Manhattan plots for markers with <i>P</i><0.0001 from epigenome-wide association study and genome-wide association study.

<p>Phenotypes include 11 sterols and 35 fatty acids measured at fasting.</p

Additional file 1: of Epigenome-wide association study of metabolic syndrome in African-American adults

Table S1. HyperGEN family structure. Table S2. Baseline characteristics of REGARDS study participants. Figure S1. Epigenome-wide association for metabolic syndrome among African-Americans in HyperGEN study (N = 606). Figure S2. Differences in mean DNA methylation (%) of (A) cg06500161 in ABCG1 and of (B) cg06638433 in IGF2BP1 gene by metabolic syndrome and components. (PDF 1194 kb

Top genome-wide association study (GWAS) and epigenome-wide association study (EWAS) results for fasting sterols and fatty acids.

<p>Chr, chromosome; FA, fatty acid.</p

Data from 40 Genetics of Lipid Lowering Drugs and Diet Network Study participants.

<p>1a (below the diagonal)-Pairwise correlation of fasting sterols (bold), fatty acids (bold), clinical lipids, inflammatory markers, and other clinical measures. 1b (above the diagonal)- Pairwise correlation of change in postprandial sterols (bold), fatty acids (bold), clinical lipids, and other clinical measures. Grey lines indicate clinical parameters not captured postprandially.</p

Additional file 2: Figure S1. of Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup’ik people

Distribution of predicted mean values (±standard deviation) of transformed 25(OH)D levels for rs10205487 genotypes within n-3 PUFA quartiles (n = 924). The X-axis shows the n-3 PUFA quartiles, and the Y-axis shows Box-Cox transformed 25(OH)D levels, with the colors of the bars corresponding to the genotype. (DOCX 68.9 kb

Top genome-wide association study (GWAS) and epigenome-wide association study (EWAS) results for postprandial sterols and fatty acids.

<p>Chr, chromosome; FA, fatty acid.</p

Average concentration (nmol/gram of sample) of TrueMass panel metabolites measured at fasting and 3.5 hours after a postprandial lipemia (PPL) challenge for 40 Genetics of Lipid Lowering Drugs and Diet Network Study participants.

<p>*direction of change in concentration of the metabolite after the PPL intervention.</p

Additional file 1: Table S1. of Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup’ik people

Actual and effective number of SNPs in each linkage region. (DOCX 13.3 kb

Additional file 3: Figure S2. of Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup’ik people

Distribution of predicted mean values (±standard deviation) of transformed parathyroid hormone levels for rs1353894 genotypes within n-3 PUFA quartiles (n = 924) with the colors of the bars corresponding to genotype. The X-axis shows the n-3 PUFA quartiles, and the Y-axis shows log-transformed parathyroid hormone levels, with the colors of the bars corresponding to the genotype. (DOCX 17 kb