196 research outputs found
Resultados preliminares sobre a avaliação da estimulação transcraniana de corrente contínua (ETCC) em paciente submetido a colecistectomia videolaparoscópica eletiva por calculose biliar
Anesthesia preoperative evaluation clinic (APEC) restructuring plan for improving the quality of surgical patient flow
Otimizando o relacionamento no perioperatório : cenário propositivo geral de uma oficina interdisciplinar
Estudo sobre os níveis de purinas no líquido cefalorraquidiano de pacientes submetidos à anestesia regional
A phase II, randomized, double-blind, placebo controlled, dose-response trial of the melatonin effect on the pain threshold of healthy subjects
Background: Previous studies have suggested that melatonin may produce antinociception through peripheral and central mechanisms. Based on the preliminary encouraging results of studies of the effects of melatonin on pain modulation, the important question has been raised of whether there is a dose relationship in humans of melatonin on pain modulation. Objective: The objective was to evaluate the analgesic dose response of the effects of melatonin on pressure and heat pain threshold and tolerance and the sedative effects. Methods: Sixty-one healthy subjects aged 19 to 47 y were randomized into one of four groups: placebo, 0.05 mg/kg sublingual melatonin, 0.15 mg/kg sublingual melatonin or 0.25 mg/kg sublingual melatonin. We determine the pressure pain threshold (PPT) and the pressure pain tolerance (PPTo). Quantitative sensory testing (QST) was used to measure the heat pain threshold (HPT) and the heat pain tolerance (HPTo). Sedation was assessed with a visual analogue scale and bispectral analysis Results: Serum plasma melatonin levels were directly proportional to the melatonin doses given to each subject. We observed a significant effect associated with dose group. Post hoc analysis indicated significant differences between the placebo vs. the intermediate (0.15 mg/kg) and the highest (0.25 mg/kg) melatonin doses for all pain threshold and sedation level tests. A linear regression model indicated a significant association between the serum melatonin concentrations and changes in pain threshold and pain tolerance (R2 = 0.492 for HPT, R2 = 0.538 for PPT, R2 = 0.558 for HPTo and R2 = 0.584 for PPTo). Conclusions: The present data indicate that sublingual melatonin exerts well-defined dose-dependent antinociceptive activity. There is a correlation between the plasma melatonin drug concentration and acute changes in the pain threshold. These results provide additional support for the investigation of melatonin as an analgesic agent
Adaptação e validação para o português do Brasil das escalas de avaliação da incapacidade funcional e de catastrofismo em crianças com dor crônica
Manejo da dor aguda pós-operatória em artroplastia total de joelho: bloqueio contínuo de nervo femoral
Congruência do cateter peridural em relação ao sítio cirúrgico: plano de melhoria de qualidade usando a estratégia PDCA na equipe de cuidados pós-anestésicos do serviço de anestesia e medicina perioperatória Hospital de Clínicas de Porto Alegre
Extraindo informações socioeconômicas do local de origem, com base no CEP, de pacientes submetidos a procedimentos invasivos no Hospital de Clínicas de Porto Alegre
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