40 research outputs found
Pouzdanost kompjuterizovanih kefalometrijskih predviÄanja rezultata hirurÅ”ke korekcije mandibularnog prognatizma
Introduction. A successful treatment outcome in dentofacial deformity patients commonly requires combined orthodontic-surgical therapy. This enables us to overcome functional, aesthetic and psychological problems. Since most patients state aesthetics as the primary motive for seeking therapy, cephalometric predictions of treatment outcome have become the essential part of treatment planning, especially in combined orthodontic-surgical cases. Objective. The aim of this study was to evaluate the validity and reliability of computerized orthognathic surgery outcome predictions generated using the Nemotec Dental Studio NX 2005 software. Methods. The sample of the study consisted of 31 patients diagnosed with mandibular prognathism who were surgically treated at the Hospital for Maxillofacial Surgery in Belgrade. Investigation was done on lateral cephalograms made before and after surgical treatment. Cephalograms were digitized and analyzed using computer software. According to measurements made on superimposed pre- and postsurgical cephalograms, the patients were retreated within the software and the predictions were assessed by measuring seven angular and three linear parameters. Prediction measurements were then compared with the actual outcome. Results. Results showed statistically significant changes between posttreatment and predicted values for parameters referring to lower lip and mentolabial sulcus position. Conclusion. Computerized cephalometric predictions for hard-tissue structures in the sagittal and vertical planes, as well as the VTO parameters, generated using the Nemotec Dental Studio NX 2005 software are reliable, while lower lip and mentolabial sulcus position predictions are not reliable enough.Uvod. Radi postizanja Å”to boljih krajnjih rezultata, osobe sa dentofacijalnim deformitetima najÄeÅ”Äe se leÄe kombinovanom ortodontsko-hirurÅ”kom terapijom. Na taj naÄin reÅ”avaju se funkcionalni, estetski i psiholoÅ”ki problemi. Kako najveÄi broj pacijenata navodi estetsku promenu kao primarni motiv leÄenja, kefalometrijsko predviÄanje ishoda je važan deo planiranja terapije, posebno kod složenih sluÄajeva. Cilj rada. Cilj rada je bio da se proceni preciznost i pouzdanost predviÄanja ishoda hirurÅ”ke korekcije mandibularnog prognatizma razvijenih u okviru kompjuterskog softvera Nemotec Dental Studio NX 2005. Metode rada. Ispitan je 31 pacijent s mandibularnim prognatizmom koji je operisan na Klinici za maksilofacijalnu hirurgiju StomatoloÅ”kog fakulteta Univerziteta u Beogradu. Istraživanje je izvedeno na profilnim teleradiogramima snimljenim pre i posle hirurÅ”ke intervencije. Nakon digitalizacije snimaka izvrÅ”ena je kompjuterizovana kefalometrijska analiza. Na osnovu merenja odreÄenih horizontalnih i vertikalnih rastojanja na preoperacionim i postoperacionim radiogramima, uraÄena je simulacija hirurÅ”kih korekcija i na njima izmerena vrednost sedam angularnih parametara i tri linearna parametra, Äija je vrednost uporeÄena s vrednostima na postoperacionim radiogramima. Rezultati. Ustanovljene su statistiÄki znaÄajne razlike izmeÄu postoperacionih i predviÄenih vrednosti za parametre koji govore o položaju donje usne i mentolabijalnog sulkusa. ZakljuÄak. Kompjuterizovana kefalometrijska predviÄanja položaja Ävrstotkivnih struktura u sagitalnoj i vertikalnoj ravni, kao i VTO parametara, dobijena u okviru koriÅ”Äenog programa su pouzdana, dok su predviÄanja položaja donje usne i mentolabijalnog sulkusa nedovoljno pouzdana
Potential, regional distribution and the cost of delivered biomass at the power plant location: A case study of the Republic of Serbia
Terapijski efekti tri vrste funkcionalnih aparata u leÄenju malokluzija II skeletne klase - sagitalne i vertikalne promene
