539 research outputs found
Roger that! Learning How Laypersons Teach New Functions to Intelligent Systems
Intelligent systems are rather smart today but still limited to built-in functionality. To break through this barrier, future systems must allow users to easily adapt the system by themselves. For humans the most natural way to communicate is talking. But what if users want to extend the systems’ functionality with nothing but natural language? Then intelligent systems must understand how laypersons teach new skills. To grasp the semantics of such teaching sequences, we have defined a hierarchical classification task. On the first level, we consider the existence of a teaching intent in an utterance; on the second, we classify the distinct semantic parts of teaching sequences: declaration of a new function, specification of intermediate steps, and superfluous information. We evaluate twelve machine learning techniques with multiple configurations tailored to this task ranging from classical approaches such as naı̈ve-bayes to modern techniques such as bidirectional LSTMs and task-oriented adaptations. On the first level convolutional neural networks achieve the best accuracy (96.6%). For the second task, bidirectional LSTMs are the most accurate (98.8%). With the additional adaptations we are able to improve both classifications distinctly (up to 1.8%)
Towards Programming in Natural Language: Learning New Functions from Spoken Utterances
Systems with conversational interfaces are rather popular nowadays. However, their full potential is not yet exploited. For the time being, users are restricted to calling predefined functions. Soon, users will expect to customize systems to their needs and create own functions using nothing but spoken instructions. Thus, future systems must understand how laypersons teach new functionality to intelligent systems. The understanding of natural language teaching sequences is a first step toward comprehensive end-user programming in natural language. We propose to analyze the semantics of spoken teaching sequences with a hierarchical classification approach. First, we classify whether an utterance constitutes an effort to teach a new function or not. Afterward, a second classifier locates the distinct semantic parts of teaching efforts: declaration of a new function, specification of intermediate steps, and superfluous information. For both tasks we implement a broad range of machine learning techniques: classical approaches, such as Naïve Bayes, and neural network configurations of various types and architectures, such as bidirectional LSTMs. Additionally, we introduce two heuristic-based adaptations that are tailored to the task of understanding teaching sequences. As data basis we use 3168 descriptions gathered in a user study. For the first task convolutional neural networks obtain the best results (accuracy: 96.6%); bidirectional LSTMs excel in the second (accuracy: 98.8%). The adaptations improve the first-level classification considerably (plus 2.2% points)
Overlapping Unit Cells in 3d Quasicrystal Structure
A 3-dimensional quasiperiodic lattice, with overlapping unit cells and
periodic in one direction, is constructed using grid and projection methods
pioneered by de Bruijn. Each unit cell consists of 26 points, of which 22 are
the vertices of a convex polytope P, and 4 are interior points also shared with
other neighboring unit cells. Using Kronecker's theorem the frequencies of all
possible types of overlapping are found.Comment: LaTeX2e, 11 pages, 5 figures (8 eps files), uses iopart.class. Final
versio
LumbSten: The lumbar spinal stenosis outcome study
BACKGROUND: Lumbar spinal stenosis is the most frequent reason for spinal surgery in elderly people. For patients with moderate or severe symptoms different conservative and surgical treatment modalities are recommended, but knowledge about the effectiveness, in particular of the conservative treatments, is scarce. There is some evidence that surgery improves outcome in about two thirds of the patients. The aims of this study are to derive and validate a prognostic prediction aid to estimate the probability of clinically relevant improvement after surgery and to gain more knowledge about the future course of patients treated by conservative treatment modalities.
METHODS/DESIGN: This is a prospective, multi-centre cohort study within four hospitals of Zurich, Switzerland. We will enroll patients with neurogenic claudication and lumbar spinal stenosis verified by Computer Tomography or Magnetic Resonance Imaging. Participating in the study will have no influence on treatment modality. Clinical data, including relevant prognostic data, will be collected at baseline and the Swiss Spinal Stenosis Questionnaire will be used to quantify severity of symptoms, physical function characteristics, and patient's satisfaction after treatment (primary outcome). Data on outcome will be collected 6 weeks, and 6, 12, 24 and 36 months after inclusion in the study. Applying multivariable statistical methods, a prediction rule to estimate the course after surgery will be derived.
DISCUSSION: The ultimate goal of the study is to facilitate optimal, knowledge based and individualized treatment recommendations for patients with symptomatic lumbar spinal stenosis
Incidence of Revision Surgery After Decompression With vs Without Fusion Among Patients With Degenerative Lumbar Spinal Stenosis.
Importance
Only limited data derived from large prospective cohort studies exist on the incidence of revision surgery among patients who undergo operations for degenerative lumbar spinal stenosis (DLSS).
Objective
To assess the cumulative incidence of revision surgery after 2 types of index operations-decompression alone or decompression with fusion-among patients with DLSS.
Design, Setting, and Participants
This cohort study analyzed data from a multicenter, prospective cohort study, the Lumbar Stenosis Outcome Study, which included patients aged 50 years or older with DLSS at 8 spine surgery and rheumatology units in Switzerland between December 2010 and December 2015. The follow-up period was 3 years. Data for this study were analyzed between October and November 2021.
Exposures
All patients underwent either decompression surgery alone or decompression with fusion surgery for DLSS.
Main Outcomes and Measures
The primary outcome was the cumulative incidence of revision operations. Secondary outcomes included changes in the following patient-reported outcome measures: Spinal Stenosis Measure (SSM) symptom severity (higher scores indicate more pain) and physical function (higher scores indicate more disability) subscale scores and the EuroQol Health-Related Quality of Life 5-Dimension 3-Level questionnaire (EQ-5D-3L) summary index score (lower scores indicate worse quality of life).
