Correlation among different KRAS alterations, genetic co-mutations and PD-L1 expression in patients treated with immunotherapy in metastatic NSCLC

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53pimmune related adverse events correlate with clinical outcomes in non small cell lung cancer nsclc patients treated with nivolumab in the italian expanded access programme

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Ruolo del palloncino intragastrico in chirurgia bariatrica

Gli Autori presentano la loro casistica sul palloncino intragastrico (BIB) nel trattamento dell?obesità. Il BIB è un dispositivo meccanico restrittivo, costitutito da un involucro in silicone che viene introdotto in cavità gastrica per via endoscopica, riempito con 500 cc di soluzione fisiologica colorata con blu di metilene e mantenuto in situ per 6 mesi. Nell?arco di 2 anni sono stati posizionati 98 palloncini intragastrici a 88 pazienti la cui età media era di 37.1 anni e l?indice di massa corporea (BMI) medio di 41.9; l?eccesso ponderale medio era 47,6 kg. Le complicanze registrate sono state l?intolleranza, il reflusso gastro-esfageo (RGE), la rottura e/o la desufflazione del palloncino e meteorismo. Il BIB è risultata una procedura efficace nel trattamento temporaneo dell?obesità potendo indurre un soddisfacente calo ponderale e un miglioramento a breve termine delle comorbilità. English version Intragastric balloon (BIB) is a mechanical restrictive device formed by a silicone wrapper inserted endoscopically in the stomach, filled with 500 cc of phisiological blue metilene solution and kept in situ for 6 months. In two years 98 intragastric balloon have been set in 88 patients at the average age of 37.1 years, of 41.9 of BMI and 47.6 kg of weight. Complications were intolerance, gastro-oesophageal reflux, break and/or deflation and meteorism. BIB is an effective procedure in obesity temporary treatment leading a satisfactory loss of weight and a short-term comorbility improvement

Formazione retroperitonale: caso clinico

Gli Autori riportano un caso clinico di ?formazione? retroperitoneale recentemente occorso alla loro osservazione. Delineando le diverse ipotesi diagnostiche, alla luce dell?evoluzione del quadro clinico e radiografico, ne ipotizzano la natura traumatica e la riconoscono come ematoma renale sottocapsulare verificatosi due anni prima e complicato recentemente da rottura capsulare, con conseguente spandimento ematico nel retroperitoneo e superficializzazione della raccolta, parzialmente ascessualizzata, in sede lombare sinistra. English version The Authors discuss about a case of retroperitoneal mass, recently observed in their Institution. About the nature of the mass, by the imaging and clinical evolution, the Authors suppose a traumatic genesis: subcapsular renal hematoma, occourred 2 years before, broken and expanded in retroperitoneal space and then superficialized in the left lumbar region

Clinical, histological, and virological features of hepatitis C virus carriers with persistently normal or abnormal alanine transaminase levels

This study was aimed to evaluate demographic, clinical, histological, and virological characteristics of 46 hepatitis C virus (HCV) carriers with persistently normal alanine transaminase (ALT) levels and to compare the results with those obtained in a group of 52 HCV-RNA-positive patients with elevated ALT levels. Subjects with normal ALT were more often females (P < .001), were more likely to be asymptomatic (P < .001), and have a lower incidence of risk factors for HCV transmission (P < .01). All patients with normal ALT had significant histological liver damage. The mean grading and staging did not differ between patients with normal and those with raised ALT concentrations. Moderate to severe hepatitis was more frequently found among subjects with normal than with elevated ALT. HCV genotype 2a was far more common in subjects with normal (43%) than with abnormal ALT levels (6%; P < .002), genotype 1b being more frequent in these latter (50% vs. 17%; P < .001). Patients with normal ALT levels had similar serum HCV-RNA titers than subjects with raised ALT. Neither HCV genotype distribution nor viral load correlated with the severity of liver damage. We conclude that significant liver disease may occur irrespective of clinical symptoms, ALT levels, HCV genotypes, and viral load