Introduction/Objective Class II malocclusions are sagittal malocclusions characterized by a distal relationship of posterior teeth. Depending on the underlying problem, Class II malocclusions can be skeletal or dentoalveolar. Class II malocclusion treatment modality will depend on the cause, severity, and age. Growth modification is the best treatment option in growing patients with skeletal Class II malocclusions. The aim of this study was to establish and compare sagittal and vertical skeletal and dental changes in patients treated with the 'M block' appliance, the Frankel functional regulator, and the Balters' bionator. Methods The sample consisted of 70 patients diagnosed with skeletal Class II malocclusions (ANB > 4Ā°) and mandibular retrognathism (SNB lt 80Ā°). The patients were divided into three groups according to the type of appliance. All the patients went through the standard diagnostic procedure (anamnesis, clinical and functional analysis, study model, panoramic radiograph, and cephalometric analysis), and dental and skeletal age was determined. Treatment effects were analyzed on study models and cephalograms at the end of treatment. Results All the appliances led to significant mandibular anterior movement and sagittal growth, which reduced the ANB values. All three groups of patients presented with neutral growth pattern, upper incisor retrusion, and lower incisor protrusion at the end of treatment. Conclusion The results of this study indicate efficacy of all three appliances in skeletal Class II malocclusion treatment.Uvod/Cilj rada Malokluzije II klase su sagitalne nepravilnosti zagrižaja koje karakteriÅ”e distalni odnos boÄnih zuba. U zavisnosti od toga koje strukture su u nepravilnom odnosu, dele se na skeletne i dentoalveolarne. Terapija II klase zavisi od uzroka, izraženosti i uzrasta. Najbolji vid terapije ukoliko pacijenti i dalje rastu je modifikacija rasta. Cilj ove studije bio je da se utvrde i uporede sagitalne i vertikalne promene na skeletnim i dentalnim strukturama u toku leÄenja M blok-aparatom, Frenklovim regulatorom funkcije tip I i bionatorom po Baltersu tip I. Metode Sedamdeset ispitanika sa dijagnozom skeletnog distalnog zagrižaja (ANB > 4Ā°) i mandibularnog retrognatizma (SNB lt 80Ā°), prema vrsti aparata, podeljeni su u tri grupe. Svi su proÅ”li kroz standardnu dijagnostiku (anamneza, kliniÄka i funkcionalna analiza, analiza studijskih modela, ortopantomografskog i profilnog telerendgenskog snimka). Terapijski efekti i promene analizirani su na studijskim modelima i profilnom snimcima po zavrÅ”etku terapije. Rezultati Sva tri aparata dovela su do znaÄajnog mezijalnog usmeravanja i sagitalnog rasta mandibule, Å”to je smanjilo ANB ugao. U sve tri grupe je utvrÄen neutralni rast, kao i retruzija gornjih i protruzija donjih sekutiÄa. ZakljuÄak Rezultati studije ukazuju na efikasnost sva tri ispitivana aparata u leÄenju skeletnih malokluzija II klase
Hyperbaric oxygenation in prevention of amputations of diabetic foot
Background/Aim. Diabetic foot is the term for the pathological changes on foot in patients with diabetes. It is caused by diabetic angiopathy, polyneuropathy and osteoarthropathy. The treatment is complex and long-term and often leads to the loss of the extremity. The appliance of hyperbaric oxygen therapy (HBOT) has a lot more important place in adjuvant treatment of this disease. The aim of this study was to determine the influence of HBOT on the wound healing in comparison with the conventional treatment, the possibility of shortening the time of the treatment in patients with diabetic foot. Methods. In a five-year period a retrospective-prospective multicentric study, involving 60 patients with diabetic foot divided into two groups, was performed. The first group (group A) consisted of 30 patients treated by combined therapy (with medications, surgical therapy and HBOT). All the patients were receiving HBOT in the Special Hospital for Hyperbaric Medicine, CHM Hollywell-Neopren in Belgrade. The control group (group B) also consisted of 30 patients treated with medications and surgical therapy, but without HBOT. Results. The demographic data, the types of diabetes, as well as the Wagner classification stage of diabetic ulcers and radiography scans of changes in bones were equal in both groups. The median healing time of the Wagner grade III ulcer in the group A was 37.36 days [mean +/- standard deviation (SD) = 65.6 +/- 45.8 days], and in the group B 99.78 days (mean +/- SD = 134.8 +/- 105.96 