Correlation of <i>p</i>_{<i>META-GSA</i>} and <i>p</i>_<i>SPP</i> in scenario no. 8.

<p>The numbers of simulations out of a total of 500 are depicted. Gene sets are classified as significant (p ≤ 0.05) or not significant using SPP and META-GSA.</p

META-GSA: a tool for meta-analysis based on GSAs for GWASs.

<p>Genome-wide association study (GWAS); gene-set analysis (GSA); meta-analysis of GSAs (META-GSA); gene set of interest (GS, containing genes 3,5,…); complementary gene set (GS’, containing genes 1, 2, 4,…); gene-level statistic of gene <i>g</i> and study <i>s (Γ</i>_{<i>g</i>,<i>s</i>}<i>)</i>; “enrichment score” (ES) as test statistic for GSA in study <i>s</i>.</p

Association and correlation with gene expression in the chromosome 6p21-22 region.

<p><i>LC</i>—lung cancer, <i>SLE</i>—systemic lupus erythematosus; correlation to gene expression: pooled p-values as reported by Nguyen et al., 2014 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173339#pone.0173339.ref040" target="_blank">40</a>]; association with LC: pooled p-values as reported by Timofeeva et al. 2012 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173339#pone.0173339.ref013" target="_blank">13</a>].</p

Significant results of META-GSA.

<p>Significant results of META-GSA.</p

Markers with <0.5 in genes of interest on 6p21-22.

<p>Markers with <0.5 in genes of interest on 6p21-22.</p

Subgroup analysis for <i>hsa05322</i>: histological subtypes, sex, age, smoking.

<p>Subgroup analysis for <i>hsa05322</i>: histological subtypes, sex, age, smoking.</p

Characteristics of lung cancer GWASs of the International Lung Cancer Consortium (ILCCO).

<p>Characteristics of lung cancer GWASs of the International Lung Cancer Consortium (ILCCO).</p

Study selection flow cart.

<p>Study selection flow cart.</p