Characteristics of 5015 GCKD study participants by eGFR categories.

<p>Data are mean (SD) for continuous variables and percentages (count) for categorical variables. Missing values in following variables (number of missings): BMI (57), atrial fibrillation (12), valvular heart disease (42), anemia & hemoglobin (145), serum albumin (1), heart rate (49), current smoker (12), alcohol intake (28), education (101).</p><p>Valvular heart disease: aortic stenosis (n = 73), aortic insufficiency (n = 142), mitral stenosis (n = 15), mitral insufficiency (n = 251), other (n = 169). Some individuals had more than one type of valvular heart disease.</p><p>Characteristics of 5015 GCKD study participants by eGFR categories.</p

Validation analyses within a subsample of the regional center Freiburg (n = 118).

<p>Data are percentages.</p><p>Reference is heart failure diagnosis based on abstraction of medical records of the treating nephrologists or former hospitalizations. Sensitivity is the proportion of patients with heart failure according to the respective evaluated definition out of the patients with heart failure according to the reference definition. Specificity is the proportion of patients without heart failure according to the respective definition out of the patients without heart failure according to the reference definition. Positive predictive value (PPV) is the proportion of patients with heart failure according to the reference definition out of the patients with heart failure according to the evaluated definition. Negative predictive value (NPV) is the proportion of patients without heart failure according to the reference definition out of the patients without heart failure according to the evaluated definition.</p><p>Validation analyses within a subsample of the regional center Freiburg (n = 118).</p

Multivariable adjusted analyses of factors associated with Gothenburg HF and self-reported HF (n = 4,604).

<p>Of 5,015 observations, values were missing values in BMI (57), valvular heart disease (42), anemia (145), serum albumin (1), education (101), heart rate (49), current smoker (12), alcohol intake (28).</p><p>Multivariable adjusted analyses of factors associated with Gothenburg HF and self-reported HF (n = 4,604).</p

Prevalence of heart failure in UACR categories, by gender, presence of diabetes mellitus and CHD.

<p>Data are percentages (count). P-values are provided for a comparison of characteristics within a given definition of HF, e.g. proportion of men and women with self-reported HF.</p><p>Prevalence of heart failure in UACR categories, by gender, presence of diabetes mellitus and CHD.</p

Composition of the Gothenburg score and proportions of GCKD participants within the cardiac score components.

<p>Composition of the Gothenburg score and proportions of GCKD participants within the cardiac score components.</p

Prevalence of heart failure across eGFR categories.

<p>The prevalence of both self-reported and Gothenburg score heart failure is higher with lower eGFR category, with Gothenburg heart failure observed at least twice as much in each category compared to self-report. P-trend was determined from logistic regressions of each heart failure definition on categorized eGFR.</p