Global Landscapes: Teaching Globalization through Responsive Mobile Map Design

<p>This article reports on the design and evaluation of Global Madison, a mobile map designed to support teaching and learning about globalization using Madison, Wisconsin, as a situated classroom. Our experience of place increasingly is mediated by mobile devices, opening new opportunities and challenges for research, industry, and education. Despite this rising popularity, few guidelines exist for creating and using mobile maps. Following tenets of user-centered design studies, we conducted two mixed-method evaluations of Global Madison to improve the tool and generate design insights that are potentially transferable to similar mobile mapping contexts: 244 students participated in an online survey after completing the tour and eighteen students were observed in the field. The evaluations generated new design considerations for mobile maps supporting situated learning, include: focus on critical issues that might leave students stranded, append location-based services with traditional mapping, enforce cognitive association between map and landscape, supply a consistent feed of information for new learners, encourage collaborative learning in the landscape, and promote student safety above all else.</p

A–D: Age-specific Prevalence of Group 1 and 2 High-risk HPVs and Lower-risk HPVs for 1262 Men Enrolled in the Multicenter AIDS Cohort Study Anal Health Sub-study.

<p>(A) Virus Type Group-specific Prevalence for All Men. (B–D) Comparison of 579 HIV-infected and 683–Uninfected Men for (B) Group 1 High-risk HPVs, (C) Group 2 High-risk HPVs, and (D) Lower-risk HPVs.</p

HPV-Infection Characteristics Among 1005 MACS MSM Showing One or More HPVs for Single and Multiply Detected HPV-Types.

a<p><i>p</i><0.05 Comparing prevalence of infection for HIV+ to HIV-negative men.</p

Sociodemographic Characteristics, Sexual Behavior Characteristics, HIV, and Human papillomavirus (HPV) infection Characteristics of 1262 Multicenter AIDS Cohort Study Participants Evaluated for HPV DNA using Anal Swab Specimens.

a<p><i>p</i><0.001, ^b<i>p</i> = 0.037, ^c<i>p</i><0.001, ^dcategories are not mutually exclusive, ^e<i>p</i> = 0.062; ^f<i>p</i> = 0.138^g<i>p</i><0.001. P-values for comparing HIV+ vs. HIV- were by the Fisher exact test or the Wilcoxon nonparametric test, as appropriate.</p

Comparison of Prevalence Ratios for Group 1 and 2 High-risk and Lower-risk HPVs for 579 HIV-infected Men Enrolled in the Multicenter AIDS Cohort Study Anal Health Sub-study.^a

<p>Comparison of Prevalence Ratios for Group 1 and 2 High-risk and Lower-risk HPVs for 579 HIV-infected Men Enrolled in the Multicenter AIDS Cohort Study Anal Health Sub-study.^a</p

Performance of extraction method MBT-CA for identification of Gram negative bacteria.

<p>*—extraction procedure not needed.</p><p>Performance of extraction method MBT-CA for identification of Gram negative bacteria.</p

Performance of MBT-CA System for identification of aerobic Gram negative rods.

<p>Performance of MBT-CA System for identification of aerobic Gram negative rods.</p

Design and Optimization of Selective Protein Kinase C θ (PKCθ) Inhibitors for the Treatment of Autoimmune Diseases

Protein kinase C θ (PKCθ) has a central role in T cell activation and survival; however, the dependency of T cell responses to the inhibition of this enzyme appears to be dictated by the nature of the antigen and by the inflammatory environment. Studies in PKCθ-deficient mice have demonstrated that while antiviral responses are PKCθ-independent, T cell responses associated with autoimmune diseases are PKCθ-dependent. Thus, potent and selective inhibition of PKCθ is expected to block autoimmune T cell responses without compromising antiviral immunity. Herein, we describe the development of potent and selective PKCθ inhibitors, which show exceptional potency in cells and in vivo. By use of a structure based rational design approach, a 1000-fold improvement in potency and 76-fold improvement in selectivity over closely related PKC isoforms such as PKCδ were obtained from the initial HTS hit, together with a big improvement in lipophilic efficiency (LiPE)

Details of MTB-CA System no ID strains.

<p>Details of MTB-CA System no ID strains.</p

Characteristics of 340 Men Who Have Sex with Men Who Were Tested for Anal HPV DNA and Free Testosterone by HPV16/18 Positivity.

<p>^a Positive for either HPV16 or HPV18 or both</p><p>^b Fisher’s Exact (2-sided) p-values: comparisons between groups in total population; NS: <i>p</i>≥0.05</p><p>^c HCV antibody positivity</p><p>Characteristics of 340 Men Who Have Sex with Men Who Were Tested for Anal HPV DNA and Free Testosterone by HPV16/18 Positivity.</p