Designing Hands-On Robotics Courses for Students with Visual Impairment or Blindness

School laboratories let students playfully experience the fundamentals of, for example, robotics, computer science, and technology-related topics. By working with LEGO Mindstorms, secondary school students get a chance to learn on a cognitive, emotional, and haptic level and gain experiences with the aid of even more advanced robotics. However, due to an impairment or lack of sight, it is hardly possible for some students to fully participate in a programming process or in building a robot. To overcome this unintentional discrimination, the interdisciplinary student laboratory “RoboScope” at RWTH Aachen University has teamed up with a group of experts to develop a barrier-free robotic course. Since then, the course has been tested and implemented based on concurrent evaluations and frequently held at RWTH and several other German schools. The presented work covers an overview of different kinds of visual impairment and lab settings and the development cycle of the courses at RWTH from design to testing, implementation, and further development regarding the evaluations. Evaluations show that students who are visually impaired or blind appreciate the opportunity to participate in the field of robotics. An insight into the evaluation concept that differs from “regular” courses in the “Roboscope,” as well as the results are used for further development

Unbalanced expression of glutathione peroxidase 4 and arachidonate 15-lipoxygenase affects acrosome reaction and In Vitro fertilization

Glutathione peroxidase 4 (Gpx4) and arachidonic acid 15 lipoxygenase (Alox15) are counterplayers in oxidative lipid metabolism and both enzymes have been implicated in spermatogenesis. However, the roles of the two proteins in acrosomal exocytosis have not been explored in detail. Here we characterized Gpx4 distribution in mouse sperm and detected the enzyme not only in the midpiece of the resting sperm but also at the anterior region of the head, where the acrosome is localized. During sperm capacitation, Gpx4 translocated to the post-acrosomal compartment. Sperm from Gpx4+/Sec46Ala mice heterozygously expressing a catalytically silent enzyme displayed an increased expression of phosphotyrosyl proteins, impaired acrosomal exocytosis after in vitro capacitation and were not suitable for in vitro fertilization. Alox15-deficient sperm showed normal acrosome reactions but when crossed into a Gpx4-deficient background spontaneous acrosomal exocytosis was observed during capacitation and these cells were even less suitable for in vitro fertilization. Taken together, our data indicate that heterozygous expression of a catalytically silent Gpx4 variant impairs acrosomal exocytosis and in vitro fertilization. Alox15 deficiency hardly impacted the acrosome reaction but when crossed into the Gpx4-deficient background spontaneous acrosomal exocytosis was induced. The detailed molecular mechanisms for the observed effects may be related to the compromised redox homeostasis