8 research outputs found
Correlation of <i>p</i><sub><i>META-GSA</i></sub> and <i>p</i><sub><i>SPP</i></sub> in scenario no. 8.
<p>The numbers of simulations out of a total of 500 are depicted. Gene sets are classified as significant (p ≤ 0.05) or not significant using SPP and META-GSA.</p
META-GSA: a tool for meta-analysis based on GSAs for GWASs.
<p>Genome-wide association study (GWAS); gene-set analysis (GSA); meta-analysis of GSAs (META-GSA); gene set of interest (GS, containing genes 3,5,…); complementary gene set (GS’, containing genes 1, 2, 4,…); gene-level statistic of gene <i>g</i> and study <i>s (Γ</i><sub><i>g</i>,<i>s</i></sub><i>)</i>; “enrichment score” (ES) as test statistic for GSA in study <i>s</i>.</p
Association and correlation with gene expression in the chromosome 6p21-22 region.
<p><i>LC</i>—lung cancer, <i>SLE</i>—systemic lupus erythematosus; correlation to gene expression: pooled p-values as reported by Nguyen et al., 2014 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173339#pone.0173339.ref040" target="_blank">40</a>]; association with LC: pooled p-values as reported by Timofeeva et al. 2012 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173339#pone.0173339.ref013" target="_blank">13</a>].</p
Markers with <0.5 in genes of interest on 6p21-22.
<p>Markers with <0.5 in genes of interest on 6p21-22.</p
Subgroup analysis for <i>hsa05322</i>: histological subtypes, sex, age, smoking.
<p>Subgroup analysis for <i>hsa05322</i>: histological subtypes, sex, age, smoking.</p
Characteristics of lung cancer GWASs of the International Lung Cancer Consortium (ILCCO).
<p>Characteristics of lung cancer GWASs of the International Lung Cancer Consortium (ILCCO).</p