330 research outputs found
Evaluating the Transient Radiant Heat Flux Impacts to Occupied Buildings
PresentationTraditional methods of evaluating radiant heat impacts on occupied buildings typically rely on a threshold radiant heat flux value to evaluate occupant vulnerability. While this is acceptable within the methodology of fire hazard evaluation presented in the API RP 752 standard, the approach does not account for structure properties, the transient nature of the fire, or duration of exposure. These factors are an important part of describing the potential impact on occupied buildings, as well as the vulnerability of the building’s occupants. Because API RP 752 does not provide any specific guidance on these topics, the specific evaluation of a building and its response to thermal radiation is left to the analyst. Previous work applied first principle numerical tools to define the impacts from continuous external fires. This paper continues that work to evaluate transient thermal loading on the building exterior and heat transfer through the building materials to better determine building occupant vulnerability. This work will help to define the limits of radiant heat dose for occupied buildings that may be exposed to external fires
Structural abnormalities of the optic nerve and retina in Huntington’s disease pre-clinical and clinical settings
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein. HD-related pathological remodelling has been reported in HD mouse models and HD carriers. In this study, we studied structural abnormalities in the optic nerve by employing Spectral Domain Optical Coherence Tomography (SD-OCT) in pre-symptomatic HD carriers of Caucasian origin. Transmission Electron Microscopy (TEM) was used to investigate ultrastructural changes in the optic nerve of the well-established R6/2 mouse model at the symptomatic stage of the disease. We found that pre-symptomatic HD carriers displayed a significant reduction in the retinal nerve fibre layer (RNFL) thickness, including specific quadrants: superior, inferior and temporal, but not nasal. There were no other significant irregularities in the GCC layer, at the macula level and in the optic disc morphology. The ultrastructural analysis of the optic nerve in R6/2 mice revealed a significant thinning of the myelin sheaths, with a lamellar separation of the myelin, and a presence of myelonoid bodies. We also found a significant reduction in the thickness of myelin sheaths in peripheral nerves within the choroids area. Those ultrastructural abnormalities were also observed in HD photoreceptor cells that contained severely damaged membrane disks, with evident vacuolisation and swelling. Moreover, the outer segment of retinal layers showed a progressive disintegration. Our study explored structural changes of the optic nerve in pre- and clinical settings and opens new avenues for the potential development of biomarkers that would be of great interest in HD gene therapies
Run Scenarios for the Linear Collider
Scenarios are developed for runs at a Linear Collider, in the case that there
is a rich program of new physics.Comment: 12 pages, 10 tables, Latex; Snowmass 2001 plenary repor
Gamma-ray Observations Under Bright Moonlight with VERITAS
Imaging atmospheric Cherenkov telescopes (IACTs) are equipped with sensitive
photomultiplier tube (PMT) cameras. Exposure to high levels of background
illumination degrades the efficiency of and potentially destroys these
photo-detectors over time, so IACTs cannot be operated in the same
configuration in the presence of bright moonlight as under dark skies. Since
September 2012, observations have been carried out with the VERITAS IACTs under
bright moonlight (defined as about three times the night-sky-background (NSB)
of a dark extragalactic field, typically occurring when Moon illumination >
35%) in two observing modes, firstly by reducing the voltage applied to the
PMTs and, secondly, with the addition of ultra-violet (UV) bandpass filters to
the cameras. This has allowed observations at up to about 30 times previous NSB
levels (around 80% Moon illumination), resulting in 30% more observing time
between the two modes over the course of a year. These additional observations
have already allowed for the detection of a flare from the 1ES 1727+502 and for
an observing program targeting a measurement of the cosmic-ray positron
fraction. We provide details of these new observing modes and their performance
relative to the standard VERITAS observations
Gamma-ray observations of Tycho's SNR with VERITAS and Fermi
High-energy gamma-ray emission from supernova remnants (SNRs) has provided a
unique perspective for studies of Galactic cosmic-ray acceleration. Tycho's SNR
is a particularly good target because it is a young, type Ia SNR that is
well-studied over a wide range of energies and located in a relatively clean
environment. Since the detection of gamma-ray emission from Tycho's SNR by
VERITAS and Fermi-LAT, there have been several theoretical models proposed to
explain its broadband emission and high-energy morphology. We report on an
update to the gamma-ray measurements of Tycho's SNR with 147 hours of VERITAS
and 84 months of Fermi-LAT observations, which represents about a factor of two
increase in exposure over previously published data. About half of the VERITAS
data benefited from a camera upgrade, which has made it possible to extend the
TeV measurements toward lower energies. The TeV spectral index measured by
VERITAS is consistent with previous results, but the expanded energy range
softens a straight power-law fit. At energies higher than 400 GeV, the
power-law index is . It
is also softer than the spectral index in the GeV energy range, , measured by this study using
Fermi--LAT data. The centroid position of the gamma-ray emission is coincident
with the center of the remnant, as well as with the centroid measurement of
Fermi--LAT above 1 GeV. The results are consistent with an SNR shell origin of
the emission, as many models assume. The updated spectrum points to a lower
maximum particle energy than has been suggested previously.Comment: Accepted for publication in The Astrophysical Journa
Dark Matter Constraints from a Joint Analysis of Dwarf Spheroidal Galaxy Observations with VERITAS
We present constraints on the annihilation cross section of WIMP dark matter
based on the joint statistical analysis of four dwarf galaxies with VERITAS.
