Black hole entropy and moduli-dependent species scale

We provide a moduli-dependent definition of species scale in quantum gravity based on black hole arguments. Concretely, it is derived from of a lower bound on the entropy of extremal black holes with higher curvature corrections, which ensures that the black hole can be reliably described within the effective theory. By demanding that our definition coincides with a recent proposal for a moduli-dependent species scale motivated from the topological string, we conclude that the conjecture $\mathcal{Z}_{BH} = |\mathcal{Z}_{\rm top}|^2$ relating the black hole to the topological string partition functions should hold, at least within the regime of validity of our analysis.Comment: 14 pages; v2: minor revisions, published on PL

Twisting DNA by salt

The structure and properties of DNA depend on the environment, in particular the ion atmosphere. Here, we investigate how DNA twist -one of the central properties of DNA- changes with concentration and identity of the surrounding ions. To resolve how cations influence the twist, we combine single-molecule magnetic tweezer experiments and extensive all-atom molecular dynamics simulations. Two interconnected trends are observed for monovalent alkali and divalent alkaline earth cations. First, DNA twist increases monotonously with increasing concentration for all ions investigated. Second, for a given salt concentration, DNA twist strongly depends on cation identity. At 100 mM concentration, DNA twist increases as Na+ + + 2+ + ≈ Cs+ 2+ 2+ 2+. Our molecular dynamics simulations reveal that preferential binding of the cations to the DNA backbone or the nucleobases has opposing effects on DNA twist and provides the microscopic explanation of the observed ion specificity. However, the simulations also reveal shortcomings of existing force field parameters for Cs+ and Sr2+. The comprehensive view gained from our combined approach provides a foundation for understanding and predicting cation-induced structural changes both in nature and in DNA nanotechnology

Twisting DNA by salt

The structure and properties of DNA depend on the environment, in particular the ion atmosphere. Here, we investigate how DNA twist-one of the central properties of DNA-changes with concentration and identity of the surrounding ions. To resolve how cations influence the twist, we combine single-molecule magnetic tweezer experiments and extensive all-atom molecular dynamics simulations. Two interconnected trends are observed for monovalent alkali and divalent alkaline earth cations. First, DNA twist increases monotonously with increasing concentration for all ions investigated. Second, for a given salt concentration, DNA twist strongly depends on cation identity. At 100 mM concentration, DNA twist increases as Na+ < K+ < Rb+ < Ba2+ < Li+ ≈ Cs+ < Sr2+ < Mg2+ < Ca2+. Our molecular dynamics simulations reveal that preferential binding of the cations to the DNA backbone or the nucleobases has opposing effects on DNA twist and provides the microscopic explanation of the observed ion specificity. However, the simulations also reveal shortcomings of existing force field parameters for Cs+ and Sr2+. The comprehensive view gained from our combined approach provides a foundation for understanding and predicting cation-induced structural changes both in nature and in DNA nanotechnology

Black hole entropy and moduli-dependent species scale

We provide a moduli-dependent definition of species scale in quantum gravity based on black hole arguments. Concretely, it is derived from a lower bound on the entropy of extremal black holes with higher curvature corrections, which ensures that the black hole can be reliably described within the effective theory. By demanding that our definition coincides with a recent proposal for a moduli-dependent species scale motivated from the topological string, we conclude that the conjecture ZBH=|Ztop|2 relating the black hole to the topological string partition functions should hold, at least within the regime of validity of our analysis