Reconstruction of metabolic networks from high-throughput metabolite profiling data: in silico analysis of red blood cell metabolism

We investigate the ability of algorithms developed for reverse engineering of transcriptional regulatory networks to reconstruct metabolic networks from high-throughput metabolite profiling data. For this, we generate synthetic metabolic profiles for benchmarking purposes based on a well-established model for red blood cell metabolism. A variety of data sets is generated, accounting for different properties of real metabolic networks, such as experimental noise, metabolite correlations, and temporal dynamics. These data sets are made available online. We apply ARACNE, a mainstream transcriptional networks reverse engineering algorithm, to these data sets and observe performance comparable to that obtained in the transcriptional domain, for which the algorithm was originally designed.Comment: 14 pages, 3 figures. Presented at the DIMACS Workshop on Dialogue on Reverse Engineering Assessment and Methods (DREAM), Sep 200

Semileptonic b --> u decays: lepton invariant mass spectrum

We compute O(alpha_s^2) QCD corrections to the lepton invariant mass spectrum in the decay b --> u l nu_l, relevant for the determination of the CKM matrix element |V_{ub}|. Our method can also be used to evaluate moments of the lepton energy distribution with an O(alpha_s^2) accuracy. The abelian part of our result gives the neutrino invariant mass spectrum in the muon decay and, upon integration, the O(alpha^2) correction to the muon lifetime.Comment: 5 pages, revte

Higgs Decay to Top Quarks at O(\alpha_s^2)

Three-loop corrections to the scalar and pseudo-scalar current correlator are calculated. By applying the large momentum expansion mass terms up to order (m^2/q^2)^4 are evaluated analytically. As an application O(\alpha_s^2) corrections to the decay of a scalar and pseudo-scalar Higgs boson into top quarks are considered. It is shown that for a Higgs mass not far above the $t\bar{t}$ threshold these higher order mass corrections are necessary to get reliable results.Comment: Latex, 20 pages, 14 ps-figures. The complete paper, including figures, is also available via anonymous ftp at ftp://ttpux2.physik.uni-karlsruhe.de/ , or via www at http://www-ttp.physik.uni-karlsruhe.de/cgi-bin/preprints

Three-loop \beta-functions for top-Yukawa and the Higgs self-interaction in the Standard Model

We analytically compute the dominant contributions to the \beta-functions for the top-Yukawa coupling, the strong coupling and the Higgs self-coupling as well as the anomalous dimensions of the scalar, gluon and quark fields in the unbroken phase of the Standard Model at three-loop level. These are mainly the QCD and top-Yukawa corrections. The contributions from the Higgs self-interaction which are negligible for the running of the top-Yukawa and the strong coupling but important for the running of the Higgs self-coupling are also evaluated.Comment: 22 pages, 7 figures. Few extra citations are added; the plots are improved. Results in computer readable form can be retrieved from http://www-ttp.particle.uni-karlsruhe.de/Progdata/ttp12/ttp12-012

Theoretical Aspects of Standard-Model Higgs-Boson Physics at a Future e^+ e^- Linear Collider

The Higgs boson is the missing link of the Standard Model of elementary particle physics. We review its decay properties and production mechanisms at a future e^+ e^- linear collider and its e^- e^-, e^+- gamma, and gamma gamma modes, with special emphasis on the influence of quantum corrections. We also discuss how its quantum numbers and couplings can be extracted from the study of appropriate final states.Comment: 23 pages (Latex), 15 figures (Postscript), to appear in Int. J. Mod. Phys.

Performance of a 229 Thorium solid-state nuclear clock

The 7.8 eV nuclear isomer transition in 229 Thorium has been suggested as an etalon transition in a new type of optical frequency standard. Here we discuss the construction of a "solid-state nuclear clock" from Thorium nuclei implanted into single crystals transparent in the vacuum ultraviolet range. We investigate crystal-induced line shifts and broadening effects for the specific system of Calcium fluoride. At liquid Nitrogen temperatures, the clock performance will be limited by decoherence due to magnetic coupling of the Thorium nucleus to neighboring nuclear moments, ruling out the commonly used Rabi or Ramsey interrogation schemes. We propose a clock stabilization based on counting of flourescence photons and present optimized operation parameters. Taking advantage of the high number of quantum oscillators under continuous interrogation, a fractional instability level of 10^{-19} might be reached within the solid-state approach.Comment: 28 pages, 9 figure

High-Precision Charm-Quark Mass and QCD Coupling from Current-Current Correlators in Lattice and Continuum QCD

We use lattice QCD simulations, with MILC gluon configurations and HISQ c-quark propagators, to make very precise determinations of moments of charm-quark pseudoscalar, vector and axial-vector correlators. These moments are combined with new four-loop results from continuum perturbation theory to obtain several new determinations of the MSbar mass of the charm quark and of the MSbar coupling. We find m_c(3GeV)=0.986(10)GeV, or, equivalently, m_c(m_c)=1.268(9)GeV, both for n_f=4 flavors; and alpha_msb(3GeV,n_f=4)=0.251(6), or, equivalently, alpha_\msb(M_Z,n_f=5)=0.1174(12). The new mass agrees well with results from continuum analyses of the vector correlator using experimental data for e+e- annihilation (instead of using lattice QCD simulations). These lattice and continuum results are the most accurate determinations to date of this mass. Ours is also one of the most accurate determinations of the QCD coupling by any method.Comment: 12 pages, 5 figures, 5 table

Heavy-Light Meson Decay Constant from QCD Sum Rules in Three-Loop Approximation

In this paper we compute the decay constant of the pseudo-scalar heavy-light mesons in the heavy quark effective theory framework of QCD sum rules. In our analysis we include the recently evaluated three-loop result of order $\alpha_s^2$ for the heavy-light current correlator. The value of the bottom quark mass, which essentially limits the accuracy of the sum rules for $B$ meson, is extracted from the nonrelativistic sum rules for $\Upsilon$ resonances in the next-to-next-to-leading approximation. We find stability of our result with respect to all types of corrections and the specific form of the sum rule which reduces the uncertainty. Our results $f_B=206\pm 20$ MeV and $f_D=195\pm 20$ MeV for the $B$ and $D$ meson decay constants are in impressive agreement with recent lattice calculations.Comment: minor editorial changes, references added, to appear in PR

Virtual Top-Quark Effects on the H->bb-bar Decay at Next-to-Leading Order in QCD

By means of a heavy-top-quark effective Lagrangian, we calculate the three-loop corrections of O(alpha_s^2 G_F M_t^2) to the H->bb-bar partial decay width of the standard-model Higgs boson with intermediate mass M_H<<2M_t. We take advantage of a soft-Higgs theorem to construct the relevant coefficient functions. We present our result both in the MS-bar and on-shell schemes of mass renormalization. The MS-bar formulation turns out to be favourable with regard to the convergence behaviour. We also test a recent idea concerning the naive non-abelianization of QCD.Comment: 8 pages (Latex), 5 figures (Postscript