HIV infections prevented over 5 years from combination prevention interventions with four components.

<p>ART coverage of eligible persons who were not already receiving ART at baseline, PREP with 25% acceptance (dotted lines), 25% UAI reduction (blue lines; no UAI change are in red) and increase in HIV testing (black triangles). See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0112668#pone-0112668-t001" target="_blank">Table 1</a> for further details about the components of the prevention interventions.</p

Contribution of four components of an HIV prevention package to infections prevented.

<p>Components include ART (50% ART coverage of eligible persons from among those not already receiving ART at baseline); PREP (50% acceptance of PREP among eligible persons); UAI reduction (15% reduction), and HIV testing increase (50% reduction of persons who never have an HIV test).</p>1<p>The percent infections prevented due to component <i>i</i> refers to the percentage decrease in the 5 year cumulative HIV incidence with the HIV package that includes all four components compared to the HIV prevention package that includes three of the four components leaving out component <i>i</i>.</p>2<p>The total percent infections prevented refers to the percentage decrease in the 5 year cumulative incidence with the 4 component HIV package compared to no prevention interventions (none of the components). The total percent is not the column sum of the individual components.</p><p>Contribution of four components of an HIV prevention package to infections prevented.</p

Results from 2252 simulations of agent-based model of HIV spread among MSM in South Africa corresponding to 163 distinct combinations of HIV prevention interventions.

<p>Each point represents replicates for a particular combination of HIV prevention interventions. Plotted are the mean percentages infected over 5 years for each intervention (averaged over replicates) versus the standard deviations of those percentages. Combination prevention interventions which included a ≥25% reduction in UAIs are indicated in dark blue, all others are indicated in light blue. The data point in red corresponds to the 60 simulation runs for the control setting of no intervention.</p

Incremental contribution from adding components to three prevention packages.

<p>Table presents percent infections prevented from adding a component with 95% confidence intervals (CI). All packages include ART coverage of 50% of eligible persons (from among those not already receiving ART at baseline). Additional components include PREP (50% acceptance of PREP among eligible persons), UAI reduction (15% reduction), and HIV testing increase (50% reduction of persons who have never received an HIV test).</p>1<p>The percent infections prevented refers to the percentage decrease in the 5 year cumulative HIV incidence with the HIV package that includes the additional component into the base package.</p><p>Incremental contribution from adding components to three prevention packages.</p

Main characteristics of agent-based model for combination HIV prevention among MSM in peri-urban South Africa (additional information and specific parameter values are in the Supporting Information S1).

<p>Main characteristics of agent-based model for combination HIV prevention among MSM in peri-urban South Africa (additional information and specific parameter values are in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0112668#pone.0112668.s001" target="_blank">Supporting Information S1</a>).</p

General characteristics of studies measuring stigma associated with men who have sex with men (MSM) and stigma associated with sex workers (SW) in articles from 2004-2014.

<p>General characteristics of studies measuring stigma associated with men who have sex with men (MSM) and stigma associated with sex workers (SW) in articles from 2004-2014.</p

Percentage validated scales used to measure stigma associated with sex workers (SW), SW and men who have sex with men (MSM), and MSM in articles from 2004-2014.

<p>Percentage validated scales used to measure stigma associated with sex workers (SW), SW and men who have sex with men (MSM), and MSM in articles from 2004-2014.</p

Geographic distribution of all included articles measuring stigma toward men who have sex with men (MSM) and stigma toward sex workers (SW) by country, 2004-2014.

<p>Not included in Fig 2 are studies that were Europe-wide [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0188393#pone.0188393.ref030" target="_blank">30</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0188393#pone.0188393.ref031" target="_blank">31</a>] and global without countries specified [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0188393#pone.0188393.ref032" target="_blank">32</a>].</p

Distribution of identified geographic locations in included stigma measurement articles for sex workers (SW) only, SW and men who have sex with men (MSM), MSM only, and in papers including transgender persons, 2004-2014^a.

<p>Distribution of identified geographic locations in included stigma measurement articles for sex workers (SW) only, SW and men who have sex with men (MSM), MSM only, and in papers including transgender persons, 2004-2014<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0188393#t002fn001" target="_blank">^a</a>.</p

Flowchart of screening process for inclusion of articles measuring stigma affecting men who have sex with men (MSM) and stigma affecting sex workers (SW), 2004-2014.

<p>Flowchart of screening process for inclusion of articles measuring stigma affecting men who have sex with men (MSM) and stigma affecting sex workers (SW), 2004-2014.</p