47 research outputs found
Length distribution of the CNVs in Negrito from Peninsular Malaysia.
<p>Length distribution of the CNVs in Negrito from Peninsular Malaysia.</p
General characteristics of CNV and CNVR among 34 Negrito genomes from Peninsular Malaysia.
<p>*Merged: stringent CNV calls by at least 2 out of 3 algorithms applied.</p
UCSC Genome Browser view of CNV on chromosome 3p22.2.
<p>Figure produced by custom tracks listing CNV call of Negrito and uploaded to <a href="http://genome.ucsc.edu" target="_blank">http://genome.ucsc.edu</a>.</p
CNVR map of Negrito samples.
<p>The ideogram summarizes the distribution of CNVRs on each human chromosome. The red indicates copy number loss, the blue indicates copy number gain while the green indicates multi-allelic loci.</p
Length distribution of the CNVs unique to the Negrito from Peninsular Malaysia.
<p>Length distribution of the CNVs unique to the Negrito from Peninsular Malaysia.</p
Candidate genes primer sequences and copy number amplified in SyBr Green qPCR assay.
<p>WDR4 and QCNV4 showed copy number normal and therefore considered as false positive. QCNV2 was detected as a CN gain by microarray, inconsistent with the qPCR validation, therefore considered as false positive. Parentheses, unrounded copy number values calculated using the relative quantification, standard deviation.</p
Gene Ontology and pathway analyses on the gene set within the Negrito-specific CNVs using PANTHER and DAVID.
<p>(a) PANTHER analysis suggests a major involvement of the genes harboring the population specific CNVs in the immune system process and response to stimulus, as well as the metabolic process; (b) DAVID analysis suggests the involvement of the genes harboring the population specific CNVs in the transcription and regulation of RNA metabolic processes.</p
Pathways and biological processes of the genes underlying the population specific CNvs in Negrito from Peninsular Malysia.
<p>Analysis was performed using PANTHER DAVID.</p
Common CNV with significant difference in allele frequencies compare to the HapMap3 dataset.
<p>Common CNV with significant difference in allele frequencies compare to the HapMap3 dataset.</p
Population specific CNVs in 34 genomes of Negrito from Peninsular Malaysia.
<p>Position of CNVs were coordinated based on Human Genome Assembly NCBI (hg18).</p><p>*CNV frequencies calculated based on the 34 Negrito genomes genotyped.</p