High Resolution Imaging of the Mitral Valve in the Natural State with 7 Tesla MRI

Imaging techniques of the mitral valve have improved tremendously during the last decade, but challenges persist. The delicate changes in annulus shape and papillary muscle position throughout the cardiac cycle have significant impact on the stress distribution in the leaflets and chords, thus preservation of anatomically accurate positioning is critical. The aim of this study was to develop an in vitro method and apparatus for obtaining high-resolution 3D MRI images of porcine mitral valves in both the diastolic and systolic configurations with physiologically appropriate annular shape, papillary muscle positions and orientations, specific to the heart from which the valve was harvested. Positioning and mounting was achieved through novel, customized mounting hardware consisting of papillary muscle and annulus holders with geometries determined via pre-mortem ultrasonic intra-valve measurements. A semi-automatic process was developed and employed to tailor Computer Aided Design models of the holders used to mount the valve. All valve mounting hardware was 3D printed using a stereolithographic printer, and the material of all fasteners used were brass for MRI compatibility. The mounted valves were placed within a clear acrylic case, capable of holding a zero-pressure and pressurized liquid bath of a MRI-compatible fluid. Obtaining images from the valve submerged in liquid fluid mimics the natural environment surrounding the valve, avoiding artefacts due to tissue surface tension mismatch and gravitational impact on tissue shape when not neutrally buoyant. Fluid pressure was supplied by reservoirs held at differing elevations and monitored and controlled to within ±1mmHg to ensure that the valves remained steady. The valves were scanned in a 7 Tesla MRI system providing a voxel resolution of at least 80μm. The systematic approach produced 3D datasets of high quality which, when combined with physiologically accurate positioning by the apparatus, can serve as an important input for validated computational models

Intermittent random walks for an optimal search strategy: One-dimensional case

We study the search kinetics of an immobile target by a concentration of randomly moving searchers. The object of the study is to optimize the probability of detection within the constraints of our model. The target is hidden on a one-dimensional lattice in the sense that searchers have no a priori information about where it is, and may detect it only upon encounter. The searchers perform random walks in discrete time n=0,1,2, ..., N, where N is the maximal time the search process is allowed to run. With probability \alpha the searchers step on a nearest-neighbour, and with probability (1-\alpha) they leave the lattice and stay off until they land back on the lattice at a fixed distance L away from the departure point. The random walk is thus intermittent. We calculate the probability P_N that the target remains undetected up to the maximal search time N, and seek to minimize this probability. We find that P_N is a non-monotonic function of \alpha, and show that there is an optimal choice \alpha_{opt}(N) of \alpha well within the intermittent regime, 0 < \alpha_{opt}(N) < 1, whereby P_N can be orders of magnitude smaller compared to the "pure" random walk cases \alpha =0 and \alpha = 1.Comment: 19 pages, 5 figures; submitted to Journal of Physics: Condensed Matter; special issue on Chemical Kinetics Beyond the Textbook: Fluctuations, Many-Particle Effects and Anomalous Dynamics, eds. K.Lindenberg, G.Oshanin and M.Tachiy

Metal-insulator transitions: Influence of lattice structure, Jahn-Teller effect, and Hund's rule coupling

We study the influence of the lattice structure, the Jahn-Teller effect and the Hund's rule coupling on a metal-insulator transition in AnC60 (A= K, Rb). The difference in lattice structure favors A3C60 (fcc) being a metal and A4C60 (bct) being an insulator, and the coupling to Hg Jahn-Teller phonons favors A4C60 being nonmagnetic. The coupling to Hg (Ag) phonons decreases (increases) the value Uc of the Coulomb integral at which the metal-insulator transition occurs. There is an important partial cancellation between the Jahn-Teller effect and the Hund's rule coupling.Comment: 4 pages, RevTeX, 3 eps figure, additional material available at http://www.mpi-stuttgart.mpg.de/docs/ANDERSEN/fullerene

ALMA polarimetric studies of rotating jet/disk systems

We have recently obtained polarimetric data at mm wavelengths with ALMA for the young systems DG Tau and CW Tau, for which the rotation properties of jet and disk have been investigated in previous high angular resolution studies. The motivation was to test the models of magneto-centrifugal launch of jets via the determination of the magnetic configuration at the disk surface. The analysis of these data, however, reveals that self-scattering of dust thermal radiation dominates the polarization pattern. It is shown that even if no information on the magnetic field can be derived in this case, the polarization data are a powerful tool for the diagnostics of the properties and the evolution of dust in protoplanetary disks.Comment: 9 pages, 3 figures, to appear in "Jet Simulations, Experiments and Theory. Ten years after JETSET, what is next ?", C. Sauty ed., Springer Natur

Electrical resistivity at large temperatures: Saturation and lack thereof

Many transition metal compounds show saturation of the resistivity at high temperatures, T, while the alkali-doped fullerenes and the high-Tc cuprates are usually considered to show no saturation. We present a model of transition metal compounds, showing saturation, and a model of alkali-doped fullerenes, showing no saturation. To analyze the results we use the f-sum rule, which leads to an approximate upper limit for the resistivity at large T. For some systems and at low T, the resistivity increases so rapidly that this upper limit is approached for experimental T. The resistivity then saturates. For a model of transition metal compounds with weakly interacting electrons, the upper limit corresponds to a mean free path consistent with the Ioffe-Regel condition. For a model of the high Tc cuprates with strongly interacting electrons, however, the upper limit is much larger than the Ioffe-Regel condition suggests. Since this limit is not exceeded by experimental data, the data are consistent with saturation also for the cuprates. After "saturation" the resistivity usually grows slowly. For the alkali-doped fullerenes, "saturation" can be considered to have happened already for T=0, due to orientational disorder. For these systems, however, the resistivity grows so rapidly after "saturation" that this concept is meaningless. This is due to the small band width and to the coupling to the level energies of the important phonons.Comment: 22 pages, RevTeX, 19 eps figures, additional material available at http://www.mpi-stuttgart.mpg.de/andersen/fullerene

Structure and properties of a novel fulleride Sm6C60

A novel fulleride Sm6C60 has been synthesized using high temperature solid state reaction. The Rietveld refinement on high resolution synchrotron X-ray powder diffraction data shows that Sm6C60 is isostructural with body-centered cubic A6C60 (A=K, Ba). Raman spectrum of Sm6C60 is similar to that of Ba6C60, and the frequencies of two Ag modes in Sm6C60 are nearly the same as that of Ba6C60, suggesting that Sm is divalent and hybridization between C60 molecules and the Sm atom could exist in Sm6C60. Resistivity measurement shows a weak T-linear behavior above 180 K, the transport at low temperature is mainly dominated by granular-metal theory.Comment: 9 pages, 3 figures, submitted to Phys. Rev. B (March 12, 1999

Long-range coupling and scalable architecture for superconducting flux qubits

Constructing a fault-tolerant quantum computer is a daunting task. Given any design, it is possible to determine the maximum error rate of each type of component that can be tolerated while still permitting arbitrarily large-scale quantum computation. It is an underappreciated fact that including an appropriately designed mechanism enabling long-range qubit coupling or transport substantially increases the maximum tolerable error rates of all components. With this thought in mind, we take the superconducting flux qubit coupling mechanism described in PRB 70, 140501 (2004) and extend it to allow approximately 500 MHz coupling of square flux qubits, 50 um a side, at a distance of up to several mm. This mechanism is then used as the basis of two scalable architectures for flux qubits taking into account crosstalk and fault-tolerant considerations such as permitting a universal set of logical gates, parallelism, measurement and initialization, and data mobility.Comment: 8 pages, 11 figure