399 research outputs found
A novel time series approach to bridge coding changes with a consistent solution across causes of death
Revisions of the International Classification of Diseases (ICD) can lead to biases in cause-specific mortality levels and trends. We propose a novel time series approach to bridge ICD coding changes which provides a consistent solution across causes of death. Using a state space model with interventions, we performed time series analysis to cause-proportional mortality for ICD9 and ICD10 in the Netherlands (1979–2010), Canada (1979–2007) and Italy (1990–2007) on chapter level. A constraint was used to keep the sum of cause-specific interventions zero. Comparability ratios (CRs) were estimated and compared to existing bridge coding CRs for Italy and Canada. A significant ICD9 to ICD10 transition occurred among 13 cause of death groups in Italy, 7 in Canada and 3 in the Netherlands. Without the constraint, all-cause mortality after the classification change would be overestimated by 0.4 % (NL), 0.03 % (Canada) and 0.2 %(Italy).ThetimeseriesCRswereinthesamedirectionasthebridgecodingCRsbut deviated more from 1. A smooth corrected trend over the ICD-transition resulted from applying the time series approach. Comparing the time series CRs for Italy (2003), Canada (1999) and the Netherlands (1995) revealed interesting commonalities and dif- ferences. We demonstrated the importance of adding the constraint, the validity of our methodology and its advantages above earlier methods. Applying the method to more specific causes of death and integrating medical content to a larger extent is advocated
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Managing Decommissioning Projects Using D&D Trak
Numerous buildings throughout the DOE complex are being decommissioned. The decommissioning process typically includes dismantling equipment and utility systems for disposal, decontaminating remaining surfaces to meet regulatory limits, demolishing the building structure, and remediating the surrounding environment to address any historical releases. Typically, a large amount of information and radiation survey data needs to be processed and evaluated. Rapid assessment of project information is required to effectively manage unanticipated conditions that are frequently encountered as building components are dismantled. Parsons has developed a relational database called D&D TRAK to estimate, plan, manage, and track decommissioning projects. D&D TRAK has been successfully used at DOE and other federal facilities to terminate radioactive licenses thus allowing the unrestricted free-release of these buildings to public and private sectors
A Novel Time Series Approach to Bridge Coding Changes with a Consistent Solution Across Causes of Death
Revisions of the International Classification of Diseases (ICD) can lead to biases in cause-specific mortality levels and trends. We propose a novel time series approach to bridge ICD coding changes which provides a consistent solution across causes of death. Using a state space model with interventions, we performed time series analysis to cause-proportional mortality for ICD9 and ICD10 in the Netherlands (1979–2010), Canada (1979–2007) and Italy (1990–2007) on chapter level. A constraint was used to keep the sum of cause-specific interventions zero. Comparability ratios (CRs) were estimated and compared to existing bridge coding CRs for Italy and Canada. A significant ICD9 to ICD10 transition occurred among 13 cause of death groups in Italy, 7 in Canada and 3 in the Netherlands. Without the constraint, all-cause mortality after the classification change would be overestimated by 0.4 % (NL), 0.03 % (Canada) and 0.2 % (Italy). The time series CRs were in the same direction as the bridge coding CRs but deviated more from 1. A smooth corrected trend over the ICD-transition resulted from applying the time series approach. Comparing the time series CRs for Italy (2003), Canada (1999) and the Netherlands (1995) revealed interesting commonalities and differences. We demonstrated the importance of adding the constraint, the validity of our methodology and its advantages above earlier methods. Applying the method to more specific causes of death and integrating medical content to a larger extent is advocated
Carbohydrate supplementation during prolonged cycling exercise spares muscle glycogen but does not affect intramyocellular lipid use
Using contemporary stable-isotope methodology and fluorescence microscopy, we assessed the impact of carbohydrate supplementation on whole-body and fiber-type-specific intramyocellular triacylglycerol (IMTG) and glycogen use during prolonged endurance exercise. Ten endurance-trained male subjects were studied twice during 3 h of cycling at 63 ± 4% of maximal O2 uptake with either glucose ingestion (CHO trial; 0.7 g CHO kg−1 h−1) or without (CON placebo trial; water only). Continuous infusions with [U-13C] palmitate and [6,6-2H2] glucose were applied to quantify plasma free fatty acids (FFA) and glucose oxidation rates and to estimate intramyocellular lipid and glycogen use. Before and after exercise, muscle biopsy samples were taken to quantify fiber-type-specific IMTG and glycogen content. Plasma glucose rate of appearance (Ra) and carbohydrate oxidation rates were substantially greater in the CHO vs CON trial. Carbohydrate supplementation resulted in a lower muscle glycogen use during the first hour of exercise in the CHO vs CON trial, resulting in a 38 ± 19 and 57 ± 22% decreased utilization in type I and II muscle-fiber glycogen content, respectively. In the CHO trial, both plasma FFA Ra and subsequent plasma FFA concentrations were lower, resulting in a 34 ± 12% reduction in plasma FFA oxidation rates during exercise (P < 0.05). Carbohydrate intake did not augment IMTG utilization, as fluorescence microscopy revealed a 76 ± 21 and 78 ± 22% reduction in type I muscle-fiber lipid content in the CHO and CON trial, respectively. We conclude that carbohydrate supplementation during prolonged cycling exercise does not modulate IMTG use but spares muscle glycogen use during the initial stages of exercise in endurance-trained men
