2 research outputs found
Hierarchically Assembled Theranostic Nanostructures for siRNA Delivery and Imaging Applications
Dual functional hierarchically assembled nanostructures,
with two
unique functions of carrying therapeutic cargo electrostatically and
maintaining radiolabeled imaging agents covalently within separate
component building blocks, have been developed via the supramolecular
assembly of several spherical cationic shell cross-linked nanoparticles
clustered around a central anionic shell cross-linked cylinder. The
shells of the cationic nanoparticles and the hydrophobic core domain
of the anionic central cylindrical nanostructure of the assemblies
were utilized to complex negatively charged nucleic acids (siRNA)
and to undergo radiolabeling, respectively, for potential theranostic
applications. The assemblies exhibited exceptional cell transfection
and radiolabeling efficiencies, providing an overall advantage over
the individual components, which could each facilitate only one or
the other of the functions