693 research outputs found
LabVIEW intègre et accélère les processus de développement en physique expérimentale
La physique expérimentale a massivement recours à la programmation d'instruments. Nous présentons deux réalisations LabVIEW du LPSC, pour les expériences GRAAL et PLANCK. En nous appuyant sur ces exemples nous dégagerons certaines qualités qui permetent à LabVIEW d'intégrer l'environnement et les méthodes de la recherche. Enfin nous examinerons des points de concordance profonds entre la technologie LabVIEW et les contraintes techniques de la programmation des expériences
Results of a self-triggered prototype system for radio-detection of extensive air showers at the Pierre Auger Observatory
We describe the experimental setup and the results of RAuger, a small
radio-antenna array, consisting of three fully autonomous and self-triggered
radio-detection stations, installed close to the center of the Surface Detector
(SD) of the Pierre Auger Observatory in Argentina. The setup has been designed
for the detection of the electric field strength of air showers initiated by
ultra-high energy cosmic rays, without using an auxiliary trigger from another
detection system. Installed in December 2006, RAuger was terminated in May 2010
after 65 registered coincidences with the SD. The sky map in local angular
coordinates (i.e., zenith and azimuth angles) of these events reveals a strong
azimuthal asymmetry which is in agreement with a mechanism dominated by a
geomagnetic emission process. The correlation between the electric field and
the energy of the primary cosmic ray is presented for the first time, in an
energy range covering two orders of magnitude between 0.1 EeV and 10 EeV. It is
demonstrated that this setup is relatively more sensitive to inclined showers,
with respect to the SD. In addition to these results, which underline the
potential of the radio-detection technique, important information about the
general behavior of self-triggering radio-detection systems has been obtained.
In particular, we will discuss radio self-triggering under varying local
electric-field conditions.Comment: accepted for publication in JINS
Molecular Bremsstrahlung Radiation at GHz Frequencies in Air
A detection technique for ultra-high energy cosmic rays, complementary to the
fluorescence technique, would be the use of the molecular Bremsstrahlung
radiation emitted by low-energy ionization electrons left after the passage of
the showers in the atmosphere. In this article, a detailed estimate of the
spectral intensity of photons at ground level originating from this radiation
is presented. The spectral intensity expected from the passage of the
high-energy electrons of the cascade is also estimated. The absorption of the
photons in the plasma of electrons/neutral molecules is shown to be negligible.
The obtained spectral intensity is shown to be W cm
GHz at 10 km from the shower core for a vertical shower induced by a
proton of eV. In addition, a recent measurement of Bremsstrahlung
radiation in air at gigahertz frequencies from a beam of electrons produced at
95 keV by an electron gun is also discussed and reasonably reproduced by the
model.Comment: 20 pages, 9 figures, figures (2,4,7) improved in v2, accepted by
Phys. Rev.
Experimental study of a liquid Xenon PET prototype module
A detector using liquid Xenon in the scintillation mode is studied for
Positron Emission Tomography (PET). The specific design aims at taking full
advantage of the liquid Xenon properties. It does feature a promising
insensitive to any parallax effect. This work reports on the performances of
the first LXe prototype module, equipped with a position sensitive PMT
operating in the VUV range (178 nm).Comment: Proc. of the 7th International Workshops on Radiation Imaging
Detectors (IWORID-7), Grenoble, France 4-7 July 200
Microenvironment in neuroblastoma: Isolation and characterization of tumor-derived mesenchymal stromal cells