Scale-invariant magnetoresistance in a cuprate superconductor
The anomalous metallic state in high-temperature superconducting cuprates is
masked by the onset of superconductivity near a quantum critical point. Use of
high magnetic fields to suppress superconductivity has enabled a detailed study
of the ground state in these systems. Yet, the direct effect of strong magnetic
fields on the metallic behavior at low temperatures is poorly understood,
especially near critical doping, . Here we report a high-field
magnetoresistance study of thin films of \LSCO cuprates in close vicinity to
critical doping, . We find that the metallic state
exposed by suppressing superconductivity is characterized by a
magnetoresistance that is linear in magnetic field up to the highest measured
fields of T. The slope of the linear-in-field resistivity is
temperature-independent at very high fields. It mirrors the magnitude and
doping evolution of the linear-in-temperature resistivity that has been
ascribed to Planckian dissipation near a quantum critical point. This
establishes true scale-invariant conductivity as the signature of the strange
metal state in the high-temperature superconducting cuprates.Comment: 10 pages, 3 figure
Beyond small-scale transients: a closer look at the diffuse quiet solar corona
Within the quiet Sun corona imaged at 1 MK, much of the field of view
consists of diffuse emission that appears to lack the spatial structuring that
is so evident in coronal loops or bright points. We seek to determine if these
diffuse regions are categorically different in terms of their intensity
fluctuations and spatial configuration from the more well-studied dynamic
coronal features. We analyze a time series of observations from Solar Orbiter's
High Resolution Imager in the Extreme Ultraviolet to quantify the
characterization of the diffuse corona at high spatial and temporal
resolutions. We then compare this to the dynamic features within the field of
view, mainly a coronal bright point. We find that the diffuse corona lacks
visible structuring, such as small embedded loops, and that this is persistent
over the 25 min duration of the observation. The intensity fluctuations of the
diffuse corona, which are within +/-5%, are significantly smaller in comparison
to the coronal bright point. Yet, the total intensity observed in the diffuse
corona is of the same order as the bright point. It seems inconsistent with our
data that the diffuse corona is a composition of small loops or jets or that it
is driven by discrete small heating events that follow a power-law-like
distribution. We speculate that small-scale processes like MHD turbulence might
be energizing the diffuse regions, but at this point we cannot offer a
conclusive explanation for the nature of this feature.Comment: Accepted for publication in A&A. 10 pages, 8 figure
Internet of things platform for energy management in multi-microgrid system to improve neutral current compensation
© 2018 by the authors. In this paper, an Internet of Things (IoT) platform is proposed for Multi-Microgrid (MMG) system to improve unbalance compensation functionality employing three-phase four-leg (3P-4L) voltage source inverters (VSIs). The two level communication system connects the MMG system, implemented in Power System Computer Aided Design (PSCAD), to the cloud server. The local communication level utilizes Modbus Transmission Control Protocol/Internet Protocol (TCP/IP) and Message Queuing Telemetry Transport (MQTT) is used as the protocol for global communication level. A communication operation algorithm is developed to manage the communication operation under various communication failure scenarios. To test the communication system, it is implemented on an experimental testbed to investigate its functionality for MMG neutral current compensation (NCC). To compensate the neutral current in MMG, a dynamic NCC algorithm is proposed, which enables the MGs to further improve the NCC by sharing their data using the IoT platform. The performance of the control and communication system using dynamic NCC is compared with the fixed capacity NCC for unbalance compensation under different communication failure conditions. The impact of the communication system performance on the NCC sharing is the focus of this research. The results show that the proposed system provides better neutral current compensation and phase balancing in case of MMG operation by sharing the data effectively even if the communication system is failing partially
Pacific Northwest National Laboratory Site Environmental Report for Calendar Year 2011
The PNNL Site Environmental Report for Calendar Year 2011 was prepared pursuant to the requirements of Department of Energy (DOE) Order 231.1B, "Environment, Safety and Health Reporting" to provide a synopsis of calendar year 2011 information related to environmental management performance and compliance efforts. It summarizes site compliance with federal, state, and local environmental laws, regulations, policies, directives, permits, and orders and environmental management performance
Summary of TPH Monitoring Conducted at 100-NR-2- 2008 through 2010
A summary of TPH monitoring conducted along the 100-N shoreline and the 100-NR-2 operable uni
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