11 research outputs found
Inheritance of HLA-DRB1*16:01-DQB1*05:02 in the absence of the negatively associated HLA-DRB1*15:02-DQB1*06:01.
<p>Legend: HLA-DRB1*16:01-DQB1*05:02 (16); X includes the positively associated DRB1*03:01-DQB1*02:01, DRB1*13:03-DQB1*03:01, DRB1*15:01-DQB1*06:02, DRB1*04:05-DQB1*03:01 and “neutral” haplotypes; p value (P). NA means that offspring genotypes are not possible with parental genotypes.</p
Inheritance of HLA-DRB1*16:01-DQB1*05:02 (16) in the absence of the negatively associated HLA-DRB1*15:02-DQB1*06:0, the positively associated DRB1*03:01-DQB1*02:01, DRB1*13:03-DQB1*03:01, DRB1*15:01-DQB1*06:02 and DRB1*04:05-DQB1*03:01. X = “neutral” haplotypes.
<p>X = all other alleles “neutral” haplotypes.</p><p>Legend: HLA-DRB1*16:01-DQB1*05:02 (16); “neutral” haplotypes(X); p value (P). NA means that offspring genotypes are not possible with parental genotypes.</p
The inheritance of HLA-DRB1*15:02-DQB1*06:01 (*15:02) in the absence of HLA-DRB1*16:01-DQB1*05:02.
<p>Legend: HLA-DRB1*15:02-DQB1*06:01 (*15:02); X includes the positively associated DRB1*03:01-DQB1*02:01, DRB1*13:03-DQB1*03:01, DRB1*15:01-DQB1*06:02, DRB1*04:05-DQB1*03:01 and “neutral” haplotypes; p value (P). NA means that offspring genotypes are not possible with parental genotypes.</p
Transmission disequilibrium test in 943 trios multiple sclerosis families.
<p>Legend: Transmission disequilibrium test (TDT); Transmitted (T); Not transmitted (NT); p value (P); p value corrected (Pc).</p
Multiple Sequence alignments of the predisposing and protective alleles considered in the study, with only variable amino acid residues reported, for the three DQB1 alleles (*06:01,*05:02,*06:02).
<p>Multiple Sequence alignments of the predisposing and protective alleles considered in the study, with only variable amino acid residues reported, for the three DQB1 alleles (*06:01,*05:02,*06:02).</p
Inheritance of HLA-DRB1*13:03-DQB1*03:01 in the absence of the other predisposing haplotypes DRB1*03:01-DQB1*02:01, DRB1*15:01-DQB1*16:02, DRB1*04:05-DQB1*03:01.
<p>Legend: HLA-DRB1*13:03DQB1*03:01 (13); all other haplotypes (X); p value (P). NA means that offspring genotypes are not possible with parental genotypes.</p
Inheritance of HLA-DRB1*04:05-DQB1*03:01 in the absence of the other predisposing haplotypes DRB1*03:01-DQB1* = 02:01, DRB1*13:03-DQB1*03:01, DRB1*15:01-DQB1*06:01.
<p>Legend: HLA-DRB1*04:05-DQB1*03:01 (4); all other haplotypes (X); p value (P). NA means that offspring genotypes are not possible with parental genotypes.</p
HLA DRB1*-DQB1* genotypes from 943 multiple sclerosis patients and 362 healthy siblings, plus 2829 pseudocontrols obtained from healthy parents of the 943 trio families.
<p>Legend: X = all not associated haplotypes. P values threshold is set at 0.005.</p
Sequencing of the <i>HLA-DRB1</i> promoter region in 156 subjects of Sardinian descent (112 healthy individuals and 44 multiple sclerosis affected individuals) carrying <i>HLA-DRB1</i>-<i>DQA1-DQB1</i> haplotypes.
<p>Sequencing of the <i>HLA-DRB1</i> promoter region in 156 subjects of Sardinian descent (112 healthy individuals and 44 multiple sclerosis affected individuals) carrying <i>HLA-DRB1</i>-<i>DQA1-DQB1</i> haplotypes.</p
Distribution of VDRE sequences in the promoter region of <i>HLA-DRB1</i> alleles.
<p>Distribution of VDRE sequences in the promoter region of <i>HLA-DRB1</i> alleles.</p