Expression of Fibronectin and Tenascin after Direct Capping of the Pulp with Mineral Trioxide Aggregate and Biodentine®

BACKGROUND: Caries is a destructive process leading to progressive demineralization of the inorganic part of the tooth, accompanied by enzyme disintegration of the organic component of the tooth tissue. Considering the fact that caries activity can be stopped if the demineralization process is stopped, it is clear that the objectives of caries treatment are focused toward elimination of etiological factors and stimulation of regeneration of the dental tissues. That is why in the last years treatment of the caries disease is targeted to remineralization of the initial carious lesions, as well as on the biological behavior of the pulp-dentine complex after application of certain medications. AIM: The aim of this study is to evaluate impact of the two materials for direct capping, mineral trioxide aggregate (MTA) and Biodentine®, on the expression of glycoproteins fibronectin (FN), and tenascin (TN), responsible for dentinogenesis. METHODS: In the tests were used materials MTA and Biodentine, as agents for direct capping of pulp exposure. From 60 extracted teeth included in this in vitro study, tissue cuts were made. Each of them was then analyzed on a light microscope to determine the amount of two extracellular matrix glycoproteins, FN-C, and TN-C. RESULTS: Our study show that there is an expressed immunoreactivity for FN and for TN in the fibronectin bridge under MTA and Biodentine® after 8, and even after 30 days of their application. CONCLUSION: Based on this study, we can conclude that both materials – MTA and Biodentine – may induce reparative dentinogenesis, in which FN and TN have certainly a major role in the formation of the fibronectin matrix

LIVER TUMOR (LYMPANGIOMA CAPILLARE HEPATIS) – A RARITY IN NEONATAL PRACTICE

Fetal tumors are rare in the neonatal age. They are characterized by various pathohistological findings. The paper presents the case of a male newborn, aged four days, with a liver tumor (lymphangioma capillare hepatis). The outcome was good thanks to a multidisciplinary approach

PROCESS MINING IN THE MANUFACTURING CONTEXT: REVIEW AND RECOMMENDATIONS

Modern manufacturing systems generate large amounts of data regarding the automation of business processes, which can be analyzed with process mining techniques. However, there is not enough consolidation on process mining methodologies or guidelines on properly applying numerous techniques in particular manufacturing scenarios. This paper aims to synthesize data on process mining projects' goals, utilize information systems, analyze business processes, and apply process mining types, software tools, and algorithms applied in the manufacturing industry. The data on the key research elements are gathered through a systematic literature review and analyzed with descriptive statistics and crosstabs analysis in SPSS. The research results enable process mining practitioners, business analysts, and business managers to gain insight into the trends and benefits of process mining application in the manufacturing context, as well as a guideline on how process mining techniques can be applied depending on the analyzed business process and process mining projects' goal

Learning Environment Digital Transformation: Systematic Literature Review

We are witnessing how digital technologies can be used to transform everyday life – launch new or grow incumbent companies, change teaching and learning environment, and research. The latest literature research has overwhelmingly positively assessed the use of digital technologies in higher education, indicating certain challenges in this regard. In the modern era, higher education institutions need to evolve steadily, following the digital transformation. Overall, the emphasis is on the encouragement and promotion of digital technology in the learning process. However, a small number of research papers addressed the learning environment’s digital transformation in the past decade. With the aim of contributing to a relevant topic, this paper presents a systematic literature review of related articles published on learning environment digital transformation in ten years. Accordingly, significant and eminent results are discussed, together with guidelines for future research.info:eu-repo/semantics/publishedVersio