Use of statistical package SAS: A case study from coconut research institute of Sri Lanka

The CRI began using microcomputers for the analysis of their experimental data in 1986. Four case studies of typical sets of field experimental data from the CRI are used to illustrate the potential benefits and possible problems in moving from a manual system of data processing to one which uses a powerful statistical package

Use of statistical package SAS:a case study from Coconut Resaerch Institute of Sri Lanka

The CRI began using microcomputers for the analysis of their experimental data in 1986. Four case studies of typical sets of field experimental data from the CRI are used to illustrate the potential benefits and possible problems in moving from a manual system of data processing to one which uses a powerful statistical package

Event-related potentials in autistic and healthy children on an auditory choice reaction time task

Introduction: Childhood autism can occur in 5 out of 10,000 of the population. The condition covers problems of sensory modulation, comprehension and communication as it relates to both objects and people. Of the stages of information processing recorded in auditory event-related potentials (ERPs), reductions of N1 and P3 amplitude have been reported in many situations, but an increased P3 response to non-targets may represent difficulties in attributing differentially significance to some but not all stimuli.. Methods: Recordings were derived from midline and 4 lateral sites on the scalp of 7 children with autism and 7/13 healthy control children matched for age (median 139 vs. 135 months). A three-tone oddball paradigm was presented in a passive and active-task form (72% at 1 kHz, 14% at 0.5 kHz and 14% at 2.0 kHz) Results: a) Autistic subjects showed twice as many errors of omission and a higher beta criterion (signal detection) for targets. b) For autistic subjects N1 latencies were shorter and N1 amplitude larger to deviants (especially nontargets). c) However, subtraction of the ERPs in nontarget from target conditions showed that the processing negativity (PN) and especially the Negative difference (Nd) was smaller in autistic subjects. d) In contrast the P3 amplitude (especially after the target) was smaller in autistic subjects. e) Within autistic subjects the topography showed more early negativity after deviants at left frontal sites and more target induced late positivity at right parietal sites. Conclusions: The ERPs of autistic children were more responsive to stimulus features (high frequency or deviance) and less responsive to the stimulus associations (target features). The ERPs also provide conflicting signs of neurodevelopment, -- precocious in the right-hemispheric emphasis for P3, but delayed in that P3 was not maximal at parietal sites

Event-related potentials and monoamines in autistic children on a clinical trial of fenfluramine

Introduction: As autistic persons have problems with selecting and encoding meaningful stimuli and multi-centre studies (Ritvo et al., 1983, 1986) had reported mild behavioural improvements following treatment with fenfluramine, event-related potential (ERP) stages of information processing were studied in childhood autism as part of a double blind crossover study of the efficacy of dl fenfluramine. . Methods: Acceptable recordings were derived from midline and 4 lateral sites on the scalp of 7 from 14 young persons with autism who understood the task (6 male, 1 female 5.8-17.7 years-of-age). A three-tone oddball paradigm was presented in a passive and active-task form (72% at 1 kHz, 14% at 0.5 kHz and 14% at 2.0 kHz) under placebo and drug conditions (where each condition lasted 5 months). Eleven patients provided blood and urine samples for monoamine analyses in both conditions. Results: a) With fenfluramine treatment blood serotonin decreased and urinary catecholamine levels fell (25-45%, but dopamine utilization (HVA/DA) increased 2-4-fold. b) Under fenfluramine autistic subjects responded non-significantly faster, with fewer errors of omission and improved /decreased beta criterion (signal detection). [IQ measures increased 7.5 points.] c) N1 amplitudes (Fz) decreased and latencies increased in the fenfluramine condition. Early negativity (especially on the right) correlated inversely with HVA/DA actvivity. Subtraction of the ERPs in nontarget from target conditions showed that the Negative difference (Nd) increased during fenfluramine treatment. d) P3 amplitudes (especially after the deviants) increased with fenfluramine treatment. But in the difference waveform (active-minus-passive condition) the P3 amplitude was halved. The distribution of the P3 component moved rostrally with treatment. Conclusions: N1 and P3 components of the ERP were responsive to fenfluramine treament. Treatment appears to have mildly improved early stimulus processing at stages represented by the early negative components, but to have mildly impaired processing at the P3-stage. The N1 / Nd - related improvement seems to be related to increased dopamine activity (cf. neuroleptic-like properties of racemate fenfluramine)

