DEVELOPING AN ACADEMIC INSTITUTIONAL REPOSITORY. THE CASE OF THE OPEN UNIVERSITY OF CYPRUS

The amount of digital content produced nowadays, is enormous. Academic institutions produce and make available a plethora of digital objects like research articles, theses, dissertations, reports, audiovisual collections and many others. In addition, academic libraries digitize materials to create collections of historical, political and scientific significance and are responsible for keeping, preserving, archiving and publishing the content produced by their students and academic personnel. Aiming in that direction, the Open University of Cyprus, an institution responsible for delivering distance learning at the Republic of Cyprus, designed and deployed “Kypseli” Institutional Repository. In this work, the authors depict the methodology and tools used for building an academic institutional repository using open source tools at the Open University of Cyprus. Moreover, the procedures used for publishing content and the integration of the repository to the rest of the university’s infrastructure are analysed, along with the challenges faced during the implementation and deployment phase. In addition, a number of metrics are presented, accompanied by statistics of usage

Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no current cure. A prominent, yet poorly treated feature of dystrophic muscle is the dysregulation of energy homeostasis which may be associated with intrinsic defects in key energy systems and promote muscle wasting. As such, supplementative nutriceuticals that target and augment the bioenergetical expansion of the metabolic pathways involved in cellular energy production have been widely investigated for their therapeutic efficacy in the treatment of DMD. We describe the metabolic nuances of dystrophin-deficient skeletal muscle and review the potential of various metabogenic and nutriceutical compounds to ameliorate the pathological and clinical progression of the disease

Interactive Consistency in practical, mostly-asynchronous systems

Interactive consistency is the problem in which n nodes, where up to t may be byzantine, each with its own private value, run an algorithm that allows all non-faulty nodes to infer the values of each other node. This problem is relevant to critical applications that rely on the combination of the opinions of multiple peers to provide a service. Examples include monitoring a content source to prevent equivocation or to track variability in the content provided, and resolving divergent state amongst the nodes of a distributed system. Previous works assume a fully synchronous system, where one can make strong assumptions such as negligible message delivery delays and/or detection of absent messages. However, practical, real-world systems are mostly asynchronous, i.e., they exhibit only some periods of synchrony during which message delivery is timely, thus requiring a different approach. In this paper, we present a thorough study on practical interactive consistency. We leverage the vast prior work on broadcast and byzantine consensus algorithms to design, implement and evaluate a set of algorithms, with varying timing assumptions and message complexity, that can be used to achieve interactive consistency in real-world distributed systems. We provide a complete, open-source implementation of each proposed interactive consistency algorithm by building a multi-layered stack of protocols that include several broadcast protocols, as well as a binary and a multi-valued consensus protocol. Most of these protocols have never been implemented and evaluated in a real system before. We analyze the performance of our suite of algorithms experimentally by engaging in both single instance and multiple parallel instances of each alternative.Comment: 13 pages, 10 figure

Similarities in Metabolic Flexibility and Hunger Hormone Ghrelin Exist Between FTO Gene Variants in Response to an Acute Dietary Challenge

The rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene has been associated with obesity, and studies have also shown that environmental/lifestyle interaction such as dietary intake might mediate this effect. The current study investigates the postprandial hormonal regulators of hunger and indirect markers of substrate utilisation and metabolic flexibility following a dietary challenge to determine if suppression of circulating ghrelin levels and/or reduced metabolic flexibility exist between FTO genotypes. One hundred and forty seven healthy, sedentary males and females (29.0 ± 0.7 yrs; 70.2 ± 1.1 kg; 169.1 ± 0.8 cm; 24.5 ± 0.3 kg/m2) complete a single experimental session. Anthropometric measures, circulating levels of active ghrelin, insulin and glucose, and substrate oxidation via indirect calorimetry, are measured pre-prandial and/or post-prandial. The FTO rs9939609 variant is genotyped using a real-time polymerase chain reaction. Metabolic flexibility (∆RER) is similar between FTO genotypes of the rs9939609 (T > A) polymorphism (p > 0.05). No differences in pre-prandial and/or postprandial substrate oxidation, plasma glucose, serum insulin or ghrelin are observed between genotypes (p > 0.05). These observations are independent of body mass index and gender. Altered postprandial responses in hunger hormones and metabolic flexibility may not be a mechanism by which FTO is associated with higher BMI and obesity in healthy, normal-weighted individuals

Whey protein isolate attenuates strength decline after eccentrically-induced muscle damage in healthy individuals

We examined the effects of short-term consumption of whey protein isolate on muscle proteins and force recovery after eccentrically-induced muscle damage in healthy individuals. The major finding of this investigation was that whey protein isolate supplementation attenuated the impairment in isometric and isokinetic muscle forces during recovery from exercise-induced muscle injury