Maternal iron homeostasis: Effect on placental development and function

Iron is an essential mineral that participates in oxygen transport, DNA synthesis and repair, and as a cofactor for various cellular processes. Iron deficiency is the most common nutritional deficiency worldwide. Due to blood volume expansion and demands from the fetal-placental unit, pregnant women are one of the populations most at risk of developing iron deficiency. Iron deficiency during pregnancy poses major health concerns for offspring, including intrauterine growth restriction and long-term health complications. Although the underlying mechanisms remain unclear, maternal iron deficiency may indirectly impair fetal growth through changes in the structure and function of the placenta. Since the placenta forms the interface between mother and baby, understanding how the placenta changes in iron deficiency may yield new diagnostic indices of fetal stress in affected pregnancies, thereby leading to earlier interventions and improved fetal outcomes. In this review, we compile current data on the changes in placental development and function that occur under conditions of maternal iron deficiency, and discuss challenges and perspectives on managing the high incidence of iron deficiency in pregnant women

LatentForensics: Towards frugal deepfake detection in the StyleGAN latent space

The classification of forged videos has been a challenge for the past few years. Deepfake classifiers can now reliably predict whether or not video frames have been tampered with. However, their performance is tied to both the dataset used for training and the analyst's computational power. We propose a deepfake detection method that operates in the latent space of a state-of-the-art generative adversarial network (GAN) trained on high-quality face images. The proposed method leverages the structure of the latent space of StyleGAN to learn a lightweight binary classification model. Experimental results on standard datasets reveal that the proposed approach outperforms other state-of-the-art deepfake classification methods, especially in contexts where the data available to train the models is rare, such as when a new manipulation method is introduced. To the best of our knowledge, this is the first study showing the interest of the latent space of StyleGAN for deepfake classification. Combined with other recent studies on the interpretation and manipulation of this latent space, we believe that the proposed approach can further help in developing frugal deepfake classification methods based on interpretable high-level properties of face images.Comment: 7 pages, 3 figures, 5 table

Experimental and Theoretical Investigation of Molecular Field Effects by Polarization-resolved Resonant Inelastic X-ray Scattering

We present a combined theoretical and experimental study of molecular field effects on molecular core levels. Polarization-dependent resonant inelastic x-ray scattering is observed experimentally after resonant K-shell excitation of CF3Cl and HCl. We explain the linear dichroism observed in spin-orbit level intensities as due to molecular field effects, including singlet-triplet exchange, and interpret this behavior in terms of population differences in the 2px,y,z inner-shell orbitals. We investigate theoretically the different factors that can affect the electronic populations and the dynamical R dependence of the spin-orbit ratio. Finally, the results obtained are used to interpret the L-shell absorption spectra of the two molecules

Linear Dichroism in Resonant Inelastic X-Ray Scattering to Molecular Spin-Orbit States

Polarization-dependent resonant inelastic x-ray scattering (RIXS) is shown to be a new probe of molecular-field effects on the electronic structure of isolated molecules. A combined experimental and theoretical analysis explains the linear dichroism observed in Cl 2p RIXS following Cl 1s excitation in HCl and CF3Cl as due to molecular-field effects, including singlet-triplet exchange, indicating polarized-RIXS provides a direct probe of spin-orbit-state populations applicable to any molecule

Angular and Dynamical Properties in Resonant Inelastic X-ray Scattering: Case Study of Chlorine-containing Molecules

Polarization-dependent resonant inelastic x-ray scattering (RIXS) has been shown to be a probe of molecular-field effects on the electronic structure of isolated molecules. In this experimental analysis we explain the linear dichroism observed in Cl 2p polarized RIXS following Cl 1s excitation of a series of chlorofluoromethanes (CF3Cl, CF2Cl2, CFCl3, and CCl4) as due to molecular-field effects, including singlet-triplet exchange. We present an approach to extract directly the 2p inner-shell electronic state populations from the experimental measurements. Using the angular properties of the measured KV emission we also are able to determine the value of the polarization anisotropy parameter βp for each resolved component of the KV emission spectra

A New Method to Derive Electronegativity from Resonant Inelastic X-ray Scattering

Electronegativity is a well-known property of atoms and substituent groups. Because there is no direct way to measure it, establishing a useful scale for electronegativity often entails correlating it to another chemical parameter; a wide variety of methods have been proposed over the past 80 years to do just that. This work reports a new approach that connects electronegativity to a spectroscopic parameter derived from resonant inelastic x-ray scattering. The new method is demonstrated using a series of chlorine-containing compounds, focusing on the Cl 2p−1LUMO1 electronic states reached after Cl 1s→LUMO core excitation and subsequent KL radiative decay. Based on an electron-density analysis of the LUMOs, the relative weights of the Cl 2pz atomic orbital contributing to the Cl 2p3/2 molecular spin-orbit components are shown to yield a linear electronegativity scale consistent with previous approaches

