Möglichkeiten für die Reanalyse von Ergebnissen bildungssoziologischer Forschung aus der ehemaligen Akademie der Pädagogischen Wissenschaften

'Ausgehend von einem kurzen Überblick über die bildungssoziologische Forschung an der Akademie der Pädagogischen Wissenschaften der DDR werden einige Aspekte der Reanalyse der noch vorliegenden Daten dargestellt. Hierbei werden vor allem auf die Schule aus der Sicht der Schüler und Schülerinnen eingegangen und die sozialen Differenzierungen zwischen den Schulen behandelt.' (Autorenreferat)'After briefly surveying the socio-educational research at the Akademie der Pädagogischen Wissenschaften of the German Democratic Republic we will discuss some aspects concerning the reanalysing of the remaining data. There will be a detailed inspection into the pupils' views on their schools and the social differences between the schools.' (author's abstract)

Amp(1q) and tetraploidy are commonly acquired chromosomal abnormalities in relapsed multiple myeloma.

Long-term disease control in multiple myeloma (MM) is typically an unmet medical need, and most patients experience multiple relapses. Fluorescence in situ hybridization (FISH) is the standard technique to detect chromosomal abnormalities (CAs), which are important to estimate the prognosis of MM and the allocation of risk adapted therapies. In advanced stages, the importance of CAs needs further investigation. From 148 MM patients, two or more paired samples, at least one of which was collected at relapse, were analyzed by FISH. Using targeted next-generation sequencing, we molecularly investigated samples harboring relapse-associated CAs. Sixty-one percent of the patients showed a change in the cytogenetic profile during the disease course, including 10% who acquired high-risk cytogenetics. Amp(1q) (≥4 copies of 1q21), driven by an additional increase in copy number in patients who already had 3 copies of 1q21, was the most common acquired CA with 16% affected patients. Tetraploidy, found in 10% of the samples collected at the last time-point, was unstable over the course of the disease and was associated with TP53 lesions. Our results indicate that cytogenetic progression is common in relapsed patients. The relatively high frequency of amp(1q) suggests an active role for this CA in disease progression

Implementing evaluation in the context of sustainable development (I). The planning and commissioning procedure of evaluations with sustainable development as part of a Tool Box.

In the context of sustainable development, evaluations have particularly high relevance as complex issues have to be dealt with generally over an extended period of time. Furthermore, there is a growing demand to evaluate against the concept of sustainable development. Especially evaluations with sustainable development are a rather new type of evaluation, as the source of its evaluation questions and the criteria applied are rooted in the concept of sustainable development. Sustainability of a specific project or process is often highly case specific as sustainable development is determined by many often unique issues. However, evaluations would be highly inefficient, if they would have to be newly designed in every case. Thus it is necessary to determine and utilize the major issues for evaluations with sustainable development. This paper is part of a series of three papers - which can be used independently - that present the major common issues for evaluations with sustainable development in a Tool Box. The results presented here are based on outcomes of a research project funded by the "Austrian Science Fund". This paper includes the evaluation planning and commissioning procedure. It describes the steps from the idea to implementation of an evaluation with sustainable development. In the context of general requirements of evaluation planning and commissioning, the special features of evaluations with sustainable development are highlighted. (author's abstract)Series: Research Paper Series of the Research Focus Managing Sustainabilit

Informelle Gruppen Jugendlicher in der zweiten Haelfte der 80er Jahre in der DDR Forschungsberichte, Interviews

Der vorliegende Dokumentationsband fasst zwei unveraenderte Arbeitspapiere aus den Jahren 1988 und 1989 zusammen. Er gibt damit einen Einblick in die Lebenssituation Jugendlicher in den letzten Jahren des Bestehens der DDR. Im Mittelpunkt stehen Lebensaeusserungen, Einstellungen, Werte und Verhaltensmuster Jugendlicher; auch wenn es sich dabei um marginale Gruppen handelt, wird doch die 'Kompliziertheit jugendlicher Lebensweisen' deutlich. Der erste Bericht legt den Schwerpunkt auf die Frage nach den gesellschaftlichen Ursachen fuer das Entstehen informeller Gruppen im Jugendbereich, waehrend der zweite Bericht staerker nach individuellen Ursachen fragt. Bei den thematisierten informellen Gruppen handelt es sich um Punks, Skinheads, Heavy Metals, Grufties, Funkies, Freizeitcliquen und Fangruppen. Den Schwerpunkt des vorliegenden Bandes bilden Tonbandprotokolle von elf qualitativen Interviews, die in den Jahren 1987, 1988 und 1990 durchgefuehrt wurden. (ICE)SIGLEAvailable from UuStB Koeln(38)-20000106182 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Refinement of IntelliCage protocols for complex cognitive tasks through replacement of drinking restrictions by incentive-disincentive paradigms

The IntelliCage allows automated testing of cognitive abilities of mice in a social home cage environment without handling by human experimenters. Restricted water access in combination with protocols in which only correct responses give access to water is a reliable learning motivator for hippocampus-dependent tasks assessing spatial memory and executive function. However, water restriction may negatively impact on animal welfare, especially in poor learners. To better comply with the 3R principles, we previously tested protocols in which water was freely available but additional access to sweetened water could be obtained by learning a task rule. While this purely appetitive motivation worked for simple tasks, too many mice lost interest in the sweet reward during more difficult hippocampus-dependent tasks. In the present study, we tested a battery of increasingly difficult spatial tasks in which water was still available without learning the task rule, but rendered less attractive either by adding bitter tasting quinine or by increasing the amount of work to obtain it. As in previous protocols, learning of the task rule provided access to water sweetened with saccharin. The two approaches of dual motivation were tested in two cohorts of female C57BL/6 N mice. Compared to purely appetitive motivation, both novel protocols strongly improved task engagement and increased task performance. Importantly, neither of the added disincentives had an adverse impact on liquid consumption, health status or body weight of the animals. Our results show that it is possible to refine test protocols in the IntelliCage so that they challenge cognitive functions without restricting access to water.ISSN:1662-515

Berliner Schuelerstudie 1992

SIGLEUuStB Koeln(38)-940106712 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Lebensbedingungen und Lebensweise von Schuljugendlichen (mit einem partiellen Vergleich zu Lehrlingen)

SIGLEInformationszentrum Sozialwissenschaften, Berlin, B 2211- - T. 1, 2, 3 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Zur sozialistischen Lebensweise aelterer Schueler

SIGLEInformationszentrum Sozialwissenschaften, Berlin, B 2211- - T. 1, 2, 3 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Diacetin, a reliable cue and private communication channel in a specialized pollination system : signalling between oil flowers and oil bees

The interaction between floral oil secreting plants and oil-collecting bees is one of the most specialized of all pollination mutualisms. Yet, the specific stimuli used by the bees to locate their host flowers have remained elusive. This study identifies diacetin, a volatile acetylated glycerol, as a floral signal compound shared by unrelated oil plants from around the globe. Electrophysiological measurements of antennae and behavioural assays identified diacetin as the key volatile used by oil-collecting bees to locate their host flowers. Furthermore, electrophysiological measurements indicate that only oil-collecting bees are capable of detecting diacetin. The structural and obvious biosynthetic similarity between diacetin and associated floral oils make it a reliable cue for oil-collecting bees. It is easily perceived by oil bees, but cant be detected by other potential pollinators. Therefore, diacetin represents the first demonstrated private communication channel in a pollination system.Irmgard Schäffler, Kim E. Steiner, Mark Haid, Sander S. van Berkel, Günter Gerlach, Steven D. Johnson, Ludger Wessjohann, and Stefan Dötter