Биокинетические параметры показателей токсичности высоких доз метотрексата

Methotrexate is one of the most effective and widely used cytostatic drugs. However as all antineoplastic drugs it has very low therapeutic index and high toxicity. Kinetic parameters (rate constants, half-times of restoration and extreme values of concentrations at the beginning of methotrexate infusion) were estimated for biochemical markers It is the method of the quantitative assessment of the drug toxicity. The biokinetic findings allow to set an optimum time interval between infusions of methotrexate for minimization of toxicity at therapeutic efficacy keeping of the antineoplastic drug.Метотрексат является одним из наиболее эффективных и широко применяемых цитостатических препаратов. Однако, как и все противоопухолевые препараты, он имеет низкий терапевтический индекс и обладает высокой токсичностью. Дать количественную оценку токсичности препарата можно, используя кинетические характеристики (константа скорости восстановления и период полувосстановления до нормы, максимальное значение после введения препарата) биохимических показателей крови, специфичных для того или иного вида токсического проявления. В настоящей работе был применен биокинетический подход для оценки токсичности метотрексата. Полученные результаты дают возможность прогнозирования дозы и времени введения метотрексата и его антидота - лейковорина для снижения токсичности при сохранении максимальной эффективности

PHYSICAL WORKING CAPACITY OF CHILDREN OF YOUNG SCHOOL AGES WHICH ARE SWIMMING

In this article, we study the effect of complexes impact on the development of motor qualities, based on physical loads of varying power and intensity, on the physical working capacity of pupils in experimental group

Model of Development of Self-determination as the Basis of Prevention of Addictive Behavior of Adolescents in Contemporary Educational Organizations

The article presents the analysis of the current domestic research of the problem of self-determination. It is shown that adolescence is a sensitive period for the development of self-determination, but there are not enough studies of its dynamics at this age and ways of the formation. Self-determination is considered in the article as the opposite of addictive behavior, which makes it a resource in terms of prevention of pathological dependencies. Therefore, the proposed approach to optimization of the system of prevention in educational institutions through the development of self-determination in adolescence, based on the development of the spiritual fulfillment of the individual as the main stage of formation of the self. A model of interaction between education experts in the course of prevention of addictive behavior in educational organizations, reflecting the main stages of development of self-determination in the course of maintenance work

REGULAR OBSERVATION OF CHILDREN WITH BRONCHIAL ASTHMA BY ALLERGOLOGIST AND ITS INFLUENCE ON CLINICAL AND FUNCTIONAL PARAMETERS OF THE DISEASE AND CONSUMPTION OF HEALTHCARE RESOURCES

In real practice, treatment of patients with bronchial asthma (BA) is accompanied by unreasonable increase of healthcare resources consumption because of unplanned visits to the doctor due to health worsening, hospital treatment of exacerbations and emergency calls. Objective: to evaluate an effectiveness of children’s with bronchial asthma observations by allergologist. Methods: the dynamics of clinical and functional signs and frequency of emergency claims was analyzed in 115 children with BA who were observed by allergologist once in 3 months during one year. Results: in 3 months of regular observation by allergologist the number of children with day and night symptoms of BA and patients with daily rescue use of short-acting 2-agonists decreased, there were fewer children with limitations of physical activity. The number of patients with normal FEV1 increased in 6 months. Regular observation with allergologist resulted in reduction of number of patients with exacerbations and hospitalizations, shortening of acute period of BA and hospital stay, decreasing of emergency claims rate compared to those who were observed by GPs. Conclusion: regular observation by allergologist once in 3 months results in stabilization of clinical and functional state in patients with BA and decreases the consumption of emergency care resources.Key words: children, bronchial asthma, allergologist, clinical and functional state, healthcare resources.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (3): 55–59)</span

EFFECTIVENESS OF OBSERVATION OF CHILDREN WITH BRONCHIAL ASTHMA AND EVALUATION OF THEIR QUALITY OF LIKE BY ALLERGOLOGIST

(Voprosy sovremennoi pediatrii — Current Pediatrics. – 2010;9(4):168-170

EFFECTIVENESS OF OBSERVATION OF CHILDREN WITH BRONCHIAL ASTHMA AND EVALUATION OF THEIR QUALITY OF LIKE BY ALLERGOLOGIST

(Voprosy sovremennoi pediatrii — Current Pediatrics. – 2010;9(4):168-170)</span

Mechanisms of the influence of electroinsulation coatings on the magnetic properties of amorphous soft magnetic alloys

