61 research outputs found
Neuropilin-1 Modulates p53/Caspases Axis to Promote Endothelial Cell Survival
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF), one of the crucial pro-angiogenic factors, functions as a potent inhibitor of endothelial cell (EC) apoptosis. Previous progress has been made towards delineating the VPF/VEGF survival signaling downstream of the activation of VEGFR-2. Here, we seek to define the function of NRP-1 in VPF/VEGF-induced survival signaling in EC and to elucidate the concomitant molecular signaling events that are pivotal for our understanding of the signaling of VPF/VEGF. Utilizing two different in vitro cell culture systems and an in vivo zebrafish model, we demonstrate that NRP-1 mediates VPF/VEGF-induced EC survival independent of VEGFR-2. Furthermore, we show here a novel mechanism for NRP-1-specific control of the anti-apoptotic pathway in EC through involvement of the NRP-1-interacting protein (NIP/GIPC) in the activation of PI-3K/Akt and subsequent inactivation of p53 pathways and FoxOs, as well as activation of p21. This study, by elucidating the mechanisms that govern VPF/VEGF-induced EC survival signaling via NRP-1, contributes to a better understanding of molecular mechanisms of cardiovascular development and disease and widens the possibilities for better therapeutic targets
A Numerical Methodology to Fully Elucidate the Altered Wall Shear Stress in a Stented Coronary Artery
Electron microscopic immunohistochemical identification of endothelial cells in the rabbit.
In vivo aortic muscle cell growth kinetics. Differences between thoracic and abdominal segments after intimal injury in the rabbit.
The effect of hypophysectomy on experimental endothelial cell regrowth and intimal thickening in the rat.
Tissue-factor coagulant activity of cultured human endothelial and smooth muscle cells and fibroblasts
Inhibition of endothelial cell regrowth. Cessation of aortic endothelial cell replication after balloon catheter denudation.
Abnormal vasomotor changes early after coronary angioplasty. A quantitative arteriographic study of their time course.
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