Forest Plot.

<p>Forest plot showing individual and pooled relative risks of all-cause mortality with 95% confidence intervals across 12 randomized clinical trials of weight loss interventions. Three trials did not report deaths in one intervention arm and are not included in this figure.</p

Funnel Plot.

<p>Funnel plot of the point estimate and 95% confidence interval of 12 randomized clinical trials of intentional weight loss.</p

Study Selection Flowchart.

<p>Flowchart for the selection of eligible studies.</p

Characteristics of the overall analytical sample and by percentiles of nondense mammographic area.

<p>Comparisons between groups from ANOVA for continuous variables and Chi-Square test for categorical variables. P value from Wald statistic to test for an overall effect across percentiles of nondense mammographic area. ^a Log-transformed cm², ^b Square root-transformed cm² and percent. Abbreviations-BMI: body mass index, IQR: interquartile range</p

Spearman correlations (r) of age, continuous mammographic measures and BMI^<b>a</b>.

a<p>P<0.001 for all correlations. Abbreviation-BMI: body mass index </p

Associations between mammographic measures (per standard deviation difference) and risk of mortality.

<p>^a Model 1 unadjusted; ^b Model 2 age-adjusted; ^c Model 3 adjusted for age, education, race, smoking history, type of mammogram (xerogram versus x-ray), diabetes and heart disease. ^d Model 4 adjusted for Model 2 covariates plus body mass index. P value from Wald statistic. All statistical tests were two-sided. Abbreviations-CI: confidence interval, HR: hazard ratio.</p

Associations between percentiles of mammographic measures and risk of mortality.

<p>^a Model 1 unadjusted; ^b Model 2 age-adjusted; ^c Model 3 adjusted for age, education, race, smoking history, type of mammogram (xerogram versus x-ray), diabetes and heart disease. ^d Model 4 adjusted for Model 2 covariates plus body mass index. P value from Wald statistic to test for an overall effect of categories of mammographic measures. All statistical tests were two-sided. Abbreviations-CI: confidence interval, HR: hazard ratio.</p

^*Predictors of 400-meter gait speed.

*<p>only significant independent predictors of gait speed according to multiple regression.</p

Plot of (log)8-iso-PGF_2α concentrations versus adjusted predicted probability of depressed mood according to sex.

<p>Predicted probability and 95% Confidence Intervals (95%CIs) are adjusted for age, race, education, site, alcohol use, smoking, 3MSE, physical activity, BMI, cerebrovascular disease, CVD and diabetes.</p

Main characteristics of the study population.

a<p>from chi-square test or Kruskal-wallis ANOVA.</p