The influence of organic and inorganic coatings on the magnetic properties of amorphous Fe-B-Si-C and Fe-Co-Si-B alloys were investigated. The samples of these alloys were in as-quenched state and after heat treatment with or without magnetic field. The morphology of researched coatings was different : amorphous and crystal. The suggested mechanism of the influence of coating is connected with appearance of anisotropic pseudo - uniaxial stresses in a plane of ribbon which are caused by anisotropic arrangement of coating elements in surface of ribbons

Complex program for the prevention of the development and progression of refractive errors in school year children

T.K. Botabekova1, N.A. Aldasheva2, V.R. Abdullina1, I.S. Stepanova1, B.I. Isergepova2, Zh.S. Iskakbaeva2 1Kazakhstan-Russian Medical University, Almaty, Kazakhstan 2Kazakhstan Research Institute of Eye Diseases, Almaty, Kazakhstan Aim: to develop a complex preventive and therapeutic program for refractive errors in school year children. Patients and Methods: 1,760 pupils of elementary, secondary, and high school of eight schools of Almaty (1,302 pupils of gymnasiums and 458 pupils of general education schools and sport boarding school) were examined. The 1st step was a preventive screening. The 2nd step was a distant interactive screening by teachers. The 3rd step was an eye examination of schoolers with low vision. The efficacy of the detection of&nbsp;visual impairments in schoolers during preventive and distant computer screening was compared. In addition, significant indicators for visual impairment monitoring in schoolers were identified. A "Program for the Prevention of the Development and Progression of Refractive Errors in Schoolchildren" was developed. To evaluate its efficacy, 140 pupils of general education schools with refractive errors and 1,302 pupils of gymnasiums with refractive er rors or their high risk underwent eye examinations. In addition, to compare the effect of wearing glasses/contact lenses with full correction on the quality of&nbsp;life, 31 schoolers aged 12–17 with refractive errors were selected. Results: the rate of visual impairments was 28.4% among the pupils of general education schools and 31.3% among the pupils of gymnasiums. The most common refractive error was myopia (46.9% and 65.4%, respectively). As children moved through their school carrier, the proportion of myopia tended to increase. Accommodative dysfunction ranked second 48.5% and 29.7%, respectively). Time spent on distant screening was twice less compared to time spent on preventive screening. Visual acuity, cycloplegic refraction, reserves of relative accommodation, and axial length (measured by ultrasound) were indicators of visual impairments in children during monitoring. Poor general health was reported in 33% of children who wear glasses and 15% of children who wear&nbsp; contact lenses. Keywords: refractive errors, myopia, accommodation, schoolchildren, distant screening, prevention, vision correction with contact lenses. For citation: Botabekova T.K., Aldasheva N.A., Abdullina V.R. et al. Complex program for the prevention of the development and&nbsp;progression of refractive errors in school year children. Russian Journal of Clinical Ophthalmology. 2021;21(3):135–142 (in Russ.). DOI: 10.32364/2311-7729-2021-21-3-135-142. <br

Physicochemical study of ammonium dicobalt(II)-octa-molybdenum with the composition (NH4)2[Co(H2O)4]2[Mo8O27]•6H2O

Ammonium dicobalt(II)-octa-molybdenum with the composition (NH4)2[Co(H2O)4]2[Mo8O27]•6H2O (I) is synthesized and studied by X-ray diffraction, IR spectroscopy, and thermogravimetry. The compound crystallizes in a triclinic system with the following unit cell parameters: a = 8.62923(9) Å, b = 9.4795(10) Å, c = 12.2071(13) Å, α = 104.326(2)°, β = 109.910(2)°, γ = 100.820(2)°, V = = 868.18(16) Å3, ρ(calc.) = 3.071 g/cm3, Z = 1. Space group is P-1. IR spectroscopic and thermogravimetric analyses are performed. © 2015 Pleiades Publishing, Ltd