal oxygen uptake (VO2max), muscle strength and power were evaluated by calorimetry, dynamometry and one-repetition maximum (1RM) test. Quadriceps muscle volume was determined by MRI, and muscle quality was estimated. After RT, VO2max (+12%), knee muscle power (+20%), quadriceps muscle volume (+5.9%) and quality (leg extension, +65.4%; leg step-up, +223%) and 1RM at leg extension (+66.4%), leg step-up (+267%), lat pulldown (+60.9%) and chest press (+61.2%) significantly increased. The RT + HIIT group improved on VO2max (+27%), muscle volume (+6%), muscle power (+9%) and 1RM at lat pulldown (+47%). No other differences were detected. Among groups, changes in muscle quality at leg step-up and leg extension and VO2max were significantly different. The combination of RT and HIIT effectively improves muscle function and size and increases cardiorespiratory fitness in adults with T2DM. However, HIIT combined with RT may interfere with the development of muscle quality

Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood

The platelet collagen receptor glycoprotein VI (GPVI) has been suggested to function as a dimer, with increased affinity for collagen. Dissociation constants (K(d)) obtained by measuring recombinant GPVI binding to collagenous substrates showed that GPVI dimers bind with high affinity to tandem GPO (Gly-Pro-Hyp) sequences in collagen, whereas the markedly lower affinity of the monomer for all substrates implies that it is not the collagen-binding form of GPVI. Dimer binding required a high density of immobilized triple-helical (GPO)(10)-containing peptide, suggesting that the dimer binds multiple, discrete peptide helices. Differential inhibition of dimer binding by dimer-specific antibodies, m-Fab-F and 204-11 Fab, suggests that m-Fab-F binds at the collagen-binding site of the dimer, and 204-11 Fab binds to a discrete site. Flow cytometric quantitation indicated that GPVI dimers account for ~29% of total GPVI in resting platelets, whereas activation by either collagen-related peptide or thrombin increases the number of dimers to ~39 and ~44%, respectively. m-Fab-F inhibits both GPVI-dependent static platelet adhesion to collagen and thrombus formation on collagen under low and high shear, indicating that pre-existing dimeric GPVI is required for the initial interaction with collagen because affinity of the monomer is too low to support binding and that interaction through the dimer is essential for platelet activation. These GPVI dimers in resting circulating platelets will enable them to bind injury-exposed subendothelial collagen to initiate platelet activation. The GPVI-specific agonist collagen-related peptide or thrombin further increases the number of dimers, thereby providing a feedback mechanism for reinforcing binding to collagen and platelet activation

Characterization of Additive Layer Manufacturing Swirl Burner Surface Roughness and Its Effects on Flame Stability Using High-Speed Diagnostics.

In this study, two Inconel 625 swirl nozzle inserts with identical bulk geometry were constructed via Additive Layer Manufacturing (ALM) for use in a generic gas turbine swirl burner. Further post-processing by grit blasting of one swirl nozzle insert results in a quantifiable change to the surface roughness characteristics when compared with the unprocessed ALM swirl nozzle insert or a third nozzle insert which has been manufactured using traditional machining methods. An evaluation of the influence of variable surface roughness effects from these swirl nozzle inserts is therefore performed under preheated isothermal and combustion conditions for premixed methane-air flames at thermal power of 25 kW. High-speed velocimetry at the swirler exit under isothermal conditions gives evidence of the change in near-wall boundary layer thickness and turbulent fluctuations resulting from the change in nozzle surface roughness. Under atmospheric combustion conditions, this influence is further quantified using a combination of dynamic pressure, high-speed OH* chemiluminescence, and exhaust gas emissions measurements to evaluate the flame stabilization mechanisms at the lean blowoff and rich stability limits. Notable differences in flame stabilization are evident as the surface roughness is varied, and changes in rich stability limit were investigated in relation to changes in the near-wall turbulence intensity. Results show that precise control of in-process or post-process surface roughness of wetted surfaces can positively influence burner stability limits and NOx emissions and must therefore be carefully considered in the ALM burner design process as well as CFD models

Prospectus, September 21, 1976

PC BOARD OF TRUSTEES OKS DEFICIT BUDGET; Anna Dearing of the LS testing lab: I enjoy it ; Write-ins dominate election, 1st Stu-Go meeting tommorow; PC news in brief: Sociological Association, First Meeting, Yea team!!!, Need some help?, Basketball tryouts; Women\u27s program sponsors : Antonia ; Improve reading at PC; Letters to the editor: The pins, Again..., And again?..., Oh no! not again?..., Give a Schmidt!!!, Where are the sports?; Editorial: Students are consumers; Quad fest featured music, magic; Counselors comply with Title IX; Prairie Festival set for Sunday; Louise Parker: \u27People are fun to watch\u27; Auditions today, tomorrow; Summer school in the Rockies; Drag races teach needed skills; 45 students attend: Marriott\u27s Great America attracts Parkland field trip; Ike\u27s opinion: Controversy continues: feedback on Dr. Richards; Uncle Bob: Slinging vegies is old tradition; Country crowd: Charlie and his fans; Mark Twain; Mediaseen: Carter and the media; Classifieds; Hoofers do \u27extremely well\u27 at UI; Women\u27s volleyball schedule; Locks and Dam 26 is subject of Oct. 12 debate; Know your athletes: \u27T\u27 Square keeps on running to own beat; Ten men: C-C members listed; Cobra\u27s Corner: Women\u27s volleyball improves; Cross Country Schedule 1976; Golfers fourth in tourney; Lose your nose?; Know your athletes: Kathy Kaler prepares for teaching; Linton wins Fast Fred; Fast Freddy\u27s Football Forecast; Games of September 25https://spark.parkland.edu/prospectus_1976/1011/thumbnail.jp