A controlled crossover trial of fendluramine in autism

Introduction: Against a background of variable results achieved by the treatment of childhood autism with dopaminergic agonists or antagonists, and opiate antagonists and mild behavioural improvements achieved following treatment with fenfluramine (Geller et al., 1982; Ritvo et al., 1984 among others) a 12 month double-blind crossover trial of fenfluramine was undertaken. [the d-isomer releases serotonin, the l-isomer modestly blocks dopamine receptors.] Methods: Six female and 14 male children and adolescents with autism were enrolled (median 9y; range 5-17 years of age) in a trial run over a 1 month baseline, 5 months of treatment, 2 months placebo, and 5 months of treatment. Parent diaries were kept. Various tests and rating scales for development, verbal and noverbal abilities along with measures of blood serotonin, urinary catecholamines and auditory event-related potentials (ERPs) were measured at 6-month intervals. Results: a) With fenfluramine treatment children lost weight, blood serotonin decreased by 60% and urinary catecholamine levels fell (25-45%, but dopamine utilization (HVA/DA) increased 2-4-fold. b) Under fenfluramine some autistic subjects improved on measures of cognitive and language function. Two mute subjects began to speak, but for the group overall the improvements did not prove significant. [British Ability Scale, Reynell developmental language and Vineland social maturity scale improvements were significant.] c) Treatment improved early stages of information processing, but impaired later stages as measured in the ERP (i.e. early negative going excitatory vs. later positive going inhibitory response, respectively in 7 patients). The early negativity changes (especially over the right hemisphere) correlated inversely with HVA/DA actvivity. d) Side effects reported included lethargy and irritability.. Conclusions: While individuals showed marked reductions of stereotypies, hyperactivity, and improvements on develepmental and cognitive measures, the absence of clear group-wide effects suggests that fenfluramine would have but a limited place in the management of some patients with autism

Diquark condensation at strong coupling

The possibility of diquark condensation at sufficiently large baryon chemical potential and zero temperature is analyzed in QCD at strong coupling. In agreement with other strong coupling analysis, it is found that a first order phase transition separates a low density phase with chiral symmetry spontaneously broken from a high density phase where chiral symmetry is restored. In none of the phases diquark condensation takes place as an equilibrium state, but, for any value of the chemical potential, there is a metastable state characterized by a non-vanishing diquark condensate. The energy difference between this metastable state and the equilibrium state decreases with the chemical potential and is minimum in the high density phase. The results indicate that there is attraction in the quark-quark sector also at strong coupling, and that the attraction is more effective at high baryon density, but for infinite coupling it is not enough to produce diquark condensation. It is argued that the absence of diquark condensation is not a peculiarity of the strong coupling limit, but persists at sufficiently large finite couplings.Comment: 10 pages, 2 figures. An important discussion concerning the extension of the results to finite couplings adde

Phase structure of lattice QCD for general number of flavors

We investigate the phase structure of lattice QCD for the general number of flavors in the parameter space of gauge coupling constant and quark mass, employing the one-plaquette gauge action and the standard Wilson quark action. Performing a series of simulations for the number of flavors $N_F=6$--360 with degenerate-mass quarks, we find that when $N_F \ge 7$ there is a line of a bulk first order phase transition between the confined phase and a deconfined phase at a finite current quark mass in the strong coupling region and the intermediate coupling region. The massless quark line exists only in the deconfined phase. Based on these numerical results in the strong coupling limit and in the intermediate coupling region, we propose the following phase structure, depending on the number of flavors whose masses are less than $\Lambda_d$ which is the physical scale characterizing the phase transition in the weak coupling region: When $N_F \ge 17$, there is only a trivial IR fixed point and therefore the theory in the continuum limit is free. On the other hand, when $16 \ge N_F \ge 7$, there is a non-trivial IR fixed point and therefore the theory is non-trivial with anomalous dimensions, however, without quark confinement. Theories which satisfy both quark confinement and spontaneous chiral symmetry breaking in the continuum limit exist only for $N_F \le 6$.Comment: RevTeX, 20 pages, 43 PS figure

Jet disc coupling in black hole binaries

In the last decade multi-wavelength observations have demonstrated the importance of jets in the energy output of accreting black hole binaries. The observed correlations between the presence of a jet and the state of the accretion flow provide important information on the coupling between accretion and ejection processes. After a brief review of the properties of black hole binaries, I illustrate the connection between accretion and ejection through two particularly interesting examples. First, an INTEGRAL observation of Cygnus X-1 during a 'mini-' state transition reveals disc jet coupling on time scales of orders of hours. Second, the black hole XTEJ1118+480 shows complex correlations between the X-ray and optical emission. Those correlations are interpreted in terms of coupling between disc and jet on time scales of seconds or less. Those observations are discussed in the framework of current models.Comment: Invited talk at the Fifth Stromlo Symposium: Disks, Winds & Jets - from Planets to Quasars. Accepted for publication in Astrophysics & Space Scienc

Searching for energetic cosmic axions in a laboratory experiment: testing the PVLAS anomaly

Astrophysical sources of energetic gamma rays provide the right conditions for maximal mixing between (pseudo)scalar (axion-like) particles and photons if their coupling is as strong as suggested by the PVLAS claim. This is independent of whether or not the axion interaction is standard at all energies or becomes supressed in the extreme conditions of the stellar interior. The flux of such particles through the Earth could be observed using a metre long, Tesla strength superconducting solenoid thus testing the axion interpretation of the PVLAS anomaly. The rate of events in CAST caused by axions from the Crab pulsar is also estimated for the PVLAS-favoured parameters.Comment: 5 pages, 3 figur