days) and it was statistically significant (p = 0.074). The median time of recovery in patients of the group A with the Wagner grade IV was 48.18 days (mean +/- SD = 49.7 +/- 33.8 days), and in the group B 85.05 days (mean +/- SD = 86.7 +/- 71.6 days) and that was statistically significant (p = 0.121). The foot amputations were performed in both groups in 3 (10%) patients. In the group A there were no high amputations, whereas in the group B there were 4 (13.33%) below-knee amputations and 4 (13.33%) above-knee amputations which was highly statistically significant (p lt 0.0001). Conclusion. In this study, HBOT definitely showed positive adjuvant role in the treatment of diabetic foot. For the good treatment result it is essential the timely and successful surgical treatment of the ulcer and the use of bandage with the healing dressings. In case of the clear signs of local infection, the antibiotic therapy according to the antibiogram is necessary
Hipodoncija i mutacija WNT10A gena - prikaz sluÄaja
Tooth agenesis is common dentofacial malformation in humans. Its etiology is still not clear. Hypodontia has been regarded as a multifactorial condition influenced by gene function, environmental interaction and developmental timing. More than 300 genes have been related with patterning, morphogenesis and cell differentiation in teeth. According to data WNT10A gene is considered to have an important role in odontogonesis. The aim of this study was to show mutation status in WNT10A gene in a family with two members with diagnosis of hypodontia/oligodontia. In the reported family (father, mother, son, daughter) children were diagnosed with congenital tooth agenesis (son-2 teeth, daughter-11 teeth), while parents negated congenital absence of teeth. We identified a heterozygous missense mutation, c.682T>A (p.Phe228Ile) within the exon 3 of WNT10A in mother and father and the same homozygous mutation was detected in the same region of WNT10A gene in daughter and son. Observed differences in our study, from no symptoms to mild/severe hypodontia, could be the consequence of genetic influence of c.682T>A(p.Phe228Ile) mutation, but also the contribution of many environmental factors during odontogenesis.UroÄeni nedostatak zuba predstavlja jednu od najÄeÅ”Äih dentofacijalnih anomalija kod Äoveka. Etiologija hipodoncije i dalje nije potpuno definisana i smatra se da su za njenu etiologiju odgovorni brojni genetski i sredinski faktori koji deluju u razliÄitim fazama razvoja zuba. Preko 300 gena povezuje se sa morfogenezom i Äelijskom diferencijacijom u toku razvoja zuba, a prema podacima WNT10A gen je jedan od gena koji ima veoma bitnu ulogu u kontroli odontogeneze. Cilj ovog rada bio je da se prikaže mutacioni status WNT10A gena u porodici sa dijagnostikovanom hipodoncijom/oligodoncijom. U prikazanoj porodici (otac, majka, sin i Äerka) kod dva Älana dijagnostikovan je uroÄeni nedostatak zuba (sin - dva zuba, Äerka - 11 zuba), dok kod roditelja ovaj nedostatak nije zabeležen. Kod svih Älanova porodice, u okviru egzona 3 WNT10A gena detektovana je mutacija c.682T>A (p.Phe228Ile). Kod majke i oca ova 'missense' mutacija je bila u heterozigotnom obliku, dok je kod sina i Äerke utvrÄeno prisustvo iste mutacije u homozigotnom obliku. Zabeležene razlike u analiziranoj porodici, od odsustva simptoma do blage hipodoncije i izrazite oligodoncije, mogu biti posledica prisustva c.682T>A (p.Phe228Ile) mutacije, ali takoÄe i uticaja faktora sredine u toku odontogeneze
Direct correlation between compression stockings and venotonics (Diosmins) and flow vein diseases in stomatology students
