Adjoint sensitivity analysis of an ultrawideband antenna

The frequency domain finite element method using H(curl)-conforming finite elements is a robust technique for full-wave analysis of antennas. As computers become more powerful, it is becoming feasible to not only predict antenna performance, but also to compute sensitivity of antenna performance with respect to multiple parameters. This sensitivity information can then be used for optimization of the design or specification of manufacturing tolerances. In this paper we review the Adjoint Method for sensitivity calculation, and apply it to the problem of optimizing a Ultrawideband antenna

La Nación, el peronismo y los orígenes de la Guerra fría en Argentina

This article deals with the international dimension of Argentine domestic policies by exploring one of the strategies of the conservative daily newspaper La Nación, between 1946 and 1950, in order to challenge Juan Perón’s hegemony. La Nación presented the Peronist regime as akin to the totalitarian regimes established under the Soviet Union’s vigilance. This is not surprising, but revealing the complex ideological mechanisms employed by La Nación in its strategy is a noteworthy endeavor. This work will provide a thorough exploration of the process through which La Nación shifted from its former opposition to Peronism, initially identified as a Nazi-Fascist movement, to a new articulation of the regime as a totalitarian one. To some extent this was not so different from the strategy that the United States’ (US) intellectual elites were carrying out in order to justify their struggle against a former ally in war as a continuation of purpose and not a rupture. Yet, the most interesting aspect of this evolution in the Argentine case is that it emerged in an autonomous way as a result of specific national and international phenomena. This shows that the characteristics of the early phase of the Cold War were shaped by transnational processes of convergence rather than US hegemony alone.Este artículo analiza la dimensión internacional de la política interna argentina explorando la estrategia del diario conservador La Nación, entre 1946 y 1950 en su enfrentamiento con el gobierno de Juan Domingo Perón. La Nación presentó el régimen peronista como similar a los regímenes totalitarios establecidos bajo el control de la Unión Soviética. Esto no resulta sorprendente, pero comprender los complejos mecanismos ideológicos empleados por La Nación en esta estrategia es un objetivo relevante de investigación. Este artículo ofrece un análisis detallado del proceso que permitió a La Nación transformar su descripción del peronismo como un movimiento nazi-fascista a otro totalitario. De alguna manera este proceso caminó en paralelo a la estrategia de los intelectuales estadounidenses para justificar el conflicto con un antiguo aliado como una continuación de los mismos objetivos de la Segunda Guerra Mundial y no como una ruptura. Sin embargo, lo más interesante es que en el caso argentino esta evolución surgió de manera autónoma como resultado de condiciones específicas nacional y de una particular interpretación de los fenómenos internacionales. Esto muestra que algunas características de la Guerra Fría temprana fueron moldeadas por procesos transnacionales de convergencia y no por la hegemonía de los Estados Unidos en solitario

Urinary Ethyl Glucuronide Can Be Used as a Biomarker of Habitual Alcohol Consumption in the General Population

BACKGROUND: Alcohol consumption is a frequently studied risk factor for chronic diseases, but many studies are hampered by self-report of alcohol consumption. The urinary metabolite ethyl glucuronide (EtG), reflecting alcohol consumption during the past 72 h, is a promising objective marker, but population data are lacking. OBJECTIVE: The objective of this study was to assess the reliability of EtG as a marker for habitual alcohol consumption compared with self-report and other biomarkers in the general population. METHODS: Among 6211 participants in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort, EtG concentrations were measured in 24-h urine samples. EtG was considered positive when concentrations were ≥100 ng/mL. Habitual alcohol consumption was self-reported by questionnaire (categories: no/almost never, 1-4 units per month, 2-7 units per week, 1-3 units per day or ≥4 units per day). Plasma HDL cholesterol concentration, erythrocyte mean corpuscular volume (MCV), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT) were determined as indirect biomarkers of alcohol consumption. Sensitivity, specificity, positive and negative predictive value, and proportions of agreement between reported consumption and EtG were calculated. To test the agreement of EtG concentration and alcohol consumption in categories, linear regression analysis was performed. In addition, the association between EtG concentrations and indirect biomarkers was analyzed. RESULTS: Mean age was 53.7 y, and 52.9% of participants men. Of the self-reported abstainers, 92.3% had an EtG concentration <100 ng/mL. Sensitivity was 66.3%, positive predictive value was 96.3%, and negative predictive value was 47.4%. The proportion of positive agreement was 78.5%, and the proportion of negative agreement was 62.7%. EtG concentrations were linearly associated with higher categories of alcohol consumption (P-trend < 0.001), adjusted for age, sex, and renal function. EtG was positively related to MCV, HDL cholesterol, and GGT but not to AST and ALT concentrations. CONCLUSIONS: This study shows that urinary EtG is in reasonable agreement with self-reported alcohol consumption and therefore can be used as an objective marker of habitual alcohol consumption in the general population

Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users

© 2018 The Author(s) Purpose: The detection of a novel psychoactive substance, 2F-MT-45, a fluorinated analogue of the synthetic opioid MT-45, was reported in a single seized tablet. MT-45, 2F-, 3F- and 4F-MT-45 were synthesised and reference analytical data were reported. The in vitro and in vivo metabolisms of MT-45 and 2F-MT-45 were investigated. Method: The reference standards and seized sample were characterised using nuclear magnetic resonance spectroscopy, ultra-performance liquid chromatography–quadrupole time of flight mass spectrometry, gas chromatography–mass spectrometry, attenuated total reflectance-Fourier transform infrared spectroscopy and Raman spectroscopy. Presumptive tests were performed and physicochemical properties of the compounds determined. Metabolite identification studies using human liver microsomes, human hepatocytes, mouse hepatocytes and in vivo testing using mice were performed and identified MT-45 metabolites were confirmed in authentic human urine samples. Results: Metabolic pathways identified for MT-45 and 2F-MT-45 were N-dealkylation, hydroxylation and subsequent glucuronidation. The major MT-45 metabolites identified in human in vitro studies and in authenticated human urine were phase I metabolites and should be incorporated as analytical targets to existing toxicological screening methods. Phase II glucuronidated metabolites were present in much lower proportions. Conclusions: 2F-MT-45 has been detected in a seized tablet for the first time. The metabolite identification data provide useful urinary metabolite targets for forensic and clinical testing for MT-45 and allows screening of urine for 2F-MT-45 and its major metabolites to determine its prevalence in case work