Odds ratios and 95% confidence intervals for the association between serum 25(OH)D, DBP, and the 25(OH)D:DBP molar ratio and colorectal cancer risk in stratified models, ATBC Study.

<p>Unconditional logistic regression was used for all models. OR  =  odds ratio; CI  =  confidence interval.</p>1<p>Cut-points for season specific quartiles (nmol/L): winter  = Q1: ≤18.3, Q2: >18.3–≤26.9, Q3: >26.9–≤42.0, Q4: >42.0;</p><p>Summer  = Q1: ≤27.0, Q2: >27.0 and ≤38.7, Q3: >38.7–≤53.4, Q4: >53.4.</p>2<p>Model adjusted for matching factors of age at randomization and date of blood collection.</p>3<p>Model adjusted for age at randomization, date of blood collection, years of smoking, serum α-tocopherol, serum β-carotene, serum retinol, BMI, height, and physical activity.</p>4<p>Adjusted for same factors in model 2, with additional adjustment for quartiles of 25(OH)D or DBP.</p

Association between serum 25(OH)D, DBP, and the 25(OH)D:DBP molar ratio, and the risk of colorectal cancer, ATBC Study.

<p>Conditional logistic regression was used for all models. OR  =  odds ratio; CI  =  confidence interval.</p>1<p>Cut-points for season specific quartiles (nmol/L): winter  = Q1: ≤18.3, Q2: >18.3–≤26.9, Q3: >26.9–≤42.0, Q4: >42.0; summer  = Q1: ≤27.0, Q2: >27.0 and ≤38.7, Q3: >38.7–≤53.4, Q4: >53.4.</p>2<p>Conditioned on the matching factors age at randomization and date of blood collection.</p>3<p>Conditioned on the matching factors age at randomization and date of blood collection and adjusted for years of smoking, serum α-tocopherol, serum β-carotene, serum retinol, BMI, height, and physical activity.</p>4<p>Adjusted for factors in model 2 with additional adjustment for quartiles of 25(OH)D or DBP.</p

Select baseline characteristics of controls by quartile of serum vitamin D binding protein, ATBC Study, 1985-2004.

1<p>All values are medians or proportions.</p>2<p>Dietary and supplement intake data were available for 95% of subjects.</p>3<p>A proxy for free circulating 25(OH)D.</p

Association between thyroid hormones and risk of overall and aggressive prostate cancer.

*<p>- Information on cancer stage and grade available for cases diagnosed through July 2002.</p>†<p>- Conditioned on age and date of baseline blood draw.</p>‡<p>- Conditioned on age and date of baseline blood draw. Further adjusted for body mass index (kg/m2), serum concentrations of retinol, total cholesterol, alpha-tocopherol, and beta-carotene, cigarettes smoked per day, years smoked, family history of prostate cancer, physical activity, education, marital status, urban residence, total intake of energy, dietary vitamin D, fruit, vegetables, red meat, alcohol, and use of calcium supplements.</p>§<p>- Hypothyroid defined as TSH >3 µIU/mL and T4 <4.6 µg/dL. Hyperthyroid defined as TSH <0.3 µIU/mL and T4 >12 µg/dL.</p

Age-adjusted^* baseline^† characteristics by quintile of baseline serum thyroxine (T4).

*<p>- Directly standardized to the age distribution of the entire cohort. Values are means unless otherwise indicated.</p>†<p>- All characteristics are from the baseline questionnaire except family history which was collected during follow-up and is available for 889 men in this case control set. Baseline dietary data were available for 1,117 men, and 246 men claimed supplement use at baseline.</p

Age-adjusted^* baseline^† characteristics by quintile of baseline serum thyroid stimulating hormone (TSH).

*<p>- Directly standardized to the age distribution of the entire cohort. Values are means unless otherwise indicated.</p>†<p>- All characteristics are from the baseline questionnaire except family history which was collected during follow-up and is available for 889 men in this case control set. Baseline dietary data were available for 1,117 men, and 246 men claimed supplement use at baseline.</p

Hypothyroid and hyperthyroid hormone profiles by serum concentrations of T4 and TSH.

<p>Hypothyroid and hyperthyroid hormone profiles by serum concentrations of T4 and TSH.</p

Age-adjusted^* baseline^† characteristics by case-control status.

*<p>- Values are means unless otherwise indicated.</p>†<p>- All characteristics are from the baseline questionnaire except family history which was collected during follow-up and is available for 889 men in this case control set. Baseline dietary data were available for 1,117 men, and 246 men claimed supplement use at baseline.</p

Association between baseline serum α-tocopherol and γ-tocopherol and risk of prostate cancer, stratified by disease stage and grade, PLCO Study.

a<p>Odds ratios are based on unconditional logistic regression, adjusted for study center, serum cholesterol, serum β-carotene, age, time since initial screening, and year of blood draw.</p>b<p>Aggressive cases were defined as stage III or IV, or Gleason score ≥ 7.</p

Association between baseline serum α-tocopherol, γ-tocopherol, and the α-tocopherol:γ-tocopherol molar ratio and risk of prostate cancer, PLCO Study.

a<p>Odds ratios based on conditional logistic regression (conditioned on age, time since initial screening, and year of blood draw) and adjusted for study center, serum cholesterol and serum β-carotene.</p