315 research outputs found

    Oil Supply and Tax Incentive

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    macroeconomics, oil, tax incentive

    Examples of Nonisothermal Moisture Movement in Wood

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    Moisture content gradients in wood samples subjected to nonisothermal conditions were monitored over time in two separate experiments using sample material from 1) green ash and 2) southern yellow pine. The warm and cold environment temperatures were maintained at 80 F and -40 F for both experiments. The warm environment relative humidity was maintained at 40% during the ash experiment, and 70% during the southern yellow pine experiment. The cold environment relative humidity was not controlled, but was presumed to be nearly 100%. The temperature gradient through the samples was measured using embedded Type-T thermocouples, and the moisture content profile from the warm to cold surface was determined by sectioning sample material.Total average moisture content generally increased as a function of time, indicating that moisture flux into the sample through the warm surface was greater than flux out of the sample at the cold surface. Moisture accumulated toward the warm surface for the southern yellow pine, but was generally more evenly distributed through the depth for the ash samples. These differences were attributed to different warm environment relative humidity conditions maintained between the two experiments

    SNPMClust: Bivariate Gaussian Genotype Clustering and Calling for Illumina Microarrays

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    SNPMClust is an R package for genotype clustering and calling with Illumina microarrays. It was originally developed for studies using the GoldenGate custom genotyping platform but can be used with other Illumina platforms, including Infinium BeadChip. The algorithm first rescales the fluorescent signal intensity data, adds empirically derived pseudo-data to minor allele genotype clusters, then uses the package mclust for bivariate Gaussian model fitting. We compared the accuracy and sensitivity of SNPMClust to that of GenCall, Illumina's proprietary algorithm, on a data set of 94 whole-genome amplified buccal (cheek swab) DNA samples. These samples were genotyped on a custom panel which included 1064 SNPs for which the true genotype was known with high confidence. SNPMClust produced uniformly lower false call rates over a wide range of overall call rates

    Moisture Adsorption and Transport by Wood Due to a Thermal Gradient Caused by Air-to-Air Thermal Differences

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    An experiment was conducted in which a thermal gradient was established in wood by air-to-air temperature differences. A walnut board and a redwood board, each 3/4 inch thick and approximately 4 inches wide, were installed in a 1-inch-thick sheet of wood fiber insulation board employed as the lid of a chest-type freezer. The narrow edges of the boards were exposed to room air and freezer air, respectively. The MC profiles were periodically determined by removing cross sections from the boards and reducing them to thin slices. Moisture moved down the temperature gradient and against the concentration gradient. The average MC of the walnut and redwood boards increased 21% and 2%, respectively, during the 53-day test. The results showed that when wood is used as a thermal barrier, water vapor will enter the wood from the warm air and can be condensed in the wood if the necessary temperature profile exists. In certain applications of wood, this raises the possibility for free water accumulation in wood and the associated hazards. Moisture movement down a temperature gradient in wood is hypothesized to be a causative factor in the ceiling/partition separation problem with trusses in residential housing

    An Error-Components Three-Stage Least-Squares Model of Investment Allocation by Farm Households

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    This paper is an assessment of patterns of investment by farm households via an econometric model adapted from a land allocation approach of Holt (1999). This analysis will shed light on the importance of different classes of assets to farm household well-being, and show the reaction of farm households to a variety of market, international and government effects.Farm Management,

    Does Prehabilitation Prior to Ulnar Collateral Ligament Surgery Affect Return to Sport Rate or Time in Baseball Players with Partial UCL Tears?

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    Those who suffer a partial thickness ulnar collateral ligament (UCL) tear often undergo a period of nonoperative management including physical therapy rehabilitation. This treatment is aimed at optimizing range of motion (ROM) and strengthening the supporting structures around the elbow to help offload the UCL. Unfortunately, some of these patients fail nonoperative management and require surgical intervention. This creates a unique set of patients who essentially underwent “prehabilitation” prior to their UCL surgery. Prehabilitation is considered a period of structured physical therapy rehabilitation aimed at strengthening structures surrounding an injured tendon or ligament, to allow for dissipation of stress away from the repaired structure after surgery. Prehabilitation has been studied extensively and implemented into the clinical practice of anterior cruciate ligament (ACL) rehabilitation, and is being studied for other injuries as well. However, the efficacy of prehabilitation for UCL surgical patients with partial thickness UCL tears has not been evaluated. This chart review: - determines if baseball players with partial UCL tears who completed at least 4 weeks of prehabilitation prior to surgery (Prehab) had better return to play (RTP) rates and quicker return to sport (RTS) time than players who attempted 0-3 weeks of physical therapy prior to UCL surgery (No Prehab) - compares revision, reoperation, and patient reported outcomes between Prehab and No Prehab player