Diseases of veins are considered one of the most common diseases of modern man, right after caries of teeth. Those diseases usually come to exist as a result of genetic and/or other pre-dispositioning factors, however, in most cases, those factors can be effectively tamed through preventive and therapeutic methods. Two studies were carried out on randomly selected third and fourth year stomatology college students. In the first study, we solely focused on the effects of monotherapy compression stockings. The second study was a continuation of the first and the respondents were asked to take venotonic Diosmin (Detralex 1000 mg) in addition to wearing compression stockings. In the group of 30 patients, 49% had positive family history of the disease, and in total, 70% showed signs of discomfort and diseases related to venous system. Ten respondents who showed major problems or pathological changes, were given custom made Sigvaris graduated compression stockings, which they wore for eight weeks. Final results of the first study showed that the feeling of heaviness in the legs reduced in 55.55% of respondents, while 66.66% patients recorded reduced pain in legs when standing for a long time. Issues of swelling of the bottom of the feet and lower legs disappeared for all patients. In the second study, which included adding a dose of Diosmin in addition to compression stockings, 66.66% of the patients saw signs of heaviness feeling in the legs improve, 77.77% recorded that pain in the legs when standing for a long time decreased and 100% of patients saw swelling of the bottom of the feet and lower legs disappear. This eight week study was too short to show significant signs of improvement in varicose, however, we expect that in six months, patients will begin to show signs of improvement in varicose altered veins. When comparing the results of the first and second study, we concluded that the three-month combination therapy of compression stockings and Diosmin yielded 12.5% better results of reduction of the following symptoms: feeling of heaviness in the legs, pain in the legs when standing for a long time, then when just using the compression socks (study 1).Oboljenja vena spadaju u najuÄestalije bolesti savremenog Äoveka,odmah posle kariesa zuba. Na njihov nastanak utiÄu nasledni i steÄeni faktori. SteÄeni fatori rizika najÄeÅ”Äe su okidaÄ za aktiviranje naslednih faltora (predispozicije) na koje se može efikasno delovati, kako preventivno tako i terapijski. U HirurÅ”koj klinici KBC Zvezdara, nastavnoj bazi StomatoloÅ”kog fakulteta Univerziteta u Beogradu, sprovedene su dve studije na studentima IV i V godine sluÄajnim izborom ispitanika. U prvoj studiji su opservirani efekti monoterapije kompresivnim Äarapama na tok oboljenja vena, druga studija je nastavak prve i ispitanici su pored kompresivnih Äarapa uzimali i venotonik Diosmin (Detralex 1000 mg). U grupi od 30 ispitanika znake oboljenja vezane za venski sistem pokazalo je 70% ispitanika, a pozitivnu porodiÄnu anamnezu je imalo 49% ispitanika. Deset ispitanika je imalo znaÄajne tegobe ili patoloÅ”ke promene koje su zahtevale neku terapiju i dobili su graduisane kompresivne Äarape po meri firme Sigvaris, koje su nosili 8 nedelja. ZavrÅ”ni rezultati prve studije pokazali su da je poboljÅ”anje oseÄaja težine u nogama osetilo 55,55% ispitanika, smanjenje bolova u nogama pri dužem stajanju zabeleženo je kod 66,66% ispitanika, otoke stopala i potkolenica nije imao viÅ”e nijedan ispitanik (smanjenje tegoba 100%) U drugoj studiji, u kojoj je pored kompresivnih Äarapa bio ukljuÄen i venotonik nakon osam nedeljne primene kombinovane terapije poboljÅ”anje simptoma oseÄaja težine u nogama osetilo je 66,66% ispitanika, bolove kod dužeg stajanja 77,77%, dok se i u ovoj studiji pokazalo da otoke stopala i potkolenica na kraju studije nije imao nijedan ispitanik (100% poboljÅ”anje). Za povlaÄenje varikoziteta je studija bila suviÅ”e kratka ali posle 6 meci je za oÄekivati i poboljÅ”anje stanja varikozno izmenjenih vena. Komparacijom rezultata prve i druge studije doÅ”li smo do zakljuÄka da je tromeseÄna kombinovana terapija kompresivnim Äarapama i venotonikom dala bolje rezultate za 12,5% u smanjenju simptoma oseÄaja težine u nogama i bolova u nogama pri dužem stajanju u odnosu na monoterapiju samo kompresivnim sredstvima
Terapija malokluzija III klase u ranoj meÅ”ovitoj denticiji - prikaz dva sluÄaja
