Distribution of SF-36 vitality scores, according to gender.

<p>Higher vitality scores indicate less fatigue.</p

Baseline characteristics of the 1080 participants.

<p>Baseline characteristics of the 1080 participants.</p

Multivariate analyses showing independent predictors of survival, according to the method of dealing with missing SF-36 data.

<p>LACS = lacunar syndrome, PACS = partial anterior circulation syndrome, TACS = total anterior circulation syndrome, POCS = posterior circulation syndrome</p><p>Note that hazard ratios and 95% CI for SF-36 vitality are provided for all four models, even though the hazard ratio reached statistical significance in only two of the models.</p

Relationship between SF-36 mental health and vitality.

<p>Higher scores indicate better health status. As the number of data points are limited, a small random component (‘jitter’) has been added to each variable to better demonstrate the number of patients at a single co-ordinate. (Pearson correlation coefficient 0.20, p<0.001, n = 1004).</p

Exploratory analysis of outcome data.

<p>Exploratory analysis of outcome data.</p

CONSORT flow chart for the GaPP1 trial.

<p>DNA = women who did not attend for screening.</p

Cost-effectiveness plane.

<p>Cost-effectiveness plane.</p

Cost-effectiveness acceptability curve.

<p>Cost-effectiveness acceptability curve.</p

Adverse events.

<p>Number of participants with at least one adverse event, and severity of the worst event per participant.</p

Relationship between oestradiol concentration, and volumetric and vascular changes.

<p>(a) shows median uterine volume change, assessed by T2-weighted MRI; error bars show the interquartile range. Data are shown for treated participants (groups 1 and 2), classified as oestradiol-suppressed and -unsuppressed as described in the text. (b) shows changes in uterine volume and fibroid <i>k</i>_ep (DCE-MRI) for all patients (group 1: black, group 2: red, group 3: blue) at the final MRI scan. The areas of the data points are proportional to blood oestradiol concentration at the same time point (the largest data point corresponds to a value of 1153 pg/mL).</p