    Gene-folic acid interactions and risk of conotruncal heart defects: Results from the National Birth Defects Prevention Study

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    Conotruncal heart defects (CTDs) are heart malformations that affect the cardiac outflow tract and typically cause significant morbidity and mortality. Evidence from epidemiological studies suggests that maternal folate intake is associated with a reduced risk of heart defects, including CTD. However, it is unclear if folate-related gene variants and maternal folate intake have an interactive effect on the risk of CTDs. In this study, we performed targeted sequencing of folate-related genes on DNA from 436 case families with CTDs who are enrolled in the National Birth Defects Prevention Study and then tested for common and rare variants associated with CTD. We identified risk alleles in materna

    The effect of mesenchymal stromal cell sheets on the inflammatory stage of flexor tendon healing

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    BACKGROUND: The clinical outcomes following intrasynovial flexor tendon repair are highly variable. Excessive inflammation is a principal factor underlying the formation of adhesions at the repair surface and affecting matrix regeneration at the repair center that limit tendon excursion and impair tendon healing. A previous in-vitro study revealed that adipose-derived mesenchymal stromal cells (ASCs) modulate tendon fibroblast response to macrophage-induced inflammation. The goal of the current study was therefore to explore the effectiveness of autologous ASCs on the inflammatory stage of intrasynovial tendon healing in vivo using a clinically relevant animal model. METHODS: Zone II flexor tendon transections and suture repairs were performed in a canine model. Autologous ASC sheets were delivered to the surface of repaired tendons. Seven days after repair, the effects of ASCs on tendon healing, with a focus on the inflammatory response, were evaluated using gene expression assays, immunostaining, and histological assessments. RESULTS: ASCs delivered via the cell sheet infiltrated the host tendon, including the repair surface and the space between the tendon ends, as viewed histologically by tracking GFP-expressing ASCs. Gene expression results demonstrated that ASCs promoted a regenerative/anti-inflammatory M2 macrophage phenotype and regulated tendon matrix remodeling. Specifically, there were significant increases in M2-stimulator (IL-4), marker (CD163 and MRC1), and effector (VEGF) gene expression in ASC-sheet treated tendons compared with nontreated tendons. When examining changes in extracellular matrix expression, tendon injury caused a significant increase in scar-associated COL3A1 expression and reductions in COL2A1 and ACAN expression. The ASC treatment effectively counteracted these changes, returning the expression levels of these genes closer to normal. Immunostaining further confirmed that ASC treatment increased CD163(+) M2 cells in the repaired tendons and suppressed cell apoptosis at the repair site. CONCLUSIONS: This study provides a novel approach for delivering ASCs with outcomes indicating potential for substantial modulation of the inflammatory environment and enhancement of tendon healing after flexor tendon repair

    Differences in BVOC oxidation and SOA formation above and below the forest canopy

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    Gas-phase biogenic volatile organic compounds (BVOCs) are oxidized in the troposphere to produce secondary pollutants such as ozone (O3), organic nitrates (RONO2), and secondary organic aerosol (SOA). Two coupled zero-dimensional models have been used to investigate differences in oxidation and SOA production from isoprene and α-pinene, especially with respect to the nitrate radical (NO3), above and below a forest canopy in rural Michigan. In both modeled environments (above and below the canopy), NO3 mixing ratios are relatively small (< 0.5 pptv); however, daytime (08:00–20:00 LT) mixing ratios below the canopy are 2 to 3 times larger than those above. As a result of this difference, NO3 contributes 12 % of total daytime α-pinene oxidation below the canopy while only contributing 4 % above. Increasing background pollutant levels to simulate a more polluted suburban or peri-urban forest environment increases the average contribution of NO3 to daytime below-canopy α-pinene oxidation to 32 %. Gas-phase RONO2 produced through NO3 oxidation undergoes net transport upward from the below-canopy environment during the day, and this transport contributes up to 30 % of total NO3-derived RONO2 production above the canopy in the morning (∌ 07:00). Modeled SOA mass loadings above and below the canopy ultimately differ by less than 0.5 ”g m−3, and extremely low-volatility organic compounds dominate SOA composition. Lower temperatures below the canopy cause increased partitioning of semi-volatile gas-phase products to the particle phase and up to 35 % larger SOA mass loadings of these products relative to above the canopy in the model. Including transport between above- and below-canopy environments increases above-canopy NO3-derived α-pinene RONO2 SOA mass by as much as 45 %, suggesting that below-canopy chemical processes substantially influence above-canopy SOA mass loadings, especially with regard to monoterpene-derived RONO2
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