Class III malocclusion is orthodontic anomaly where mandibular arch is in mesial position to maxillary arch. Reasons for Class III malocclusion can be found in mandibular prognathism, maxillar retrognathism or combination of these two. In most cases of mandibular prognathism, it is necessary to postpone the treatment until the growth ceases. However, if certain conditions are accomplished it is possible to start early treatment of class III malocclusion to improve occlusal relations and provide more favorable environment for future growth. The aim of this study was to present treatment of two patients with Class III maloclussion in early mixed dentition, using two different appliances: Delaire mask and Frankel functional regulator type 3. The treatment with Delaire mask resulted in rotation of maxilla downward and forward due to the angle of extraoral part of the mask to the occlusal plane that was modified to be almost 45Ā°. At the end of the treatment facial esthetics was significantly improved. Moving maxilla forward resulted in straight profile, whereas moving maxilla downward lead to coordination of upper, middle and lower facial third. The result of the treatment in patient who used Frankel functional regulator was correction of anterior crossbite by premaxilla development and incisors protrusion. Significant differences in SNA, SNB and ANB angle values at the beginning and at the end of the treatment were not found suggesting that most changes were dental but not skeletal.Skeletna malokluzija III klase je nesklad u meÄusobnom odnosu gornje i donje vilice, jer je donja vilica postavljena mezijalnije u odnosu na gornju. Uzrok nastanka skeletne malokluzije III klase može biti mandibularni prognatizam, maksilarni retrognatizam ili kombinacija ova dva uzroka. U sluÄaju isuviÅ”e razvijene donje vilice najÄeÅ”Äe je potrebno saÄekati zavrÅ”etak rasta, kako bi se primenilo konaÄno leÄenje. MeÄutim, ako su ispunjeni odreÄeni uslovi, moguÄe je primeniti ranu terapiju III klase, da bi se poboljÅ”ali okluzalni odnosi i obezbedila dobra osnova za dalji rast. Cilj ovog rada bio je da se prikaže terapijski efekat dva sluÄaja malokluzije III klase u ranom uzrastu pomoÄu razliÄitih ortodontskih aparata: Delerove maske i Frenklovog regulatora funkcije tip 3. Kod pacijentkinje koja je tokom leÄenja nosila Delerovu masku gornja vilica je zarotirana unapred i nadole, jer je ugao delovanja sile modifikovan da bude skoro 45 stepeni. Na kraju leÄenja postignut je znatno bolji izgled lica. Pomeranjem gornje vilice unapred postignut je prav profil, dok je pomeranje nadole dovelo do usklaÄivanja visine srednje treÄine lica sa gornjom i donjom. Kod pacijenta kod kojeg je tokom leÄenja primenjena terapija Frenklovim regulatorom funkcije tip 3 do korekcije obrnutog preklopa sekutiÄa doÅ”lo je kombinacijom razvijanja premaksile i protruzije sekutiÄa. ZnaÄajne promene u vrednostima uglova SNA, SNB i ANB nisu zabeležene na kraju terapije u odnosu na poÄetak, Å”to bi ukazivalo na to da su postignute promene uglavnom dentalne, a ne skeletne
The treatment of class III malocclusion in early mixed dentition: Two case reports
Class III malocclusion is orthodontic anomaly where mandibular arch is in mesial position to maxillary arch. Reasons for Class III malocclusion can be found in mandibular prognathism, maxillar retrognathism or combination of these two. In most cases of mandibular prognathism, it is necessary to postpone the treatment until the growth ceases. However, if certain conditions are accomplished it is possible to start early treatment of class III malocclusion to improve occlusal relations and provide more favorable environment for future growth. The aim of this study was to present treatment of two patients with Class III maloclussion in early mixed dentition, using two different appliances: Delaire mask and Frankel functional regulator type 3. The treatment with Delaire mask resulted in rotation of maxilla downward and forward due to the angle of extraoral part of the mask to the occlusal plane that was modified to be almost 45Ā°. At the end of the treatment facial esthetics was significantly improved. Moving maxilla forward resulted in straight profile, whereas moving maxilla downward lead to coordination of upper, middle and lower facial third. The result of the treatment in patient who used Frankel functional regulator was correction of anterior crossbite by premaxilla development and incisors protrusion. Significant differences in SNA, SNB and ANB angle values at the beginning and at the end of the treatment were not found suggesting that most changes were dental but not skeletal
