Some Binding Problems Abroad

published or submitted for publicatio

Structural and magnetic properties of LaFe0.5Cr0.5O3 studied by neutron diffraction, electron diffraction and magnetometry

The structural and magnetic properties of the perovskite type compound LaFe0.5Cr0.5O3 have been studied by temperature dependent neutron powder diffraction and magnetization measurements. Rietveld refinement of the neutron diffraction data shows that the compound crystallizes in an orthorhombic perovskite structure with a random positioning of the Fe and Cr cations at the B sublattice. The magnetic structure at 10 K is a collinear antiferromagnetic one with the magnetic moment per site being equal to 2.79(4) mu(B). Magnetisation measurements confirm the overall antiferromagnetic behaviour. Moreover, it indicates a weak uncompensated magnetic moment close to the transition temperature T-N approximate to 265 K. This moment can be described by a magnetic cluster state, which remains up to 550 K. Electron diffraction patterns along with high-resolution transmission electron microscopy images reveal that the crystallites are composed by domains of different orientation, which share the same cubic perovskite sub-cell reflections. (C) 2005 Elsevier Ltd. All rights reserve

Influence of oxygen defects on the structure and magnetic properties of Sr1-xBixCoO3-y (0.1

The synthesis and structural characterization of perovskite-related Sr1-xBixCoO3-y compounds in the compositional range 0.0

Prevalence of IgA-antiendomysium and IgA-antigliadin autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children and adolescents

Objective. This study was conducted to investigate the prevalence of celiac disease (CD) in children and adolescents at diagnosis of insulin- dependent diabetes mellitus (IDDM) before insulin treatment was started. Material and Methods. At diagnosis of IDDM, and before treatment was started, 115 children and adolescents were screened for IgA-antiendomysium (EMA) and IgA-antigliadin antibodies (AGA). Those found to be EMA-positive and/or AGA- positive were investigated further with intestinal biopsy. Results. Of the 115 patients, 2 had known CD at diagnosis of IDDM; of the remainder of patients, 6% (7/113) were found to be EMA-positive and 9% (10/113) were found to have AGA levels above normal. Of the 6 patients who underwent biopsy, 5 manifested villous atrophy. In addition, 2 patients with high EMA and AGA antibody titers refused biopsy, and 4 patients with low EMA and/or AGA titers were found to have normal titers at control before biopsy decision. Conclusion. Because the prevalence of CD at diagnosis of IDDM would seem to be 6% to 8%, screening for CD seems to be justified among patients with newly diagnosed IDDM

Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes

Myelodysplastic syndromes and chronic myelomonocytic leukemia are blood disorders characterized by ineffective hematopoiesis and progressive marrow failure that can transform into acute leukemia. The DNA methyltransferase inhibitor 5-azacytidine (AZA) is the most effective pharmacological option, but only ∼50% of patients respond. A response only manifests after many months of treatment and is transient. The reasons underlying AZA resistance are unknown, and few alternatives exist for non-responders. Here, we show that AZA responders have more hematopoietic progenitor cells (HPCs) in the cell cycle. Non-responder HPC quiescence is mediated by integrin α5 (ITGA5) signaling and their hematopoietic potential improved by combining AZA with an ITGA5 inhibitor. AZA response is associated with the induction of an inflammatory response in HPCs in vivo. By molecular bar coding and tracking individual clones, we found that, although AZA alters the sub-clonal contribution to different lineages, founder clones are not eliminated and continue to drive hematopoiesis even in complete responders

A Galactic Eclipse: The Small Magellanic Cloud Is Forming Stars in Two Superimposed Systems

The structure and dynamics of the star-forming disk of the Small Magellanic Cloud (SMC) have long confounded us. The SMC is widely used as a prototype for galactic physics at low metallicity, and yet we fundamentally lack an understanding of the structure of its interstellar medium (ISM). In this work, we present a new model for the SMC by comparing the kinematics of young, massive stars with the structure of the ISM traced by high-resolution observations of neutral atomic hydrogen (H i ) from the Galactic Australian Square Kilometre Array Pathfinder survey. Specifically, we identify thousands of young, massive stars with precise radial velocity constraints from the Gaia and APOGEE surveys and match these stars to the ISM structures in which they likely formed. By comparing the average dust extinction toward these stars, we find evidence that the SMC is composed of two structures with distinct stellar and gaseous chemical compositions. We construct a simple model that successfully reproduces the observations and shows that the ISM of the SMC is arranged into two superimposed, star-forming systems with similar gas mass separated by ∼5 kpc along the line of sight