Association of 10 SNPs on 9p22 with abnormal TVU screening results.

<p>Per allele odds ratios obtained with an additive model restricted to the Caucasian population for the association of 9p22 SNPs with abnormal screening results are shown. Cases are women with suspicious screening results; controls are women with normal or non-suspicious screening results. Worst TVU results indicate abnormal TVU results at any screen during the 4-year follow-up. First TVU results indicate abnormal TVU results at the first screen a woman participated in. Incident TVU results are abnormal results among women that were normal or non-suspicious at the first screening. An asterisk indicates p-values lower than 0.005, the significance level after conservative Bonferroni correction.</p

LD-plot of 10 SNPs on 9p22 from individuals included in the analysis.

<p>The LD-plot was generated with Haploview based on r² of the 10 SNPs on 9p22 in 992 Caucasian women with genotyping information and transvaginal ultrasound results available.</p

Risk factors and screening results in the subgroup with SNP data.

<p>TVU = transvaginal ultrasound; Family hx = family history; PMH = Post-menopausal hormone; OC = oral contraceptive; GWAS = genome-wide association study.</p

Association of telomere length with melanoma in 53 melanoma-prone families¹.

1<p>ORs and P-values were obtained from conditional logistic regression with melanoma as the outcome variable.</p>2<p>Telomere tertile: Short: <0.53; Medium: 0.53–0.72; Long: >0.72.</p>3<p>Model 1: age at blood draw, gender, and DNA source adjustment.</p>4<p>Model 2: age at blood draw, gender, DNA source, CDKN2A, and solar injury adjustment.</p>5<p>Model 2: age at blood draw, gender, DNA source, CDKN2A, moles, solar injury, and MC1R adjustment.</p

Distribution of age, gender, <i>CDKN2A</i>, pigmentation phenotype, and sun exposure variables in 53 melanoma-prone families by CMM status.

1<p>P-values were obtained by comparing CMM cases to unaffected individuals using the chi-square test.</p

Association of telomere length with melanoma in 53 melanoma-prone families, stratified by <i>CDKN2A</i> status among cases¹.

1<p>ORs and P-values were obtained from conditional logistic regression with melanoma as the outcome variable. Age at blood draw, gender, DNA source, and solar injury adjustment.</p>2<p>Telomere tertile: Short: <0.53; Medium: 0.53–0.72; Long: >0.72.</p

Distribution of age, gender, <i>CDKN2A</i>, pigmentation phenotype, and sun exposure variables in 53 melanoma-prone families by telomere length, stratified by CMM status.

1<p>P-values were obtained by comparing individuals in the telomere tertiles using a generalized estimating equation accounting for familial correlation in the variance and adjusting for age at blood draw, gender, and DNA source.</p><p>Short: <0.53; Medium: 0.53–0.72; Long: >0.72.</p

Correlations between relative telomere length and age at blood draw in unaffected individuals and CMM cases.

<p><i>P</i> values were obtained from the Spearman correlation test.</p

Additional file 1: of Successful use of whole genome amplified DNA from multiple source types for high-density Illumina SNP microarrays

Supplementary Tables and Figures. (DOCX 898 kb

Selected characteristic of lung cancer cases and individually matched controls selected from the Shanghai Women’s Health Study (recruited between 1997–2000).

$<p>Spearman correlation (r) with telomere length in controls is −0.41(P<0.0001).</p>£<p>P value of spearman r with telomere length in controls >0.05.</p>‡<p>Family history of lung cancer in first degree relatives.</p>*<p>NOS indicates not otherwise specified.</p>†<p>NA indicates not available.</p>††<p>NA indicates not available, as only never-smoking subjects were genotyped.</p