Fabrication of Octahedral Tantalum Cluster Film by Electrophoretic Deposition

The octahedral Ta6Br14.8H2O cluster, one of the [M6Li12La6]n- octahedrons (M= Nb, Ta; Li= halogen, La= halogen or chalcogen), exhibits interesting oxido-reduction properties in solution1. The application of the [Ta6Bri12]2+ cores has been potentially studied in biotechnologies2, optical devices3, photovoltaic cells4 and catalysis5. Originating from the expectation to block the UV and NIR light on low-emissivity window, the Ta6Br14.8H2O cluster thin film on ITO glass has been fabricated by electrophoretic deposition (EPD) process, a fairly rapid and low cost two-step process well-known for ceramic shaping, conductive surface coating and easily scalable to industrial level. The interesting characteristic has been recognized that the green [Ta6Bri12]2+ cores (adsorbing Ultra-Visible range) easily transfers to brown [Ta6Bri12]3+/4+ cores (absorbing near-infrared range) when dissolved in different solvents. Therefore, selecting the medium and optimizing the concentration of water in solvent to obtain the green homogeneous suspension with high dissolution is the main purpose of study. Considering the green color and transmittance of solution, as well as FE-SEM surface morphology of the green film, 0.02 mL H2O per mL acetone was selected as the optimal ratio to obtain the green transparent suspension and possibility to fabricate the green film by EPD process. However, the [Ta6Bri12]2+ green film has been essentially incorporated with poly vinyl pyrrolidone (PVP) in order to improve the dispersion of Ta6Br14.8H2O clusters inside the suspension and effectively prevent the performance of new [Ta6Bri12]3+/4+ clusters (brown-color) by oxidizing reactions. Reference [1] A. Vogler et al., Inorg. Chem., 1983, 23 (10), 1360. [2] J. Knablein et al., J. Mol. Biol., 1997, 270, 1. [3] S. Cordier et al., J. Inorg. Organomet. Polym., 2015, 25, 189. [4] A. Renaud et al., Chemistry Select., 2016, 1, 2284. [5] A. Barras et al., Appl. Catal. B: Environ., 2012, 123,

Resonant Inelastic X-ray Scattering of Methyl Chloride at the Chlorine K Edge

We present a combined experimental and theoretical study of isolated CH3Cl molecules using resonant inelastic x-ray scattering (RIXS). The high-resolution spectra allow extraction of information about nuclear dynamics in the core-excited molecule. Polarization-resolved RIXS spectra exhibit linear dichroism in the spin-orbit intensities, a result interpreted as due to chemical environment and singlet-triplet exchange in the molecular core levels. From analysis of the polarization-resolved data, Cl 2px, y and 2pz electronic populations can be determined

All-fiber molecular frequency reference at 2 μm based on a versatile laser modulation sideband locking and a hollow-core fiber gas cell

Sensing of atmospheric trace gases is crucial for climate monitoring and to predict global climate changes. The required global coverage and spatial resolution have driven the studies of space-borne differential absorption lidar (DIAL) instruments to remotely monitor atmospheric gases from a satellite to ground. The performance of such instruments is notably determined by the frequency stability and accuracy of a low-power continuous-wave laser that seeds the pulsed laser transmitter. For a CO2 DIAL, this reference laser needs to be stabilized with an adjustable frequency-detuning from the center of the probed molecular transition and the 2.05-μm spectral range is of high interest from a spectroscopic point-of-view [1].We have developed an all-fiber modulation sideband locking set-up enabling a laser to be locked at a controlled frequency detuning from the center of the CO2 R(30) transition at 2050.97 nm, selected for DIAL applications. The offset frequency can be directly tuned over a span ranging from some hundred MHz up to at least 3 GHz, which is the typical requirement for a space-borne CO2 DIAL. The method is depicted in Fig. 1a. It consists of a distributed feedback (DFB) laser, followed by an intensity electro-optic modulator (EOM) driven by a radio-frequency signal at fEOM provided by an amplified voltage-controlled oscillator (VCO). The EOM generates a pair of sidebands shifted by ±fEOM that are coupled into a reference gas cell. The sidebands are dithered by modulating the VCO at a frequency fm 40 kHz to implement wavelength modulation spectroscopy (WMS). An error signal is produced by demodulating the reference cell transmission signal to servo-lock one of the sidebands at the center of the transition. As a result, the unmodulated laser carrier is detuned from the transition linecenter by the frequency offset fEOM, which can be easily varied, thus making the system versatile

Maternal and cord blood hemoglobin as determinants of placental weight: A cross-sectional study

Background: Both high and low placental weights are associated with adverse pregnancy outcomes. Maternal hemoglobin levels can influence placental weight, but the evidence is conflicting. Since maternal hemoglobin does not invariably correlate with fetal/neonatal blood hemoglobin levels, we sought to determine whether cord blood hemoglobin or maternal hemoglobin status more closely associates with placental weight in women undergoing elective cesarean section at term. Methods: This was a cross-sectional study conducted at the Royal Alexandra Hospital, Edmonton, Canada, involving 202 women with term singleton pregnancies undergoing elective cesarean section. Maternal blood and mixed cord blood hemoglobin levels were analyzed using a HemoCue Hb201+ system. Birth weight, placental weight, one-and five-minute APGAR scores, American Society of Anesthesiologists physical state classification, maternal age, and maternal height were also recorded. Relationships between maternal and cord blood hemoglobin levels with placental weight, birth weight, and birth weight to placental weight ratio were the main outcome measures. Results: A total of 182 subjects were included in the analysis. Regression analysis showed that cord blood hemoglobin, but not maternal hemoglobin, was inversely related with placental weight (β = −2.4, p = 0.001) and positively related with the birth weight to placental weight ratio (β = 0.015, p = 0.001 and p = 0.63, respectively). Conclusions: Our findings suggest that measuring cord blood hemoglobin levels, rather than maternal hemoglobin levels, may provide important diagnostic information about in utero fetal adaptation to suboptimal placental function and neonatal health