38 research outputs found
Mass Determination Method for the Right and Left Selectron Above Production Threshold
The determination of the masses of Supersymmetric particles such as the
Selectron for energies above threshold using the energy end-points method is
subject to signal deconvolution difficulties and to Standard Model and
Supersymmetric backgrounds. The important features of Right and Left Selectron
production are used to design an experimentally robust method both for
determining the Left and Right Selectron masses, the Neutralino mass and for
suppresing backgrounds. The mass resolution is an order of magnitude better
than in previous methods. Additional features, such as the determination of the
relative leptonic branching ratios of the selectron decay are present in the
method.Comment: 4 pages in RevTex (Latex) format and 4 figures in eps forma
Contemporary Homozygous Familial Hypercholesterolemia in the United States: Insights From the CASCADE FH Registry
Background Homozygous familial hypercholesterolemia (HoFH) is a rare, treatmentâresistant disorder characterized by earlyâonset atherosclerotic and aortic valvular cardiovascular disease if left untreated. Contemporary information on HoFH in the United States is lacking, and the extent of underdiagnosis and undertreatment is uncertain. Methods and Results Data were analyzed from 67 children and adults with clinically diagnosed HoFH from the CASCADE (Cascade Screening for Awareness and Detection) FH Registry. Genetic diagnosis was confirmed in 43 patients. We used the clinical characteristics of genetically confirmed patients with HoFH to query the Family Heart Database, a US anonymized payer health database, to estimate the number of patients with similar lipid profiles in a ârealâworldâ setting. Untreated lowâdensity lipoprotein cholesterol levels were lower in adults than children (533 versus 776âmg/dL; P=0.001). At enrollment, atherosclerotic cardiovascular disease and supravalvular and aortic valve stenosis were present in 78.4% and 43.8% and 25.5% and 18.8% of adults and children, respectively. At most recent followâup, despite multiple lipidâlowering treatment, lowâdensity lipoprotein cholesterol goals were achieved in only a minority of adults and children. Query of the Family Heart Database identified 277 individuals with profiles similar to patients with genetically confirmed HoFH. Advanced lipidâlowering treatments were prescribed for 18%; 40% were on no lipidâlowering treatment; atherosclerotic cardiovascular disease was reported in 20%; familial hypercholesterolemia diagnosis was uncommon. Conclusions Only patients with the most severe HoFH phenotypes are diagnosed early. HoFH remains challenging to treat. Results from the Family Heart Database indicate HoFH is systemically underdiagnosed and undertreated. Earlier screening, aggressive lipidâlowering treatments, and guideline implementation are required to reduce disease burden in HoFH
Influence of temperature on induction of chill-coma, electrical activity of the nervous system, and movement of the American cockroach, Periplaneta americana
The Bifurcation Point of the Oxygen Reduction Reaction on Au-Pd Nanoalloys
The oxygen reduction reaction is of major importance in energy conversion and storage. Controlling electrocatalytic activity and its selectivity remains a challenge of modern electrochemistry. Here, first principle calculations and analysis of experimental data unravel the mechanism of this reaction on Au-Pd nanoalloys in acid media. A mechanistic model is proposed from comparison of electrocatalysis of oxygen and hydrogen peroxide reduction on different Au-Pd ensembles. A H2O production channel on contiguous Pd sites proceeding through intermediates different from H2O2 and OOHÏ adsorbate is identified as the bifurcation point for the two reaction pathway alternatives to yield either H2O or H2O2. H2O2 is a leaving group, albeit reduction of H2O2 to H2O can occur by electrocatalytic HO-OH dissociation that is affected by the presence of adsorbed OOHÏ. Similarities and differences between electrochemical and direct synthesis from H2 + O2 reaction on Au-Pd nanoalloys are discussed
How X-37 Technology Demonstration Supports Reusable Launch Vehicles
This presentation discusses, in viewgraph form, how X-37 Technology Demonstration Supports Reusable Launch Vehicles. The topics include: 1) X-37 Program Objectives; 2) X-37 Description; 3) X-37 Vehicle Characteristics; 4) X-37 Expands the Testbed Envelope to Orbital Capability; 5) Overview of X-37 Flight Test Program; 6) Thirty-Nine Technologies and Experiments are Being Demonstrated on the X-37; 7) X-37 Airframe/Structures Technologies; 8) X-37 Mechanical, Propulsion, and Thermal System Technologies and Experiments; 9) X-37 GN&C Technologies; 10) X-37 Avionics, Power, and Software Technologies and Experiments; and 11) X-37 Technologies and Experiments Support Reusable Launch Vehicle Needs