Results
A total of 328 patients (165 [50.3%] men; median age, 73.0 years [IQR, 66.0-78.0 years]) were included in the analysis. Of these, 256 (78.0%) underwent decompression alone and 72 (22.0%) underwent decompression with fusion. The cumulative incidence of revisions after 3 years of follow-up was 11.3% (95% CI, 7.4%-15.1%) for the decompression alone group and 13.9% (95% CI, 5.5%-21.5%) for the fusion group (log-rank P = .60). There was no significant difference in the need for revision between the 2 groups over time (unadjusted absolute risk difference, 2.6% [95% CI, -6.3% to 11.4%]; adjusted absolute risk difference, 3.9% [95% CI, -5.2% to 17.0%]; adjusted hazard ratio, 1.40 [95% CI, 0.63-3.13]). The number of revisions was significantly associated with higher SSM symptom severity scores (β, 0.171; 95% CI, 0.047-0.295; P = .007) and lower EQ-5D-3L summary index scores (β, -0.061; 95% CI, -0.105 to -0.017; P = .007) but not with higher SSM physical function scores (β, 0.068; 95% CI, -0.036 to 0.172; P = .20). The type of index operation was not significantly associated with the corresponding outcomes.
Conclusions and Relevance
This cohort study showed no significant association between the type of index operation for DLSS-decompression alone or fusion-and the need for revision surgery or the outcomes of pain, disability, and quality of life among patients after 3 years. Number of revision operations was associated with more pain and worse quality of life
Hybrid photonic-bandgap accelerating cavities
In a recent investigation, we studied two-dimensional point-defected photonic
bandgap cavities composed of dielectric rods arranged according to various
representative periodic and aperiodic lattices, with special emphasis on
possible applications to particle acceleration (along the longitudinal axis).
In this paper, we present a new study aimed at highlighting the possible
advantages of using hybrid structures based on the above dielectric
configurations, but featuring metallic rods in the outermost regions, for the
design of extremely-high quality factor, bandgap-based, accelerating
resonators. In this framework, we consider diverse configurations, with
different (periodic and aperiodic) lattice geometries, sizes, and
dielectric/metal fractions. Moreover, we also explore possible improvements
attainable via the use of superconducting plates to confine the electromagnetic
field in the longitudinal direction. Results from our comparative studies,
based on numerical full-wave simulations backed by experimental validations (at
room and cryogenic temperatures) in the microwave region, identify the
candidate parametric configurations capable of yielding the highest quality
factor.Comment: 13 pages, 5 figures, 3 tables. One figure and one reference added;
minor changes in the tex
Multifractal analysis of the electronic states in the Fibonacci superlattice under weak electric fields
Influence of the weak electric field on the electronic structure of the
Fibonacci superlattice is considered. The electric field produces a nonlinear
dynamics of the energy spectrum of the aperiodic superlattice. Mechanism of the
nonlinearity is explained in terms of energy levels anticrossings. The
multifractal formalism is applied to investigate the effect of weak electric
field on the statistical properties of electronic eigenfunctions. It is shown
that the applied electric field does not remove the multifractal character of
the electronic eigenfunctions, and that the singularity spectrum remains
non-parabolic, however with a modified shape. Changes of the distances between
energy levels of neighbouring eigenstates lead to the changes of the inverse
participation ratio of the corresponding eigenfunctions in the weak electric
field. It is demonstrated, that the local minima of the inverse participation
ratio in the vicinity of the anticrossings correspond to discontinuity of the
first derivative of the difference between marginal values of the singularity
strength. Analysis of the generalized dimension as a function of the electric
field shows that the electric field correlates spatial fluctuations of the
neighbouring electronic eigenfunction amplitudes in the vicinity of
anticrossings, and the nonlinear character of the scaling exponent confirms
multifractality of the corresponding electronic eigenfunctions.Comment: 10 pages, 9 figure
C8-glycosphingolipids preferentially insert into tumor cell membranes and promote chemotherapeutic drug uptake
AbstractInsufficient drug delivery into tumor cells limits the therapeutic efficacy of chemotherapy. Co-delivery of liposome-encapsulated drug and synthetic short-chain glycosphingolipids (SC-GSLs) significantly improved drug bioavailability by enhancing intracellular drug uptake. Investigating the mechanisms underlying this SC-GSL-mediated drug uptake enhancement is the aim of this study. Fluorescence microscopy was used to visualize the cell membrane lipid transfer intracellular fate of fluorescently labeled C6-NBD-GalCer incorporated in liposomes in tumor and non-tumor cells. Additionally click chemistry was applied to image and quantify native SC-GSLs in tumor and non-tumor cell membranes. SC-GSL-mediated flip-flop was investigated in model membranes to confirm membrane-incorporation of SC-GSL and its effect on membrane remodeling. SC-GSL enriched liposomes containing doxorubicin (Dox) were incubated at 4°C and 37°C and intracellular drug uptake was studied in comparison to standard liposomes and free Dox.SC-GSL transfer to the cell membrane was independent of liposomal uptake and the majority of the transferred lipid remained in the plasma membrane. The transfer of SC-GSL was tumor cell-specific and induced membrane rearrangement as evidenced by a transbilayer flip-flop of pyrene-SM. However, pore formation was measured, as leakage of hydrophilic fluorescent probes was not observed. Moreover, drug uptake appeared to be mediated by SC-GSLs. SC-GSLs enhanced the interaction of doxorubicin (Dox) with the outer leaflet of the plasma membrane of tumor cells at 4°C. Our results demonstrate that SC-GSLs preferentially insert into tumor cell plasma membranes enhancing cell intrinsic capacity to translocate amphiphilic drugs such as Dox across the membrane via a biophysical process
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