These results are derived from an optimized photon weighting statistical
technique that improves on standard imaging atmospheric Cherenkov telescope
(IACT) analyses by utilizing the spectral and spatial properties of individual
photon events. We report on the results of 230 hours of observations of
five dwarf galaxies and the joint statistical analysis of four of the dwarf
galaxies. We find no evidence of gamma-ray emission from any individual dwarf
nor in the joint analysis. The derived upper limit on the dark matter
annihilation cross section from the joint analysis is at 1 TeV for the bottom quark () final state,
at 1 TeV for the tau lepton
() final state and at 1 TeV for the gauge boson () final state.Comment: 14 pages, 9 figures, published in PRD, Ascii tables containing
annihilation cross sections limits are available for download as ancillary
files with readme.txt file description of limit
Very-high-energy observations of the binaries V 404 Cyg and 4U 0115+634 during giant X-ray outbursts
Transient X-ray binaries produce major outbursts in which the X-ray flux can
increase over the quiescent level by factors as large as . The low-mass
X-ray binary V 404 Cyg and the high-mass system 4U 0115+634 underwent such
major outbursts in June and October 2015, respectively. We present here
observations at energies above hundreds of GeV with the VERITAS observatory
taken during some of the brightest X-ray activity ever observed from these
systems. No gamma-ray emission has been detected by VERITAS in 2.5 hours of
observations of the microquasar V 404 Cyg from 2015, June 20-21. The upper flux
limits derived from these observations on the gamma-ray flux above 200 GeV of F
cm s correspond to a tiny fraction (about
) of the Eddington luminosity of the system, in stark contrast to that
seen in the X-ray band. No gamma rays have been detected during observations of
4U 0115+634 in the period of major X-ray activity in October 2015. The flux
upper limit derived from our observations is F cm
s for gamma rays above 300 GeV, setting an upper limit on the ratio of
gamma-ray to X-ray luminosity of less than 4%.Comment: Accepted for publication in the Astrophysical Journa
Measurement of Cosmic-ray Electrons at TeV Energies by VERITAS
Cosmic-ray electrons and positrons (CREs) at GeV-TeV energies are a unique
probe of our local Galactic neighborhood. CREs lose energy rapidly via
synchrotron radiation and inverse-Compton scattering processes while
propagating within the Galaxy and these losses limit their propagation
distance. For electrons with TeV energies, the limit is on the order of a
kiloparsec. Within that distance there are only a few known astrophysical
objects capable of accelerating electrons to such high energies. It is also
possible that the CREs are the products of the annihilation or decay of heavy
dark matter (DM) particles. VERITAS, an array of imaging air Cherenkov
telescopes in southern Arizona, USA, is primarily utilized for gamma-ray
astronomy, but also simultaneously collects CREs during all observations. We
describe our methods of identifying CREs in VERITAS data and present an energy
spectrum, extending from 300 GeV to 5 TeV, obtained from approximately 300
hours of observations. A single power-law fit is ruled out in VERITAS data. We
find that the spectrum of CREs is consistent with a broken power law, with a
break energy at 710 40 140 GeV.Comment: 17 pages, 2 figures, accepted for publication in PR
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