3,160 research outputs found

    Updated channel numbering and readout partitioning for the Silicon Tracker

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    The channel numbering scheme and readout partioning for the LHCb Silicon Tracker is updated to take account of changes to the detector cabling that have occurred since the start of DC'06. In addition, several typographical errors in the previous note have been corrected

    Effect of Spatial Inhomogeneities on the Membrane Surface on Receptor Dimerization and Signal Initiation

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    Important signal transduction pathways originate on the plasma membrane, where microdomains may transiently entrap diffusing receptors. This results in a non-random distribution of receptors even in the resting state, which can be visualized as “clusters” by high resolution imaging methods. Here, we explore how spatial in-homogeneities in the plasma membrane might influence the dimerization and phosphorylation status of ErbB2 and ErbB3, two receptor tyrosine kinases that preferentially heterodimerize and are often co-expressed in cancer. This theoretical study is based upon spatial stochastic simulations of the two-dimensional membrane landscape, where variables include differential distributions and overlap of transient confinement zones (“domains”) for the two receptor species. The in silico model is parameterized and validated using data from single particle tracking experiments. We report key differences in signaling output based on the degree of overlap between domains and the relative retention of receptors in such domains, expressed as escape probability. Results predict that a high overlap of domains, which favors transient co-confinement of both receptor species, will enhance the rate of hetero-interactions. Where domains do not overlap, simulations confirm expectations that homo-interactions are favored. Since ErbB3 is uniquely dependent on ErbB2 interactions for activation of its catalytic activity, variations in domain overlap or escape probability markedly alter the predicted patterns and time course of ErbB3 and ErbB2 phosphorylation. Taken together, these results implicate membrane domain organization as an important modulator of signal initiation, motivating the design of novel experimental approaches to measure these important parameters across a wider range of receptor systems

    Measurement of the charge asymmetry in B±→ϕK±B±→ϕK± and search for B±→ϕπ±B±→ϕπ± decays

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    The CP-violating charge asymmetry in B±→ϕK±B±→ϕK± decays is measured in a sample of pp collisions at 7 TeV centre-of-mass energy, corresponding to an integrated luminosity of 1.0 fb−1 collected by the LHCb experiment. The result is ACP(B±→ϕK±)=0.022±0.021±0.009ACP(B±→ϕK±)=0.022±0.021±0.009, where the first uncertainty is statistical and the second systematic. In addition, a search for the B±→ϕπ±B±→ϕπ± decay mode is performed, using the B±→ϕK±B±→ϕK± decay rate for normalization. An upper limit on the branching fraction B(B±→ϕπ±)<1.5×10−7B(B±→ϕπ±)<1.5×10−7 is set at 90% confidence level

    NNSA ASC Exascale Environment Planning, Applications Working Group, Report February 2011

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    The scope of the Apps WG covers three areas of interest: Physics and Engineering Models (PEM), multi-physics Integrated Codes (IC), and Verification and Validation (V&amp;V). Each places different demands on the exascale environment. The exascale challenge will be to provide environments that optimize all three. PEM serve as a test bed for both model development and 'best practices' for IC code development, as well as their use as standalone codes to improve scientific understanding. Rapidly achieving reasonable performance for a small team is the key to maintaining PEM innovation. Thus, the environment must provide the ability to develop portable code at a higher level of abstraction, which can then be tuned, as needed. PEM concentrate their computational footprint in one or a few kernels that must perform efficiently. Their comparative simplicity permits extreme optimization, so the environment must provide the ability to exercise significant control over the lower software and hardware levels. IC serve as the underlying software tools employed for most ASC problems of interest. Often coupling dozens of physics models into very large, very complex applications, ICs are usually the product of hundreds of staff-years of development, with lifetimes measured in decades. Thus, emphasis is placed on portability, maintainability and overall performance, with optimization done on the whole rather than on individual parts. The exascale environment must provide a high-level standardized programming model with effective tools and mechanisms for fault detection and remediation. Finally, V&amp;V addresses the infrastructure and methods to facilitate the assessment of code and model suitability for applications, and uncertainty quantification (UQ) methods for assessment and quantification of margins of uncertainty (QMU). V&amp;V employs both PEM and IC, with somewhat differing goals, i.e., parameter studies and error assessments to determine both the quality of the calculation and to estimate expected deviations of simulations from experiments. The exascale environment must provide a performance envelope suitable both for capacity calculations (high through-put) and full system capability runs (high performance). Analysis of the results place shared demand on both the I/O as well as the visualization subsystems

    Study of the reaction pbar p -> phi phi from 1.1 to 2.0 GeV/c

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    A study has been performed of the reaction pbar p -> 4K using in-flight antiprotons from 1.1 to 2.0 GeV/c incident momentum interacting with a hydrogen jet target. The reaction is dominated by the production of a pair of phi mesons. The pbar p -> phi phi cross section rises sharply above threshold and then falls continuously as a function of increasing antiproton momentum. The overall magnitude of the cross section exceeds expectations from a simple application of the OZI rule by two orders of magnitude. In a fine scan around the xi/f_J(2230) resonance, no structure is observed. A limit is set for the double branching ratio B(xi -> pbar p) * B(xi -> phi phi) < 6e-5 for a spin 2 resonance of M = 2.235 GeV and Width = 15 MeV.Comment: 13 pages, 13 figures, 2 tables, Latex. To be published in Phys. Rev.

    Aging Studies for the Large Honeycomb Drift Tube System of the Outer Tracker of HERA-B

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    The HERA-B Outer Tracker consists of drift tubes folded from polycarbonate foil and is operated with Ar/CF4/CO2 as drift gas. The detector has to stand radiation levels which are similar to LHC conditions. The first prototypes exposed to radiation in HERA-B suffered severe radiation damage due to the development of self-sustaining currents (Malter effect). In a subsequent extended R&D program major changes to the original concept for the drift tubes (surface conductivity, drift gas, production materials) have been developed and validated for use in harsh radiation environments. In the test program various aging effects (like Malter currents, gain loss due to anode aging and etching of the anode gold surface) have been observed and cures by tuning of operation parameters have been developed.Comment: 14 pages, 6 figures, to be published in the Proceedings of the International Workshop On Aging Phenomena In Gaseous Detectors, 2-5 Oct 2001, Hamburg, German
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