Uticaj graduisanih kompresivnih Äarapa i venotonika (diosmina) na tok oboljenja vena kod studenata stomatologije
Diseases of veins are considered one of the most common diseases of modern man, right after caries of teeth. Those diseases usually come to exist as a result of genetic and/or other pre-dispositioning factors, however, in most cases, those factors can be effectively tamed through preventive and therapeutic methods. Two studies were carried out on randomly selected third and fourth year stomatology college students. In the first study, we solely focused on the effects of monotherapy compression stockings. The second study was a continuation of the first and the respondents were asked to take venotonic Diosmin (Detralex 1000 mg) in addition to wearing compression stockings. In the group of 30 patients, 49% had positive family history of the disease, and in total, 70% showed signs of discomfort and diseases related to venous system. Ten respondents who showed major problems or pathological changes, were given custom made Sigvaris graduated compression stockings, which they wore for eight weeks. Final results of the first study showed that the feeling of heaviness in the legs reduced in 55.55% of respondents, while 66.66% patients recorded reduced pain in legs when standing for a long time. Issues of swelling of the bottom of the feet and lower legs disappeared for all patients. In the second study, which included adding a dose of Diosmin in addition to compression stockings, 66.66% of the patients saw signs of heaviness feeling in the legs improve, 77.77% recorded that pain in the legs when standing for a long time decreased and 100% of patients saw swelling of the bottom of the feet and lower legs disappear. This eight week study was too short to show significant signs of improvement in varicose, however, we expect that in six months, patients will begin to show signs of improvement in varicose altered veins. When comparing the results of the first and second study, we concluded that the three-month combination therapy of compression stockings and Diosmin yielded 12.5% better results of reduction of the following symptoms: feeling of heaviness in the legs, pain in the legs when standing for a long time, then when just using the compression socks (study 1).Oboljenja vena spadaju u najuÄestalije bolesti savremenog Äoveka,odmah posle kariesa zuba. Na njihov nastanak utiÄu nasledni i steÄeni faktori. SteÄeni fatori rizika najÄeÅ”Äe su okidaÄ za aktiviranje naslednih faltora (predispozicije) na koje se može efikasno delovati, kako preventivno tako i terapijski. U HirurÅ”koj klinici KBC Zvezdara, nastavnoj bazi StomatoloÅ”kog fakulteta Univerziteta u Beogradu, sprovedene su dve studije na studentima IV i V godine sluÄajnim izborom ispitanika. U prvoj studiji su opservirani efekti monoterapije kompresivnim Äarapama na tok oboljenja vena, druga studija je nastavak prve i ispitanici su pored kompresivnih Äarapa uzimali i venotonik Diosmin (Detralex 1000 mg). U grupi od 30 ispitanika znake oboljenja vezane za venski sistem pokazalo je 70% ispitanika, a pozitivnu porodiÄnu anamnezu je imalo 49% ispitanika. Deset ispitanika je imalo znaÄajne tegobe ili patoloÅ”ke promene koje su zahtevale neku terapiju i dobili su graduisane kompresivne Äarape po meri firme Sigvaris, koje su nosli 8 nedelja. ZavrÅ”ni rezultati prve studije pokazali su da je poboljÅ”anje oseÄaja težine u nogama osetilo 55,55% ispitanika, smanjenje bolova u nogama pri dužem stajanju zabeleženo je kod 66,66% ispitanika, otoke stopala i potkolenica nije imao viÅ”e nijedan ispitanik (smanjenje tegoba 100%) U drugoj studiji, u kojoj je pored kompresivnih Äarapa bio ukljuÄen i venotonik nakon osam nedeljne primene kombinovane terapije poboljÅ”anje simptoma oseÄaja težine u nogama osetilo je 66,66% ispitanika, bolove kod dužeg stajanja 77,77%, dok se i u ovoj studiji pokazalo da otoke stopala i potkolenica na kraju studije nije imao nijedan ispitanik (100% poboljÅ”anje). Za povlaÄenje varikoziteta je studija bila suviÅ”e kratka ali posle 6 meci je za oÄekivati i poboljÅ”anje stanja varikozno izmenjenih vena. Komparacijom rezultata prve i druge studije dosli smo do zakljuÄka da je tromeseÄna kombinovana terapija kompresivnim Äarapama i venotonikom dala bolje rezultate za 12,5% u smanjenju simptoma oseÄaja težine u nogama i bolova u nogama pri dužem stajanju u odnosu na monoterapiju samo kompresivnim sredstvima
