Confocal laser scanning microscopy of cellular ASP⁺ uptake via OCT1 and OCT3.

<p>Uptake of fluorescent ASP⁺ [1 μM] (green) in the absence and presence of compound <b>5</b> or TPA after 5 minutes of pre-incubation. Nuclei were stained with Draq5 [5 μM] (red). A, B: HEK-Co (control) cells, treated with Draq5 (A) or ASP⁺ plus Draq5 (B). C-E: HEK-OCT1 cells, treated with ASP⁺ plus Draq5 (C), ASP plus Draq5 plus compound <b>5</b> [15 μM] (D), or ASP⁺ plus Draq5 plus TPA [200 μM] (E). F-H: HEK-OCT3 cells, treated with ASP⁺ plus Draq5 (F), ASP⁺ plus Draq5 plus compound <b>5</b> [15 μM] (G), or ASP⁺ plus Draq5 plus TPA [200 μM] (H).</p

Interrelations across selected accuracy based, RT based measures and composite scores.

<p>Histograms on the diagonal show the distribution of the measures. Scatterplots in the lower panel represent the relationship between the measures. Blue line shows the “lowess” curve (calculated using the LOWESS smoother which uses locally-weighted polynomial regression). In the upper panel the respective Spearman correlation coefficients are shown.</p

Mean accuracy (A) and mean RT (B) as a function of ratio and presentation duration.

<p>Error bars represent standard errors of the mean.</p

Concentration-dependent inhibition of ASP⁺-uptake by OCT expressing HEK-cells.

<p>Inhibition of ASP⁺-uptake (1 μM) into HEK-OCT1 (A) and HEK-OCT3 (B) cells by TPA, <b>2</b>, <b>4</b> or <b>5</b>. The mean fluorescence intensities were normalized to uninhibited ASP⁺-uptake (N = 3).</p

Spearman correlation coefficients between all ANS measures in the 2400ms condition.

<p>Spearman correlation coefficients between all ANS measures in the 2400ms condition.</p

Descriptive statistics and split-half reliabilities of all ANS measures.

<p>Descriptive statistics and split-half reliabilities of all ANS measures.</p

Interrelations of accuracy based measures.

<p>Dots reflect predicted accuracy for a Weber fraction of 0.1 (i.e., more accurate ANS, depicted in green) and 0.5 (less accurate ANS, given in red) calculated according to the linear model and based on the item set used in our experiments. In panel (A) accuracy differed for a given numerical distance, because in our item set several ratios for a given distance were included. The lines in panel (A) reflect the numerical distance effect calculated using a generalized linear model with distance as predictor and the predicted accuracy as dependent variable, resulting from a Weber fraction of 0.1 (green) or 0.5 (red). The lines in panel (B) reflect the ratio effect, again calculated using a generalized linear model with ratio as predictor and predicted accuracy as dependent variable.</p

Spearman correlation coefficients between all ANS measures.

<p>Spearman correlation coefficients between all ANS measures.</p

Spearman correlation coefficients between all ANS measures in the 200ms condition.

<p>Spearman correlation coefficients between all ANS measures in the 200ms condition.</p

Distributions and interrelations of accuracy based measures.

<p>Histograms on the diagonal show the distribution of the measures. Scatterplots in the lower panel represent the relationship between the respective measures. Blue line shows the “lowess” curve (calculated using the LOWESS smoother which uses locally-weighted polynomial regression). In the upper panel the respective Spearman correlation coefficients are shown.</p