244 research outputs found
ORTHOTOPIC LIVER TRANSPLANTATION FOR WILSON'S DISEASE
An 11-year-old boy with terminal hepatic failure due to Wilson's disease was treated 18 months ago with orthotopic liver transplantation. Postoperatively, there has been evidence of clearance of body copper stores but without accumulation of copper in biopsy specimens of the transplanted liver after 6 and 17 months. Further follow-up will be necessary before deciding whether the disorder has been cured by liver replacement and in turn whether this constitutes proof that Wilson's disease is an inborn error of hepatic metabolism. The observations so far are consistent with these conclusions. © 1971
Gastrointestinal effects associated with soluble and insoluble copper in drinking water.
The aim of this study was to determine whether total copper or soluble copper concentration is associated with gastrointestinal signs and symptoms. Forty-five healthy adult women (18-55 years of age), living in Santiago, Chile, ingested tap water with 5 mg/L of copper containing different ratios of soluble copper (copper sulfate) and insoluble copper (copper oxide) over a 9-week period. Three randomized sequences of the different copper ratios (0:5, 1:4, 2:3, 3:2, and 5:0 mg/L) were followed. Subjects recorded their water consumption and gastrointestinal symptoms daily on a special form. Mean water consumption was similar among groups. Serum copper levels, ceruloplasmin, and activities of liver enzymes were within normal limits. No differences were detected between the means of biochemical parameters at the beginning and at the end of the study. Twenty subjects presented gastrointestinal disturbances at least once during the study, 9 suffered diarrhea (with or without abdominal pain and vomiting), and the other 11 subjects reported abdominal pain, nausea, or vomiting. No differences were found in incidence of abdominal pain, nausea, vomiting, and diarrhea regardless of the ratio of copper sulfate to copper oxide. In conclusion, both copper sulfate (a soluble compound) and copper oxide (an insoluble compound) have comparable effects on the induction of gastrointestinal manifestations, implying that similar levels of ionic copper were present in the stomach
Independent freezing of charge and spin dynamics in La1.5Sr0.5CoO4
We present elastic and quasielastic neutron scattering measurements
characterizing peculiar short-range charge-orbital and spin order in the
layered perovskite material La1.5Sr0.5CoO4. We find that below Tc~750 K holes
introduced by Sr doping lose mobility and enter a statically ordered {\it
charge glass} phase with loosely correlated checkerboard arrangement of empty
and occupied d{3z2-r2} orbitals (Co3+ and Co2+). The dynamics of the resultant
mixed spin system is governed by the anisotropic nature of the crystal-field
Hamiltonian and the peculiar exchange pattern produced by the orbital order. It
undergoes a {\it spin freezing} transition at much a lower temperature, Ts~30
K.Comment: 4 pages, 3 figures, Latex. Submitted to PR
Structural and Magnetic Instabilities of LaSrCaCuO
A neutron scattering study of nonsuperconducting
LaSrCaCuO (x=0 and 0.2), a bilayer copper oxide without CuO
chains, has revealed an unexpected tetragonal-to-orthorhombic transition with a
doping dependent transition temperature. The predominant structural
modification below the transition is an in-plane shift of the apical oxygen. In
the doped sample, the orthorhombic superstructure is strongly disordered, and a
glassy state involving both magnetic and structural degrees of freedom develops
at low temperature. The spin correlations are commensurate.Comment: published versio
Charge and orbital order in half-doped manganites
An explanation is given for the charge order, orbital order and insulating
state observed in half-doped manganese oxides, such as
NdSrMnO. The competition between the kinetic energy of
the electrons and the magnetic exchange energy drives the formation of
effectively one-dimensional ferromagnetic zig-zag chains. Due to a topological
phase factor in the hopping, the chains are intrinsically insulating and
orbital-ordered. Most surprisingly, the strong Coulomb interaction between
electrons on the same Mn-ion leads to the experimentally observed charge
ordering. For doping less than 1/2 the system is unstable towards phase
separation into a ferromagnetic metallic and charge-ordered insulating phase.Comment: To appear in Phys. Rev. Lett., 4 pages, 4 figure
- âŠ