Doctor of Philosophy

dissertationDNA double-strand break (DSB) repair gene products play an important role in development and tumor suppression. Mutations in ATM, BRCA1, BRCA2, MRE11, NBN, PALB2, RAD50, RAD51, and XRCC2 result in embryonic lethality or cause pediatric diseases including ataxia-telangiectasia, Fanconi anemia (FA), Nijmegen breakage syndrome (NBS), and other disorders. A DNA DSB can be repaired using two different pathways: nonhomologous end-joining (NHEJ) and homology-directed DSB repair (HDR). Some DSB repair proteins, including ATM, Mre11, RAD50, and Nibrin, function in both pathways. RAD51 and its paralogs only function in HDR. Mre11-Rad50-Nibrin (MRN) complex is a heterohexamer composed of dimers of each protein. The MRN complex is important for early detection of DNA DSBs and activates downstream effectors, most notably the protein kinase ATM. ATM phosphorylates other DNA repair proteins including H2AX. H2AX, phosphorylated histone H2AX, is an important DNA damage signaling factor that helps recruit BRCA1 to damaged DNA. XRCC2 helps promote RAD51 foci through interaction with other RAD51 paralogs RAD51B, RAD51C, and RAD51D to form the BCDX2 complex. FA and NBS-like disorder result from biallelic mutations in XRCC2 and RAD50, respectively. These genetically distinct disorders share many clinical similarities. Bone marrow failure is a key symptom of FA and has been observed in multiple NBS patients. The hematopoietic malignancy acute myeloid leukemia has been observed in patients suffering from FA and NBS. Hormone abnormalities and fertility issues present in both patient populations as do issues with growth and development. Null mutations in RAD50 and XRCC2 are embryonic lethal in humans and mice, so zebrafish was chosen as the model organism to study mutations in each of these genes. Null mutations in related genes (e.g., BRCA2) that result in embryonic lethality in humans and mice are tolerated in zebrafish. Frameshift mutations were generated in rad50 and xrcc2 using transcription activator-like effector nucleases in zebrafish. We recovered the first viable vertebrate model for biallelic null mutations in RAD50 and XRCC2. Study of these mutants might offer unique insights into human disease that have not been possible previously due to a lack of appropriate model systems

Beyond Aristotelianism: al-Farabi on revelation, humans and animals in his on the Perfect State

In modern times, Aristotelian influence on Islamicate philosophical writing is exaggerated. Al-Fārābī did more than just copy Aristotle, he was an original thinker, and he may have sourced aspects of his thought and writing style from the Qurʾān. Consideration of al-Fārābī’s biography, works and historical context demonstrates his disinclination to base his writings on those of Aristotle. Al-Fārābī’s thoughts in the key area of revelation in al-Madīna al-fāḍila demonstrate his departure from ancient Greek belief in this area, although his use of individual reasoning also shows clearly his occasional disagreement with Islamic doctrine. Differences and commonalities between animals and humans as written by al-Fārābī can be compared with Aristotle’s dissimilar thoughts on these matters, refuting the idea that al-Fārābī was simply an Aristotelian philosopher. Use of the religious term fiṭra in al-Madīna al-fāḍila is a microcosm of its writer’s propensity to include the terminology of revealed religion in this book

Teaching Agile Development with DevOps in a Software Engineering and Database Technologies Practicum

[EN] DevOps is a new concept for Software Engineering. Teaching DevOps can be challenging with the limited resources that are available at many universities. This paper exams how to teach of an Agile Development Methodology using a DevOps approach for the Regis University (RU) M.S. in Software Engineering and Database Technologies Practicum. With faculty support, heavy stakeholder involvement and RU Information Technology Services (Operations Support) mentoring, students were able to successfully follow the Agile Development methodology to create an application that was incoporated into the RU Web-site infrastructure.Mason, R.; Masters, W.; Stark, A. (2017). Teaching Agile Development with DevOps in a Software Engineering and Database Technologies Practicum. En Proceedings of the 3rd International Conference on Higher Education Advances. Editorial Universitat Politècnica de València. 1353-1362. https://doi.org/10.4995/HEAD17.2017.5607OCS1353136

The Stoneflies (Plecoptera) of Oklahoma

Distributional data and taxonomic keys art presented for thirty-four species of Plecoptera known to occur in Oklahoma. Ten species are new records for the state. Descriptions are provided for two species new to science, Zealeuctra cherokee and Isoperla brevis, and for the previously unknown male of Strophopteryx cucullata Frison and female of Helopicus nalatus (Frison)

The biosynthesis of sulphur-containing dioxopiperazines

Summary availabl

Genetic Structure and Systematics of Smallmouth Bass: Zoogeography and Implications for Conservation

Wildlife and Fisheries Ecolog

A study of the effect of span and number of bays on economy of framing material in single story gabled structures utilizing articulated wedge-beam framing.

http://www.archive.org/details/studyofeffectofs00spa