Background: It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from tumor tissues of pediatric patients diagnosed with neuroblastomas (NB-MSCs) to define interactions with the tumor microenvironment. Methods: Specimens were obtained from 7 pediatric patients diagnosed with neuroblastoma (NB). Morphology, immunophenotype, differentiation capacity, proliferative growth, expression of stemness and neural differentiation markers were evaluated. Moreover, the ability of cells to modulate the immune response, i.e. inhibition of phytohemagglutinin (PHA) activated peripheral blood mononuclear cells (PBMCs) and natural killer (NK) cytotoxic function, was examined. Gene expression profiles, known to be related to tumor cell stemness, Wnt pathway activation, epithelial-mesenchymal transition (EMT) and tumor metastasis were also evaluated. Healthy donor bone marrow-derived MSCs (BM-MSC) were employed as controls. Results: NB-MSCs presented the typical MSC morphology and phenotype. They showed a proliferative capacity superimposable to BM-MSCs. Stemness marker expression (Sox2, Nanog, Oct3/4) was comparable to BM-MSCs. NB-MSC in vitro osteogenic and chondrogenic differentiation was similar to BM-MSCs, but NB-MSCs lacked adipogenic differentiation capacity. NB-MSCs reached senescence phases at a median passage of P7 (range, P5-P13). NB-MSCs exhibited greater immunosuppressive capacity on activated T lymphocytes at a 1:2 (MSC: PBMC) ratio compared with BM-MSCs (p = 0.018). NK cytotoxic activity was not influenced by co-culture, either with BM-MSCs or NB-MSCs. Flow-cytometry cell cycle analysis showed that NB-MSCs had an increased number of cells in the G0-G1 phase compared to BM-MSCs. Transcriptomic profiling results indicated that NB-MSCs were enriched with EMT genes compared to BM-MSCs. Conclusions: We characterized the biological features, the immunomodulatory capacity and the gene expression profile of NB-MSCs. The NB-MSC gene expression profile and their functional properties suggest a potential role in promoting tumor escape, invasiveness and metastatic traits of NB cancer cells. A better understanding of the complex mechanisms underlying the interactions between NB cells and NB-derived MSCs should shed new light on potential novel therapeutic approaches
Laser-Induced Graphenization of PDMS as Flexible Electrode for Microsupercapacitors
Laser graphenization of polymeric surfaces has emerged as one of the most promising technologies to fabricate flexible electrodes. Unfortunately, despite the large number of materials suitable for laser-induced graphene (LIG) fabrication, there is a lack of stretchable polymers, hindering the full exploitation of LIG for flexible electronics. Herein, the laser graphenization of polydimethylsiloxane (PDMS), the most exploited elastomeric substrate for flexible electronic device fabrication, is proposed for the first time. The low carbon content and the absence of aromatic structures strongly limit the graphenization process resulting in limited conduction properties. Nevertheless, by adding triethylene glycol (TEG) as carbon source into the PDMS matrix, it is possible to improve the graphenization and to reduce the sheet resistance of the written LIG by two orders of magnitude down to 130 ohm sq−1. The PDMS-TEG material becomes a suitable candidate for flexible microsupercapacitor fabrication with specific capacitance values as high as 287 µF cm−2 and energy and power density approaching LIG-based supercapacitors fabricated onto traditional polyimide substrates
Detection of the Cherenkov light diffused by Sea Water with the ULTRA Experiment
The study of Ultra High Energy Cosmic Rays represents one of the most
challenging topic in the Cosmic Rays and in the Astroparticle Physics fields.
The interaction of primary particles with atmospheric nuclei produces a huge
Extensive Air Shower together with isotropic emission of UV fluorescence light
and highly directional Cherenkov photons, that are reflected/diffused
isotropically by the impact on the Earth's surface or on high optical depth
clouds. For space-based observations, detecting the reflected Cherenkov signal
in a delayed coincidence with the fluorescence light improves the accuracy of
the shower reconstruction in space and in particular the measurement of the
shower maximum, giving a strong signature for discriminating hadrons and
neutrinos, and helping to estimate the primary chemical composition. Since the
Earth's surface is mostly covered by water, the ULTRA (UV Light Transmission
and Reflection in the Atmosphere)experiment has been designed to provide the
diffusing properties of sea water, overcoming the lack of information in this
specific field. A small EAS array, made up of 5 particle detectors, and an UV
optical device, have been coupled to detect in coincidence both electromagnetic
and UV components. The detector was in operation from May to December, 2005, in
a small private harbor in Capo Granitola (Italy); the results of these
measurements in terms of diffusion coefficient and threshold energy are
presented here.Comment: 4 pages, 3 figures, PDF format, Proceedings of 30th ICRC,
International Cosmic Ray Conference 2007, Merida, Yucatan, Mexico, 3-11 July
200
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