ODGOÄENA MANIFESTACIJA MIOKARDITISA NAKON COVID-A
: Myocardial involvement of coronavirus disease 2019 (COVID-19) varies and is considered to be more serious in patients with severe COVID-19 clinical presentation. Although myocarditis is usually recognized in the setting of acute SARS-CoV-2 infection, delayed manifestations are recognized as well. Case report. A 51-year-old male patient was admitted due to the clinical signs of congestive heart failure, two months after moderate clinical expression of COVID-19 pneumonia, treated as an outpatient. Transthoracic echocardiography (TTE) revealed dilated cardiomyopathy with the presence of diffuse left ventricular (LV) hypokinesia, severely reduced ejection fraction (EF 18%) and diastolic dysfunction with increased left atrial filling pressure. Baseline laboratory tests revealed elevated hs-troponin I, NT-proBN. Diagnostic workout excluded coronary artery disease. Cardiac magnetic resonance imaging strongly pointed in the direction of unrecognized post-COVID myocarditis. The patient was treated according to current guidelines for heart failure with reduced EF. Eight months after discharge, the patient had no limitations of physical activity and TTE showed significant improvement in the systolic function of the left ventricle, EF was 47%, with normal LV filling pressure. Conclusion: Myocarditis is not an infrequent manifestation of COVID-19 infection, especially in hospitalized patients with severe clinical presentation, and commonly manifests within the first week after initial symptoms. Our case report represents an example that also patients with mild form of COVID-19 treated as outpatients can have delayed onset of heart failure as a consequence of COVID-19-induced myocarditis. Therefore, COVID-19 patients deserve a comprehensive approach with systematic clinical and echocardiographic follow-up in order to establish a timely diagnosis, provide appropriate treatment, and prevent serious complications.ZahvaÄenost miokarda koronavirusnom boleÅ”Äu 2019 (COVID-19) varira i smatra se ozbiljnijom u bolesnika s teÅ”kom kliniÄkom slikom COVID-19. Iako se miokarditis obiÄno prepoznaje u okruženju akutne infekcije SARS-CoV-2, prepoznaju se i odgoÄene manifestacije. Prikaz sluÄaja: Bolesnik u dobi od 51 godine primljen je zbog kliniÄkih znakova kongestivnog zatajenja srca dva mjeseca nakon umjerene kliniÄke manifestacije pneumonije COVID-19, lijeÄen ambulantno. Transtorakalna ehokardiografija (TTE) otkrila je dilatiranu kardiomiopatiju s prisutnoÅ”Äu difuzne hipokinezije lijevog ventrikla (LV), ozbiljno smanjenu ejekcijsku frakciju (18%) i dijastoliÄku disfunkciju s poveÄanim osjeÄajem tlaka u lijevom atriju. Osnovni laboratorijski testovi otkrili su poviÅ”en hs-troponin I, NT-proBN. DijagnostiÄka vježba iskljuÄila je koronarnu bolest. Magnetska rezonancija srca snažno je pokazala u smjeru neprepoznatog miokarditisa nakon COVID-a. Bolesnik je lijeÄen prema važeÄim smjernicama za zatajenje srca sa smanjenom ejekcijskom frakcijom. Osam mjeseci nakon otpusta bolesnik nije imao ograniÄenja tjelesne aktivnosti, a TTE je pokazao znaÄajno poboljÅ”anje sistoliÄke funkcije lijeve klijetke, ejekcijska frakcija je iznosila 47%, uz normalan tlak punjenja LV. ZakljuÄak. Miokarditis nije rijetka manifestacija infekcije COVID-19, osobito u hospitaliziranih pacijenata s teÅ”kom kliniÄkom slikom, i obiÄno se manifestira unutar prvog tjedna nakon poÄetnih simptoma. NaÅ” prikaz bolesnika je primjer da i pacijenti s blagim oblikom COVID-19 koji se lijeÄe ambulantno mogu imati odgoÄeni poÄetak zatajenja srca kao posljedicu miokarditisa izazvanog COVID-19. Stoga bolesnici s COVID-19 zaslužuju cjelovit pristup uz sustavno kliniÄko i ehokardiografsko praÄenje kako bi se pravodobno postavila dijagnoza, omoguÄilo odgovarajuÄe lijeÄenje i sprijeÄile ozbiljne
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