Association of genetic risk scores with symptom dimensions and case-control status across thresholds.

**<p>p<.001.</p>*<p>p<.01.</p

Brain response during correct trials.

<p>A) Main effect of task transition: Regions of the brain that respond more strongly during switch compared to repeat trials in adolescents and adults (threshold T = 2.11, p<0.05, FDR-corrected, in 25 contiguous voxels, yellow colour scale). B) Main effect of congruence: Regions of the brain respond more strongly during congruent compared to incongruent trials in adolescents and adults (threshold T = 2.64, p<0.05, FDR-corrected, in 25 contiguous voxels, blue colour scale), and regions of the brain that respond more strongly during incongruent compared to congruent trials in adolescents and adults (threshold T = 2.97, p<0.05, FDR-corrected, in 25 contiguous voxels, red colour scale). C) Main effect of group in the subsample analysis (N = 45 error-prone adolescents and N = 28 adults): Regions of the brain that respond weaker in adolescents compared to adults (threshold T = 2.87, p<0.05, FDR-corrected, in 25 contiguous voxels, yellow colour scale).</p

Brain response during correct post-error/post-missing trials.

<p>Note that only 181 adolescents and 22 adults which made at least three mistakes were considered for this analysis. A) Regions of the brain during post-error/post-missing trials that show a significant negative correlation with overall ER (threshold T = 2.77, p<0.05, FDR-corrected, in 25 contiguous voxels) in adolescents. B) Correlation coefficients for the correlation between brain response during post-error/post-missing trials and overall ER for adolescents (blue) and adults (orange) in the peak voxels (sorted by t-values, please see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0088957#pone.0088957.s004" target="_blank">Table S4</a>). The correlations only reached significance in adolescents.</p

Procedure of the interference and switch task with two out of 16 possible stimuli.

<p>Procedure of the interference and switch task with two out of 16 possible stimuli.</p

Mean reaction times (A) and error rates (B) for the four different conditions resulting from the factors task transition and congruence in adolescents (blue) and adults (orange).

<p>Notes: rp – repeat, sw – switch, C – congruent, I – incongruent. The error bars indicate the area of one standard deviation around the mean.</p

Brain response during error trials.

<p>Note that only 181 adolescents and 22 adults who made at least 3 mistakes were considered for this analysis. A) Regions of the brain during error trials that show a significant negative correlation with overall ER (threshold T = 3.84, p<0.05, FDR-corrected, in 25 contiguous voxels) in adolescents. B) Correlation coefficients for the negative correlation between brain response during error trials and overall ER for adolescents (blue) and adults (orange) in the peak voxels (please see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0088957#pone.0088957.s003" target="_blank">Table S3</a>). The correlation only reached significance in adolescents.</p

Distribution of ROH lengths for the 15 individuals with <i>Froh</i>>.0625 in the sample (blue) and the expected lengths of autozygous segments for different levels of inbreeding (red and orange).

<p>Nearby ROHs that were broken up by a possible heterozygous SNP miscall were joined together. Assuming Haldane's recombination model, the length of an autozygous segment should follow an exponential distribution with mean equal to 1/(2×number of generations since the common ancestor) in Morgans. The figure shows that the distribution of ROH lengths among individuals with <i>Froh</i>>.0625 is most consistent with autozygosity caused by common ancestors between parents who lived ∼6 generations ago.</p

Distributions of ROH Lengths (left) and <i>Froh</i> (right) in the total sample.

<p>Distributions are based on ROHs from the imputed SNP data. For clarity, the distribution of <i>Froh</i> leaves omits 15 individuals who have <i>Froh</i>>.0625.</p

Descriptive statistics of SNPs and ROHs (derived from imputed data) across datasets.

†<p>82% of imputed SNPs used in overall ROH analysis were genotyped on at least one platform.</p

Slope estimates (the change in log odds for a 1% increase in <i>Froh</i>; points) and their 95% confidence intervals (bars) of <i>Froh</i> from imputed SNP data predicting schizophrenia for different SNP homozygosity thresholds of calling ROHs.

<p>Minimum SNP thresholds for full and reduced models are offset for clarity. All ROH thresholds were significant; the most significant result was for ROHs defined as being 65 or more homozygous SNPs in a row.</p