Scalable Spatial Super-Resolution using Entangled Photons

N00N states -- maximally path-entangled states of N photons -- exhibit spatial interference patterns sharper than any classical interference pattern. This is known as super-resolution. However, even with perfectly efficient number-resolving detectors, the detection efficiency of all previously demonstrated methods to measure such interference decreases exponentially with the number of photons in the N00N state, often leading to the conclusion that N00N states are unsuitable for spatial measurements. Here, we create spatial super-resolution fringes with two-, three-, and four-photon N00N states, and demonstrate a scalable implementation of the so-called ``optical centroid measurement'' which provides an in-principle perfect detection efficiency. Moreover, we compare the N00N-state interference to the corresponding classical super-resolution interference. Although both provide the same increase in spatial frequency, the visibility of the classical fringes decreases exponentially with the number of detected photons, while the visibility of our experimentally measured N00N-state super-resolution fringes remains approximately constant with N. Our implementation of the optical centroid measurement is a scalable method to measure high photon-number quantum interference, an essential step forward for quantum-enhanced measurements, overcoming what was believed to be a fundamental challenge to quantum metrology

A Case of CCDC6-RET Fusion Mutation in Adult Acute Lymphoblastic Leukemia (ALL), a Known Activating Mutation Reported in ALL

We report the case of a patient with B-Cell Acute Lymphoblastic Leukemia (ALL) who was found to harbor a gene fusion involving the CCDC6 and RET genes. Although the RET mutations have been identified before in othermalignancies, and it is thought to represent a driver mutation in these neoplasms, it has yet to be described in ALL. The identification of known fusion genes conferring activating tyrosine kinase activity in neoplasms can suggest potential therapeutic role of tyrosine kinase inhibitors (TKI), an approach that has been exploited in several other fusion genes

Precursor T-Cell acute lymphoblastic leukemia/lymphoma with rare presentation in the urinary bladder

We present the 16th reported case of Acute Lymphoblastic Leukemia (ALL) with involvement in the bladder. Our patient was a 22 year-old man with T-cell ALL with a mediastinal mass. He received hyperfractionated cyclophos-phamide, vincristine, doxorubicin, dexamethasone (HyperCVAD) with mediastinal radiation. Prior to starting maintenance, he relapsed in the bladder and marrow. He received a nelarabine-based induction regimen and achieved remission. This was followed by an unrelated 11/12 HLA-matched myeloablative allogeneic stem cell transplant. He is in complete remission for the past 409 days