Nathan Sauer Interview 2019

This is an interview with Nathan Sauer, Classroom and University Technology and Support at Western Oregon University. He discusses how he came to work for Western Oregon University, and what his day-to-day duties are. He discusses how his job has evolved over the years, and what his goals are for his continued service. Mr. Sauer has a unique and worthwhile point of view on the University

Use of the Spine AdVerse Events Severity (SAVES) System to Categorize and Report Adverse Events in Spine Surgery.

Introduction: Analysis of adverse events (AEs) in spine surgery has historically been retrospective, utilizing hospital administrative data. Our objective was to determine the incidence, severity and effect on hospital length of stay (LOS) for AEs in spine surgery using the Spine AdVerse Events Severity (SAVES V2) system. Methods: AEs for all surgical spine patients at our institution were prospectively collected for 18 months and correlated with retrospective data from operative reports and H&Ps. Statistical analyses compared patient demographics, diagnoses, and surgical characteristics to hospital length of stay and likelihood of adverse events. Results: This system captured 75% (765/977) of surgical cases for all indications over the study period. 73% (541/743) of patients experienced at least one AE, with an average of 1.2 AEs per patient (range 0-5). The most common AEs were pain control (31%), urinary retention (9.7%), wound infection (6.3%), and incidental durotomy (5.8%). For patients experiencing at least one AE, 30% had no effect on LOS, 48% increased LOS by 1-2 days, 15% increased LOS by 3-7 days, and 7% had prolonged LOS greater than 8 days. Our system captured 25.4% more adverse events (60.0% vs. 34.6%) than hospital administrative data. Univariate analysis revealed patient age, emergent surgery, diagnostic and surgical categories, and spine region to be predictors of both AEs and LOS. Instrumentation was predictive of increased LOS but not AEs. The type of AE was strongly associated with LOS. Multivariable analysis of AE likelihood demonstrated emergent surgery to be the strongest independent predictor with an adjusted odds ratio of 8.5 versus elective surgery. Discussion: Spine surgery is associated with a high incidence of adverse events, which often prolong hospital length of stay. Better characterization of adverse events and their predictors could lead to improved management strategies that reduce patient morbidity and mortality

Staphylococcus aureus Redirects Central Metabolism to Increase Iron Availability

Staphylococcus aureus pathogenesis is significantly influenced by the iron status of the host. However, the regulatory impact of host iron sources on S. aureus gene expression remains unknown. In this study, we combine multivariable difference gel electrophoresis and mass spectrometry with multivariate statistical analyses to systematically cluster cellular protein response across distinct iron-exposure conditions. Quadruplicate samples were simultaneously analyzed for alterations in protein abundance and/or post-translational modification state in response to environmental (iron chelation, hemin treatment) or genetic (Δfur) alterations in bacterial iron exposure. We identified 120 proteins representing several coordinated biochemical pathways that are affected by changes in iron-exposure status. Highlighted in these experiments is the identification of the heme-regulated transport system (HrtAB), a novel transport system which plays a critical role in staphylococcal heme metabolism. Further, we show that regulated overproduction of acidic end-products brought on by iron starvation decreases local pH resulting in the release of iron from the host iron-sequestering protein transferrin. These findings reveal novel strategies used by S. aureus to acquire scarce nutrients in the hostile host environment and begin to define the iron and heme-dependent regulons of S. aureus

Resolution of Proliferation Issues for a Sodium Fast Reactor Blanket

Breeding blankets are of interest for a sodium fast reactor (SFR) as they allow for small cores to have positive breeding gains. However, because they breed very high-quality plutonium, core designers are not currently encouraged to employ blankets. After verifying that the ERANOS code was in good agreement with BGcore, a Monte Carlo-based depletion system, it was shown that an SFR blanket design could breed less attractive plutonium than light water reactor (LWR)-bred plutonium for making a nuclear explosive device. Minor actinide (MA) doping and moderator addition were the two options studied. This study shows that it is possible to build an SFR with a secure blanket with MA addition; at steady state MAs from approximately 1.5 LWRs are required per SFR [both rated at 1 GW(electric)]

A metallic phase in quantum Hall systems

The electronic eigenstates of a quantum Hall (QH) system are chiral states. Strong inter-Landau-band mixings among these states can occur when the bandwidth is comparable to the spacing of two adjacent Landau bands. We show that mixing of localized states with opposite chirality can delocalize electronic states. Based on numerical results, we propose the existence of a metallic phase between two adjacent QH phases and between a QH phase and the insulating phase. This result is consistent with non-scaling behaviors observed in recent experiments on quantum-Hall-liquid-to-insulator transition.Comment: 5 pages, 3 figures. Will be published in Phys. Rev. Let