102 research outputs found

    Mining von BPMN-Prozessartefakten auf GitHub

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    Die Validierung von Programmanalysen und Analysewerkzeugen erfolgt häufig anhand einer Sammlung von Beispielprogrammen. Für eine aussagekräftige Bewertung sollte diese Sammlung repräsentativ sein. Gerade im Bereich der Analysen für domänenspezifische Sprachen wird zu diesem Zweck aber oft nur auf Fallstudien oder gar einzelne künstliche Programmbeispiele zurückgegriffen. In diesem Beitrag zeigen wir für die domänenspezifische Sprache BPMN, wie durch systematisches Mining auf GitHub.com ein Corpus von BPMN-Prozessen für die Validierung von Analysewerkzeugen generiert werden kann

    Relationship Between Flowability And Tank Closure Grout Quality

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    After completion of waste removal and chemical cleaning operations, Tanks 5-F and 6-F await final closure. The project will proceed with completing operational closure by stabilizing the tanks with grout. Savannah River Remediation's (SRR) experience with grouting Tanks 18-F and 19-F showed that slump-flow values were correlated with flow/spread inside these tanks. Less mounding was observed when using grouts with higher slump-flow. Therefore, SRNL was requested to evaluate the relationship between flowability and cured properties to determine whether the slump-flow maximum spread of Mix LP#8-16 could be increased from 28 inches to 30 inches without impacting the grout quality. A request was also made to evaluate increasing the drop height from 5 feet to 10 feet with the objective of enhancing the flow inside the tank by imparting more kinetic energy to the placement. Based on a review of the grout property data for Mix LP#8-16 collected from Tank 18-F and 19-F quality control samples, the upper limit for slump-flow measured per ASTM C 1611 can be increased from 28 to 30 inches without affecting grout quality. However, testing should be performed prior to increasing the drop height from 5 to 10 feet or observations should be made during initial filling operations to determine whether segregation occurs as a function of drop heights between 5 and 10 feet. Segregation will negatively impact grout quality. Additionally, increasing the delivery rate of grout into Tanks 5-F and 6-F by using a higher capacity concrete/grout pump will result in better grout spread/flow inside the tanks

    Thermal and nuclear design review of the NRX-A5 Reactor

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    A thermal and nuclear NRX-A5 Design Review was held at WANL on April 10, 1964. Analyses and planning performed to date on the NRX-A5 and subsequent reactors were presented. Systems analyses were performed on various "cooled periphery".and "hot periphery" seal configurations. A number of inner reflector designs were examined, as well as means for cooling the lateral support springs. Core component redesign incl,uded methods for controlling inter-element pressure distribution by undercutting or chamfering of fuel elements. Changes in tie rod diameters, use of as-extruded fuel elements, and performance analysis of the various systems were also described. Nuclear analysis was confined to parametric studies on excess reactivity and control drum span for inner reflector material combinations of graphite, aluminum, and/or beryllium. Changes required to more precisely define the NRX-A5 were discussed together with the effects associated with the twice power reactor capability envisioned for subsequent reactors

    Epigenetic Alterations Are Critical for Fear Memory Consolidation and Synaptic Plasticity in the Lateral Amygdala

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    Epigenetic mechanisms, including histone acetylation and DNA methylation, have been widely implicated in hippocampal-dependent learning paradigms. Here, we have examined the role of epigenetic alterations in amygdala-dependent auditory Pavlovian fear conditioning and associated synaptic plasticity in the lateral nucleus of the amygdala (LA) in the rat. Using Western blotting, we first show that auditory fear conditioning is associated with an increase in histone H3 acetylation and DNMT3A expression in the LA, and that training-related alterations in histone acetylation and DNMT3A expression in the LA are downstream of ERK/MAPK signaling. Next, we show that intra-LA infusion of the histone deacetylase (HDAC) inhibitor TSA increases H3 acetylation and enhances fear memory consolidation; that is, long-term memory (LTM) is enhanced, while short-term memory (STM) is unaffected. Conversely, intra-LA infusion of the DNA methyltransferase (DNMT) inhibitor 5-AZA impairs fear memory consolidation. Further, intra-LA infusion of 5-AZA was observed to impair training-related increases in H3 acetylation, and pre-treatment with TSA was observed to rescue the memory consolidation deficit induced by 5-AZA. In our final series of experiments, we show that bath application of either 5-AZA or TSA to amygdala slices results in significant impairment or enhancement, respectively, of long-term potentiation (LTP) at both thalamic and cortical inputs to the LA. Further, the deficit in LTP following treatment with 5-AZA was observed to be rescued at both inputs by co-application of TSA. Collectively, these findings provide strong support that histone acetylation and DNA methylation work in concert to regulate memory consolidation of auditory fear conditioning and associated synaptic plasticity in the LA

    Magnesia-Based Cements: A Journey of 150 Years, and Cements for the Future?

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    This review examines the detailed chemical insights that have been generated through 150 years of work worldwide on magnesium-based inorganic cements, with a focus on both scientific and patent literature. Magnesium carbonate, phosphate, silicate-hydrate, and oxysalt (both chloride and sulfate) cements are all assessed. Many such cements are ideally suited to specialist applications in precast construction, road repair, and other fields including nuclear waste immobilization. The majority of MgO-based cements are more costly to produce than Portland cement because of the relatively high cost of reactive sources of MgO and do not have a sufficiently high internal pH to passivate mild steel reinforcing bars. This precludes MgO-based cements from providing a large-scale replacement for Portland cement in the production of steel-reinforced concretes for civil engineering applications, despite the potential for CO2 emissions reductions offered by some such systems. Nonetheless, in uses that do not require steel reinforcement, and in locations where the MgO can be sourced at a competitive price, a detailed understanding of these systems enables their specification, design, and selection as advanced engineering materials with a strongly defined chemical basis
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