Additional file 2: Figure S1. of Effect of tiotropium on night-time awakening and daily rescue medication use in patients with COPD

Adjusted weekly mean rescue medication doses/24 h. A dose of rescue medication use was defined as one or two puffs of albuterol. Data are mean ± standard error. The means are adjusted for center effects and baseline. The overall mean is the average over the 13 weekly means. ***p < 0.001 for tiotropium versus placebo. (PDF 82 kb

Additional file 4: Table S2. of Effect of tiotropium on night-time awakening and daily rescue medication use in patients with COPD

Pearson’s correlation coefficients: night-time awakening scores and 36-item Short-Form Health Survey (SF-36) scores at baseline, Week 13, and overall (Weeks 1–13). (PDF 212 kb

Additional file 5: of Effect of tiotropium on night-time awakening and daily rescue medication use in patients with COPD

Energy–fatigue questionnaire results. Table S3 Adjusted mean energy–fatigue questionnaire scores assessed at baseline and Week 13 (Day 92). Table S4 Pearson’s correlation coefficients: night-time awakening scores and energy–fatigue questionnaire data. (PDF 207 kb

Additional file 1: Table S1. of Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis

Differentially expressed genes in PFD treatment lung fibroblast vs. control fibroblast. (DOCX 27 kb

Volcano plot of gene differentially expressed between statin users and non-users.

<p>The plot shows the log fold-change on the X-axis versus the unadjusted P values (on the–log10 scale) on the Y-axis. The blue and red dots represent genes that showed fold change in either direction that is greater than 0.05 and have unadjusted P value <0.01. Genes that had an FDR-adjusted P value less than 0.05 for differential expression are annotated on the graph.</p

GO biological processes’ enrichment among statin differentially expressed genes.

<p>Adjusted P value: The Benjamini Hochberg Adjusted P value. No. of genes: number of genes in this pathway present among the 18 genes tested.</p><p>GO biological processes’ enrichment among statin differentially expressed genes.</p

Statins’ differentially expressed genes at 10% FDR.

<p>LogFC: log 2 fold change. Adj.p.value: Benjamini Hochberg Adjusted P value</p><p>Statins’ differentially expressed genes at 10% FDR.</p

Study participants’ demographics.

<p>Continuous variables are shown as mean+ standard error of man (SEM). Difference in demographics between statin users and non-users was calculated using Student’s t-test for continuous variables and Chi-square test for categorical variables</p><p>Study participants’ demographics.</p